4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine
- CAS No.
- 1357476-67-5
- Chemical Name:
- 4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine
- Synonyms
- 100346;4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl);4-Bromo-2-(2,2,2-trifluoro-1,1-dimethylethyl)pyridine;4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine;Pyridine, 4-bromo-2-(2,2,2-trifluoro-1,1-dimethylethyl)-
- CBNumber:
- CB22598749
- Molecular Formula:
- C9H9BrF3N
- Molecular Weight:
- 268.07
- MDL Number:
- MFCD22393679
- MOL File:
- 1357476-67-5.mol
- MSDS File:
- SDS
| Boiling point | 209.3±40.0 °C(Predicted) |
|---|---|
| Density | 1.473±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 2.29±0.10(Predicted) |
| Appearance | Colorless to light yellow Liquid |
| InChI | InChI=1S/C9H9BrF3N/c1-8(2,9(11,12)13)7-5-6(10)3-4-14-7/h3-5H,1-2H3 |
| InChIKey | XAQNICQGPIHIIH-UHFFFAOYSA-N |
| SMILES | C1(C(C)(C)C(F)(F)F)=NC=CC(Br)=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS154394 | 4-bromo-2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)pyridine 95% | 1357476-67-5 | 100mg | $238 | 2026-06-04 | Buy |
| Activate Scientific | AS154394 | 4-bromo-2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)pyridine 95% | 1357476-67-5 | 250mg | $370 | 2026-06-04 | Buy |
| Activate Scientific | AS154394 | 4-bromo-2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)pyridine 95% | 1357476-67-5 | 1g | $852 | 2026-06-04 | Buy |
| Matrix Scientific | 120592 | 4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine | 1357476-67-5 | 100.00mg | $163 | 2026-05-18 | Buy |
| Matrix Scientific | 120592 | 4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine | 1357476-67-5 | 250.00mg | $274 | 2026-05-18 | Buy |
4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine Chemical Properties, Uses, Production
Description
4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine is an important intermediate of Alpelisib, an oral kinase inhibitor used for the treatment of breast cancer.
Synthesis
To a solution of 18-6 (8.7 g, 42.40 mmol, 1 eq) in 1,2-dichloroethane (90 mL) was added Phosphorus(V) oxybromide (18.23 g, 63.60 mmol, 6.47 mL, 1.5 eq). The mixture was stirred at 80°C for 4 hours. TLC (Petroleum ether: Ethyl acetate: Ethanol =4:3:1) showed a part of starting material was remained. Another Phosphorus (V) oxybromide (6.08 g, 21.20 mmol, 2.16 mL, 0.5 eq) was added into the mixture. The reaction mixture was stirred at 80°C for another 3 hours. TLC (Petroleum ether: ethyl acetate: ethanol=4:3:1) showed the starting material was consumed completely. The mixture was combined with another batch (1 g scale) and then poured into ice saturated sodium bicarbonate solution (300 mL) and adjust the pH=7~8. The mixture was extracted with ethyl acetate (100 mLx3). The combined organic layers were washed with brine (100 mL), dried over anhydrous sodium sulfate, filtered, concentrated in vacuum. The residue was purified by column chromatography (SiO2, Petroleum ether: ethyl acetate=1:0 to 50:11) to give 18-7 (8.5 g, 31.71 mmol, 67.37% yield, 100% purity) as light yellow oil.
Synthesis
4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai ruichang pharmaceutical technology co., LTD | 18621054990 | maychemicals@sina.com | China | 673 | 58 |
| Suzhou Zehou Biotechnology Co. , Ltd. | 0512-68716880 19984816880 | sales@growingchem.com | China | 229 | 64 |
| CEG Chemical Science&Technology Co., Ltd. | Mobile:13665161512 | China | 1784 | 58 | |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 3014 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai AQBioPharma Co., Ltd. | 13661411401 | yinglv.que@aqbiopharma.com.cn | China | 2976 | 58 |
| Lanzhou Angeli Biochemical Technology Co., Ltd. | 0931-8235634 13321316780 | 1455540579@qq.com | China | 957 | 55 |
| Wuxi KaideRui Pharmaceutical Technology Co., Ltd | 19906241957 | 1557216087@qq.com | China | 1853 | 55 |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 6746 | 58 |
| Aikon International Limited | 025-58859352 15955137747 | sales01@aikonchem.com | China | 16021 | 58 |
View Latest Price from 4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine
1357476-67-5
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine
1357476-67-5
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
