2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester
- CAS No.
- 36745-93-4
- Chemical Name:
- 2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester
- Synonyms
- Methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate;(3-BROMOPHENYL)(3-PYRIDINYL)METHANONE;(S)-methyl 2-(morpholin-3-yl)acetate HCL;methyl2,4-dichloro-6-methylpyrimidine-5-carboxyla;Methyl 2,4-dichloro-6-methyl-5-pyrimidinecarboxylate;2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester;5-Pyrimidinecarboxylic acid, 2,4-dichloro-6-methyl-, methyl ester;2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester ISO 9001：2015 REACH;methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylatemethyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate
- CBNumber:
- CB22574699
- Molecular Formula:
- C7H6Cl2N2O2
- Molecular Weight:
- 221.04
- MDL Number:
- MFCD22572319
- MOL File:
- 36745-93-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate | 200660 | 1.00g | $397 |
| Methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate 95+% | M38844 | 250mg | $29 |
| Methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate 95+% | M38844 | 1g | $30 |
| Methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate 95+% | M38844 | 5g | $130 |
| Methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate 95+% | M38844 | 10g | $250 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 200660 | Methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate | 36745-93-4 | 1.00g | $397 | 2026-05-18 | Buy |
| Synthonix | M38844 | Methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate 95+% | 36745-93-4 | 250mg | $29 | 2026-05-06 | Buy |
| Synthonix | M38844 | Methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate 95+% | 36745-93-4 | 1g | $30 | 2026-05-06 | Buy |
| Synthonix | M38844 | Methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate 95+% | 36745-93-4 | 5g | $130 | 2026-05-06 | Buy |
| Synthonix | M38844 | Methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate 95+% | 36745-93-4 | 10g | $250 | 2026-05-06 | Buy |
2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester Chemical Properties,Uses,Production
Uses
2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic Acid Methyl Ester is used in preparation of 4,6,7-Trisubstituted 1,2-dihydropyrrol[3,4-c]pyridin/pyrimidin-3 -one derivatives useful as Btk kinase inhibitors.
Synthesis
869891-41-8
36745-93-4
General procedure for the synthesis of methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate from methyl 2,4-dihydroxy-6-methylpyridine-5-carboxylate: 6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid methyl ester (1 g, 5.43 mmol) was suspended in POCl3 (10 mL) and N,N-dimethylaniline (10 drops ). The reaction mixture was heated at 105 °C for 6 h until a clarified solution was formed. Upon completion of the reaction, the mixture was cooled to room temperature, concentrated under reduced pressure and subsequently poured into ice water and extracted with ethyl acetate (EtOAc). The organic phases were combined, washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate (940 mg, 78% yield) as a yellow-green solid. Mass spectrometry analysis: [M + H]+ C7H6Cl2N2O2 calculated value was 222, measured values were 221 and 223.
References
[1] Patent: US2011/152273, 2011, A1. Location in patent: Page/Page column 28
[2] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 24, p. 5947 - 5950
[3] Patent: WO2015/131080, 2015, A1. Location in patent: Paragraph 00270; 00274
[4] Patent: US2014/148454, 2014, A1. Location in patent: Paragraph 0676
[5] Patent: WO2014/82739, 2014, A1. Location in patent: Page/Page column 59
2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester Preparation Products And Raw materials
2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21189 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29096 | 58 |
| Labnetwork lnc. | +86-27-50766799 +86-18062016861 | contact@labnetwork.com | China | 19981 | 58 |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +86-15195660023 | 3899766280@qq.com | China | 26349 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43303 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57473 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52906 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +86-18168183658 | sales1@artkmedchem.com | China | 39007 | 58 |
View Lastest Price from 2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester
36745-93-4
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
-
- 2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester
36745-93-4
- $1.10
- 99.00%
- Dideu Industries Group Limited
