6-Chloro-4-methoxypyridine-3-carbonitrile
- CAS No.
- 1187190-69-7
- Chemical Name:
- 6-Chloro-4-methoxypyridine-3-carbonitrile
- Synonyms
- 6-chloro-4-Methoxynicotinonitrile;6-Chloro-4-methoxypyridine-3-carbonitrile;6-Chloro-4-methoxy-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 6-chloro-4-methoxy-;6-Chloro-4-Methoxy-Nicotinonitrile(WX683504);6-Chloro-4-Methoxy-Nicotinonitrile Achiral 73.43
- CBNumber:
- CB22556460
- Molecular Formula:
- C7H5ClN2O
- Molecular Weight:
- 168.58
- MDL Number:
- MFCD16250655
- MOL File:
- 1187190-69-7.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P280 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
6-Chloro-4-methoxypyridine-3-carbonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 066788 | 6-Chloro-4-methoxypyridine-3-carbonitrile | 1187190-69-7 | 1.00g | $54 | 2026-05-18 | Buy |
| Matrix Scientific | 066788 | 6-Chloro-4-methoxypyridine-3-carbonitrile | 1187190-69-7 | 5.00g | $219 | 2026-05-18 | Buy |
| Matrix Scientific | 066788 | 6-Chloro-4-methoxypyridine-3-carbonitrile | 1187190-69-7 | 10.00g | $419 | 2026-05-18 | Buy |
| Synthonix | C44835 | 6-Chloro-4-methoxynicotinonitrile 96% | 1187190-69-7 | 250mg | $52 | 2026-05-06 | Buy |
| Synthonix | C44835 | 6-Chloro-4-methoxynicotinonitrile 96% | 1187190-69-7 | 1g | $60 | 2026-05-06 | Buy |
6-Chloro-4-methoxypyridine-3-carbonitrile Chemical Properties, Uses, Production
Synthesis
166526-03-0
124-41-4
1187190-69-7
Synthesis of 6-chloro-4-methoxy-3-cyanopyridine (2): to a solution of 4,6-dichloronicotinonitrile (1) (200 mg, 1.06 mmol) in anhydrous methanol (10 mL) was added sodium methanol solution (0.5 M in MeOH, 2.12 mL, 1.06 mmol). The reaction mixture was stirred at 60 °C overnight. After completion of the reaction, the mixture was cooled to room temperature and neutralized by addition of hydrochloric acid (1 M, 8 mL). Subsequently, the volatile components were removed by distillation under reduced pressure. The product was purified by a Biotage fast chromatography system (elution gradient: 10%-50% ethyl acetate/hexane) to afford 6-chloro-4-methoxy-3-cyanopyridine (150 mg, 77% yield). The structure of the product was confirmed by 1H NMR (400 MHz, chloroform-d): δ 8.48 (s, 1H), 6.98 (s, 1H), 4.03 (s, 3H).
References
[1] Patent: US2015/291629, 2015, A1. Location in patent: Paragraph 1104
6-Chloro-4-methoxypyridine-3-carbonitrile Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Record Tech (Shanghai) Co., LTD | 13761627472 | 183009664@qq.com | China | 660 | 62 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. | +86-28-85122536 85324413 | market@astatech.cn | China | 8016 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 0512-0512-52358471 17715136450 | sales@shiyabiopharm.com | China | 9814 | 58 |
| Zhengzhou AiXi Technology Co., Ltd. | 0371-56787280 13137706083 | m18539565376@163.com | China | 999 | 55 |
