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Methyl 2,3-dichloropropionate

Methyl 2,3-dichloropropionate Structure
Methyl 2,3-dichloropropionate structure
CAS No.
3674-09-7
Chemical Name:
Methyl 2,3-dichloropropionate
Synonyms
2,3-dichloropropionate;Methyl 2,3-dichloropropanoate;METHYL-A,B-DICHLOROPROPIONATE;METHYL 2,3-DICHLOROPROPIONATE;Methyl2,3-Dichloropropionate>Methyl 2,3-dichloropropionate,98%;METHYL ALPHA,BETA-DICHLOROPROPIONATE;2,3-dichloro-propanoicacimethylester;2,3-Dichloropropionic Acid Methyl Este;2,3-DICHLOROPROPIONIC ACID METHYL ESTER
CBNumber:
CB2257329
Molecular Formula:
C4H6Cl2O2
Molecular Weight:
157
MDL Number:
MFCD00000944
MOL File:
3674-09-7.mol
MSDS File:
SDS
Last updated:2026-05-28 00:01:53
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Methyl 2,3-dichloropropionate Properties

Boiling point 52-55 °C/2 mmHg (lit.)
Density 1.325 g/mL at 25 °C (lit.)
refractive index n20/D 1.453(lit.)
Flash point 145 °F
storage temp. Store below +30°C.
solubility Soluble in ether, acetone, ethanol.
form liquid
color Colorless to Almost colorless
BRN 1701891
InChI InChI=1S/C4H6Cl2O2/c1-8-4(7)3(6)2-5/h3H,2H2,1H3
InChIKey OFHMODDLBXETIK-UHFFFAOYSA-N
SMILES C(OC)(=O)C(Cl)CCl
CAS DataBase Reference 3674-09-7(CAS DataBase Reference)
NIST Chemistry Reference Propanoic acid, 2,3-dichloro-, methyl ester(3674-09-7)
EPA Substance Registry System Propanoic acid, 2,3-dichloro-, methyl ester (3674-09-7)
UNSPSC Code 12352108

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Health Hazard (GHS08)
GHS05,GHS08
Signal word  Danger
Hazard statements  H318-H227-H314-H341
Precautionary statements  P201-P202-P210-P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P308+P313-P403+P235-P405-P501-P210e-P260h-P303+P361+P353-P305+P351+P338-P501a
Hazard Codes  Xi
Risk Statements  36/37/38-10
Safety Statements  23-24/25-37/39-26-16
RIDADR  1993
WGK Germany  3
TSCA  TSCA listed
HazardClass  8
PackingGroup  III
HS Code  29159000
Storage Class 10 - Combustible liquids
REACH Registrations Active
NFPA 704
2
3 0

Methyl 2,3-dichloropropionate price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.18319 Methyl 2,3-dichloropropionate for synthesis 3674-09-7 10ml $44.2 2024-03-01 Buy
TCI Chemical D0408 Methyl 2,3-Dichloropropionate >95.0%(GC) 3674-09-7 10g $30 2026-04-30 Buy
Apolloscientific OR937030 Methyl 2,3-dichloropropionate >98% 3674-09-7 100g $32 2026-06-04 Buy
Apolloscientific OR937030 Methyl 2,3-dichloropropionate >98% 3674-09-7 500g $88 2026-06-04 Buy
Apolloscientific OR937030 Methyl 2,3-dichloropropionate >98% 3674-09-7 2.5kg $364 2026-06-04 Buy
Product number Packaging Price Buy
8.18319 10ml $44.2 Buy
D0408 10g $30 Buy
OR937030 100g $32 Buy
OR937030 500g $88 Buy
OR937030 2.5kg $364 Buy

Methyl 2,3-dichloropropionate Chemical Properties,Uses,Production

Chemical Properties

clear colorless to slightly yellow liquid

Uses

Methyl 2,3-dichloropropionate can be used to produce 2-chloro-acrylic acid methyl ester at Heating. It is used as pharmaceutical intermediate.

Application

Methyl 2,3-Dichloropropanoate is a useful reagent in preparation of oxidative fragmentation and coupling of catharanthine analogs to vindoline.

Synthesis

Preparation of Methyl 2,3-dichloropropanoate:
Methyl acrylate (2366 g, 27.5 mol) and dimethylformamide (DMF) (40 g, 0.55 mol) was placed in a 3-liter three necked flask fitted with a stirrer, thermometer, inlet tube and gas trap. Chlorine (950 g, 0.48 mol) was passed into the methyl acrylate rapidly over a period of ten hours while the temperature was kept below 40°C. Reaction progress was monitored by gas chromatography (GC). When it seemed that 50 percent of chlorine was consumed, the reaction was stopped. The reaction mass was taken for distillation to separate methylacrylate and Methyl 2,3-dichloropropanoate. The contents were subjected to vacuum distillation. Methyl 2,3-dichloropropanoate was collected distilling at 70°C with 15mm.Yield (%):77.2, Purity (%) = 98.

Methyl 2,3-dichloropropionate Preparation Products And Raw materials

Raw materials

Preparation Products

Methyl 2,3-dichloropropionate Suppliers

Global( 185)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan kemike Biomedical Technology Co., Ltd 027-87747081 18186681184 1344475572@qq.com China 6978 58
Nanjing Winsome Chemical Limited 025-84651981 18652010011 sales@nastchem.com China 81 58
HANGZHOU LOOP BIOTECH CO., LTD. 057185260761 13396556070 sales@looppharm.com China 56 58
Shanghai Birch Chemical Technology Co., Ltd. 021-54096810 18017263450 sales@birchchem.com China 500 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
Wuhan kemike Biomedical Technology Co., Ltd 58
Nanjing Winsome Chemical Limited 58
HANGZHOU LOOP BIOTECH CO., LTD. 58
Shanghai Birch Chemical Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61

View Lastest Price from Methyl 2,3-dichloropropionate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methyl 2,3-dichloropropanoate pictures 2026-09-02 Methyl 2,3-dichloropropanoate
3674-09-7
 $1.00-200.00 1KG 99%, 99.5% Sublimated Henan Fengda Chemical Co., Ltd
Methyl 2,3-dichloropropionate pictures 2026-03-31 Methyl 2,3-dichloropropionate
3674-09-7
 $100.00 1000g 98% 10tons Puyang Huicheng Electronic Materials Co., Ltd.
Methyl 2,3-dichloropropionate pictures 2026-03-20 Methyl 2,3-dichloropropionate
3674-09-7
 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd

Methyl 2,3-dichloropropionate Spectrum

Methyl 2,3-dichloropropionate(3674-09-7)MSMethyl 2,3-dichloropropionate(3674-09-7)1HNMRMethyl 2,3-dichloropropionate(3674-09-7)13CNMRMethyl 2,3-dichloropropionate(3674-09-7)IR1Methyl 2,3-dichloropropionate(3674-09-7)IR2

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METHYL 2,3-DICHLOROPROPIONATE METHYL-A,B-DICHLOROPROPIONATE METHYL ALPHA,BETA-DICHLOROPROPIONATE 2,3-DICHLOROPROPIONIC ACID METHYL ESTER 2,3-dichloro-propanoicacimethylester Propionic acid, 2,3-dichloro-, methyl ester METHYL-2,3-DICHLOROPROPIONATE, 1000MG, N EAT Methyl 2,3-dichloropropionate, tech., 70% Propanoic acid, 2,3-dichloro-, methyl ester 2,3-dichloro-propanoic acid methyl ester Methyl 2,3-dichloropropionate,98% Methyl 2,3-dichloropropionate,70%,tech. Methyl 2,3-dichloropropionate, tech., 70% 25ML METHYL 2,3-DICHLOROPROPIONATE FOR SYNTHE Methyl2,3-Dichloropropionate> Propanoic acid, 2,3-dichloro-, methyl ester (9CI, ACI) 2,3-dichloro-Propanoic acid methyl ester (9CI ACI) 2,3-Dichloropropionic Acid Methyl Este 2,3-dichloropropionate Methyl 2,3-dichloropropanoate 3674-09-7 648-19-2 674-09-7 3674-09-07 ClCH2CHClCOOCH3 Alpha Sort M MAlphabetic META - METH Volatiles/ Semivolatiles