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Ertugliflozin

Ertugliflozin structure

CAS No.: 1210344-57-2

Chemical Name:: Ertugliflozin

Synonyms: Ertugliflozin;(1S,2S,3S,4R,5S)-(2,3,4-TRIS-BENZYLOXY-5-(4-CHLORO-3-(4-ETHOXY-BENZYL)-PHENYL)-68-DIOXA-BICYCLO(3.2.1)OCT-1-YL)-METHANOL;(1S,2S,3S,4R,5S)-5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol;(1S,2S,3S,4R,5S)-5-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol;1,6-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-(hydroxymethyl)-beta-L-idopyranose PF-04971729(Ertugliflozin);CS-186;MK-8835;PF-04971729;Epagliflozin;PF 04971729-00

CBNumber:: CB22583105

Molecular Formula:: C22H25ClO7

Molecular Weight:: 436.88

MDL Number:: MFCD21609259

MOL File:: 1210344-57-2.mol

MSDS File:: SDS

Last updated:2025-04-17 18:22:24

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Ertugliflozin Properties

Melting point	65 - 66oC
Boiling point	630.5±55.0 °C(Predicted)
Density	1.455
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	12.95±0.70(Predicted)
form	Solid
color	White to Off-White
InChIKey	MCIACXAZCBVDEE-RDZQEHASNA-N
SMILES	[C@@]12(C3C=CC(Cl)=C(CC4C=CC(OCC)=CC=4)C=3)OC[C@@](CO)([C@@H](O)[C@H](O)[C@H]1O)O2 \|&1:0,20,23,25,27,r\|
FDA UNII	6C282481IP
ATC code	A10BK04

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H318-H314

Precautionary statements

P280-P305+P351+P338-P310-P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501

NFPA 704

	0
3		0

Ertugliflozin price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21507	Ertugliflozin ≥98%	1210344-57-2	1mg	$37	2024-03-01	Buy
Cayman Chemical	21507	Ertugliflozin ≥98%	1210344-57-2	5mg	$161	2024-03-01	Buy
Cayman Chemical	21507	Ertugliflozin ≥98%	1210344-57-2	10mg	$283	2024-03-01	Buy
Cayman Chemical	21507	Ertugliflozin ≥98%	1210344-57-2	25mg	$618	2024-03-01	Buy
American Custom Chemicals Corporation	INB0001388	(1R,2S,3S,4R,5R)-5-(4-CHLORO-3-(4-ETHOXYBENZYL)PHENYL)-1-(HYDROXYMETHYL)-6,8-DIOXABICYCLO[3.2.1]OCTANE-2,3,4-TRIOL 95.00%	1210344-57-2	0.025G	$671	2021-12-16	Buy

Product number	Packaging	Price	Buy
21507	1mg	$37	Buy
21507	5mg	$161	Buy
21507	10mg	$283	Buy
21507	25mg	$618	Buy
INB0001388	0.025G	$671	Buy

Ertugliflozin Chemical Properties,Uses,Production

Uses

Ertugliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor used to treat type 2 diabetes.

Definition

ChEBI: Ertugliflozin is a diarylmethane.

Application

Ertugliflozin is a medication prescribed by veterinarians to help control insulin (blood sugar) levels in horses and ponies with insulin dysregulation (ID), equine metabolic syndrome (EMS), refractory hyperinsulinemia (high blood sugar), and hyperinsulinemic-associated laminitis (HAL), especially for horses that don't respond to changes in diet or other accepted management practices for metabolic syndromes. Ertugliflozin is not FDA-approved for equine use. It falls into the sodium-glucose co-transport-2 (SGLT2) inhibitors category and is administered orally at 0.05?mg/kg once daily for at least 30?days.

in vivo

Ertugliflozin (PF-04971729) reveals a concentration-dependent glucosuria after oral administration to rats^[3].

IC 50

SGLT2

Mode of action

Ertugliflozin works by inhibiting the SGLT2 protein, which aids in the reabsorption of glucose in the kidneys, leading to excretion of more glucose through urine. Once daily doses of ertugliflozin have been shown to: Lower blood sugar levels, Correct insulin to normal or near-normal levels, and Reduce abnormal fat pads.

Ertugliflozin Preparation Products And Raw materials

Raw materials

Preparation Products

Ertugliflozin Suppliers

Global( 217)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Protheragen-ING	+16313385890	info@protheragen-ing.com	United States	3868	58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	+86-18600796368 +86-18600796368	sales@sjar-tech.com	China	485	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21628	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	340	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Shanghai Longyu Biotechnology Co., Ltd.	+8619521488211	info@longyupharma.com	China	2556	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49732	58

Supplier	Advantage
Protheragen-ING	58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	58
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Anqing Chico Pharmaceutical Co., Ltd.	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Shanghai Longyu Biotechnology Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from Ertugliflozin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-03-26	PF-04971729 1210344-57-2	US $412.00 / g/Bag	1g	99%	1kg	Baoji Guokang Bio-Technology Co., Ltd.
2025-01-13	Ertugliflozin 1210344-57-2	US $0.00 / g	1g	More Than 99%	100kg/Month	BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
2024-11-26	Ertugliflozin 1210344-57-2	US $0.00-0.00 / kg	1kg	99%, Single impurity＜0.1	1 ton	Nanjing Fred Technology Co., Ltd

PF-04971729
1210344-57-2
US $412.00 / g/Bag
99%
Baoji Guokang Bio-Technology Co., Ltd.

Ertugliflozin
1210344-57-2
US $0.00 / g
More Than 99%
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Ertugliflozin
1210344-57-2
US $0.00-0.00 / kg
99%, Single impurity＜0.1
Nanjing Fred Technology Co., Ltd

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PF-04971729/PF04971729 1,6-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-(hydroxymethyl)-beta-L-idopyranose Ertugliflozin, >=98% Ertugliflozin : PF 04971729-00 Leuco methylthioninium (1S,2S,3S,4R,5S)-5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol Ertugliflozin Base (1S,2S,3S,4R,5S)-(2,3,4-TRIS-BENZYLOXY-5-(4-CHLORO-3-(4-ETHOXY-BENZYL)-PHENYL)-68-DIOXA-BICYCLO(3.2.1)OCT-1-YL)-METHANOL PF 04971729-00 PF-04971729/Ertugliflozin 1,6-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-(hydroxymethyl)-beta-L-idopyranose PF-04971729(Ertugliflozin) Ertugliflozin MK-8835 PF-04971729 Ertugliflozin Ertugliflozin/PF-04971729 (1S,2S,3S,4R,5S)-5-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol β-L-Idopyranose, 1,6-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-(hydroxymethyl)- CS-186 PF04971729;PF 04971729 (ERTUGLIFLOZIN) ERTUGLIFLOZIN;PF04971729;PF 04971729 MK-8835 1,6-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-(hydroxymethyl)-β-L-idopyranose PF-04971729 USP/EP/BP Ertugliflozin D4 MK-8835， PF-04971729 Empagliflozin Impurity 225 Ertugliflozin Intermediate PF05 Leuco methylthioninium Impurity Epagliflozin Ertugliflozin, 10 mM in DMSO 1210344-57-2 C22H25ClO7 C22H25CIO7 API