5-aMino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxaMide
- CAS No.
- 1082745-50-3
- Chemical Name:
- 5-aMino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxaMide
- Synonyms
- EOS-62038;5-Amino-1-(tetrahydro-2H-pyran-4-yl);5-amino-1-(4-oxanyl)-4-pyrazolecarboxamide;5-amino-1-(oxan-4-yl)pyrazole-4-carboxamide;5-Amino-1-(oxan-4-yl)-1H-pyrazole-4-carboxamide;5-aMino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxaMide;1H-Pyrazole-4-carboxamide, 5-amino-1-(tetrahydro-2H-pyran-4-yl)-;5-AMino-1-(tetrahydro-pyran-4-yl)-1H-pyrazole-4-carboxylic acid aMide
- CBNumber:
- CB22553595
- Molecular Formula:
- C9H14N4O2
- Molecular Weight:
- 210.23
- MDL Number:
- MFCD12405839
- MOL File:
- 1082745-50-3.mol
| Product description | Number | Pack Size | Price |
| 5-Amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide | A630998 | 500mg | $330 |
| 5-Amino-1-(oxan-4-yl)-1H-pyrazole-4-carboxamide | OR310332 | 500mg | $419 |
| 5-Amino-1-(oxan-4-yl)-1H-pyrazole-4-carboxamide | 4H48-1-MF | 500mg | $496 |
| 5-Amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide 95+% | 35445 | 100mg | $545 |
| 5-Amino-1-(oxan-4-yl)-1H-pyrazole-4-carboxamide | OR310332 | 1g | $568 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| HS Code | 2922390090 |
5-aMino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxaMide price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A630998 | 5-Amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide | 1082745-50-3 | 500mg | $330 | 2021-12-16 | Buy |
| Apolloscientific | OR310332 | 5-Amino-1-(oxan-4-yl)-1H-pyrazole-4-carboxamide | 1082745-50-3 | 500mg | $419 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H48-1-MF | 5-Amino-1-(oxan-4-yl)-1H-pyrazole-4-carboxamide | 1082745-50-3 | 500mg | $496 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 35445 | 5-Amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide 95+% | 1082745-50-3 | 100mg | $545 | 2021-12-16 | Buy |
| Apolloscientific | OR310332 | 5-Amino-1-(oxan-4-yl)-1H-pyrazole-4-carboxamide | 1082745-50-3 | 1g | $568 | 2021-12-16 | Buy |
5-aMino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxaMide Chemical Properties,Uses,Production
Uses
5-Amino-1-(tetrahydro-pyran-4-yl)-1H-pyrazole-4-carboxylic acid amide is an amide organic compound that can be used as a pharmaceutical intermediate.
Synthesis
1082745-49-0
1082745-50-3
General procedure for the synthesis of 5-amino-1-(tetrahydro-pyran-4-yl)-1H-pyrazole-4-carbonitrile as 5-amino-1-(tetrahydro-pyran-4-yl)-1H-pyrazole-4-carboxylic acid amide: 5-amino-1-(tetrahydro-pyran-4-yl)-1H-pyrazole-4-carbonitrile (<228 mmol, the crude product from the previous reaction) was dissolved in ethanol ( 300 mL) in a 35% aqueous hydrogen peroxide solution (100 mL) and concentrated ammonia (300 mL) were added sequentially. The reaction mixture was stirred at room temperature for 48 h. The reaction was subsequently quenched with saturated aqueous sodium thiosulfate solution (800 mL). Ethanol was removed by distillation under reduced pressure and the resulting solid was separated by filtration and washed with water (2 x 200 mL) and ether (2 x 150 mL) to afford 5-amino-1-(tetrahydro-pyran-4-yl)-1H-pyrazole-4-carboxylic acid amide (31 g, 147 mmol). The overall yield of the two-step reaction from the starting material to the target product was 64%.ESI-MS (M-H)-: 211 (calculated value C9H14N4O2: 210.1).
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 21, p. 9045 - 9054
[2] Patent: WO2014/131855, 2014, A1. Location in patent: Page/Page column 151
[3] Patent: WO2014/16789, 2014, A1. Location in patent: Page/Page column 21
[4] Patent: US2017/291901, 2017, A1. Location in patent: Paragraph 0168; 0169
[5] Patent: US2009/30003, 2009, A1. Location in patent: Page/Page column 36
5-aMino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxaMide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Nanjing Bicbiotechnology Co., Ltd | +86-2552131256 +86-18251840740 | sales@bicbiotech.com | China | 5994 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39002 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10186 | 62 |
