Methyl 2,3-dichloropropionate
- CAS No.
- 3674-09-7
- Chemical Name:
- Methyl 2,3-dichloropropionate
- Synonyms
- 2,3-dichloropropionate;METHYL-A,B-DICHLOROPROPIONATE;METHYL 2,3-DICHLOROPROPIONATE;Methyl 2,3-dichloropropanoate;Methyl2,3-Dichloropropionate>Methyl 2,3-dichloropropionate,98%;METHYL ALPHA,BETA-DICHLOROPROPIONATE;2,3-dichloro-propanoicacimethylester;2,3-Dichloropropionic Acid Methyl Este;2,3-DICHLOROPROPIONIC ACID METHYL ESTER
- CBNumber:
- CB2257329
- Molecular Formula:
- C4H6Cl2O2
- Molecular Weight:
- 157
- MDL Number:
- MFCD00000944
- MOL File:
- 3674-09-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 2,3-dichloropropionate for synthesis | 8.18319 | 10ml | $44.2 |
| Methyl 2,3-Dichloropropionate >95.0%(GC) | D0408 | 10g | $30 |
| Methyl 2,3-dichloropropanoate >98% | M69066 | 500g | $140 |
| Methyl 2,3-dichloropropionate 97% | MT-17744 | 1000g | $415 |
| Methyl 2,3-dichloropropionate 97% | MT-17744 | 1000g | $415 |
| More product size | |||
| Boiling point | 52-55 °C/2 mmHg (lit.) |
|---|---|
| Density | 1.325 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 145 °F |
| storage temp. | Store below +30°C. |
| solubility | Soluble in ether, acetone, ethanol. |
| form | liquid |
| color | Colorless to Almost colorless |
| BRN | 1701891 |
| InChI | InChI=1S/C4H6Cl2O2/c1-8-4(7)3(6)2-5/h3H,2H2,1H3 |
| InChIKey | OFHMODDLBXETIK-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C(Cl)CCl |
| CAS DataBase Reference | 3674-09-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Propanoic acid, 2,3-dichloro-, methyl ester(3674-09-7) |
| EPA Substance Registry System | Propanoic acid, 2,3-dichloro-, methyl ester (3674-09-7) |
| UNSPSC Code | 12352108 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) | ![]() ![]() GHS05,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H318-H227-H314-H341 | |||||||||
| Precautionary statements | P201-P202-P210-P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P308+P313-P403+P235-P405-P501-P210e-P260h-P303+P361+P353-P305+P351+P338-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-10 | |||||||||
| Safety Statements | 23-24/25-37/39-26-16 | |||||||||
| RIDADR | 1993 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29159000 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Methyl 2,3-dichloropropionate price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.18319 | Methyl 2,3-dichloropropionate for synthesis | 3674-09-7 | 10ml | $44.2 | 2024-03-01 | Buy |
| TCI Chemical | D0408 | Methyl 2,3-Dichloropropionate >95.0%(GC) | 3674-09-7 | 10g | $30 | 2026-04-30 | Buy |
| Synthonix | M69066 | Methyl 2,3-dichloropropanoate >98% | 3674-09-7 | 500g | $140 | 2026-05-06 | Buy |
| AHH | MT-17744 | Methyl 2,3-dichloropropionate 97% | 1000g | $415 | 2026-05-26 | Buy | |
| AHH | MT-17744 | Methyl 2,3-dichloropropionate 97% | 1000g | $415 | 2026-05-25 | Buy |
Methyl 2,3-dichloropropionate Chemical Properties,Uses,Production
Chemical Properties
clear colorless to slightly yellow liquid
Uses
Methyl 2,3-dichloropropionate can be used to produce 2-chloro-acrylic acid methyl ester at Heating. It is used as pharmaceutical intermediate.
Application
Methyl 2,3-Dichloropropanoate is a useful reagent in preparation of oxidative fragmentation and coupling of catharanthine analogs to vindoline.
Synthesis
Preparation of Methyl 2,3-dichloropropanoate:
Methyl acrylate (2366 g, 27.5 mol) and dimethylformamide (DMF) (40 g, 0.55 mol) was placed in a 3-liter three necked flask fitted with a stirrer, thermometer, inlet tube and gas trap. Chlorine (950 g, 0.48 mol) was passed into the methyl acrylate rapidly over a period of ten hours while the temperature was kept below 40°C. Reaction progress was monitored by gas chromatography (GC). When it seemed that 50 percent of chlorine was consumed, the reaction was stopped. The reaction mass was taken for distillation to separate methylacrylate and Methyl 2,3-dichloropropanoate. The contents were subjected to vacuum distillation. Methyl 2,3-dichloropropanoate was collected distilling at 70°C with 15mm.Yield (%):77.2, Purity (%) = 98.
Methyl 2,3-dichloropropionate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 4000 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21588 | 55 |
| AB PharmaTech,LLC | 323-480-4688 | sales@acrospharmatech.com | United States | 989 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
View Lastest Price from Methyl 2,3-dichloropropionate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-03-31 | Methyl 2,3-dichloropropionate
3674-09-7
|
US $100.00 / g | 1000g | 98% | 10tons | Puyang Huicheng Electronic Materials Co., Ltd. | |
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2026-03-20 | Methyl 2,3-dichloropropionate
3674-09-7
|
US $0.00-0.00 / KG | 1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
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2025-09-25 | Methyl 2,3-dichloropropanoate
3674-09-7
|
US $200.00-1.00 / KG | 1KG | 99%, 99.5% Sublimated | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-

- Methyl 2,3-dichloropropionate
3674-09-7
- US $100.00 / g
- 98%
- Puyang Huicheng Electronic Materials Co., Ltd.
-

- Methyl 2,3-dichloropropionate
3674-09-7
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-

- Methyl 2,3-dichloropropanoate
3674-09-7
- US $200.00-1.00 / KG
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
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