ChemicalBook >> CAS DataBase List >>(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide

(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide

(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide structure

CAS No.: 432531-71-0

Chemical Name:: (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide

Synonyms: Necrosulfonami;Necrosulfonamide(b);Necrosulfonamide HCl;(E/Z)-Necrosulfonamide;(E/Z)-Necrosulfonamide, 10 mM in DMSO;Necrosulfonamide, necroptosis inhibitor;MLKL Inhibitor, Necrosulfonamide - CAS 432531-71-0 - Calbiochem;N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide;N-[4-[[(3-Methoxypyrazinyl)aMino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenaMide;(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide

CBNumber:: CB22620998

Molecular Formula:: C18H15N5O6S2

Molecular Weight:: 461.47

MDL Number:

MOL File:: 432531-71-0.mol

MSDS File:: SDS

Last updated:2025-01-27 09:38:02

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(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide Properties

storage temp.	+2C to +8C
solubility	DMSO:100.0(Max Conc. mg/mL);216.7(Max Conc. mM)
form	Dark yellow solid
color	Light yellow to yellow
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338

(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide price More Price(10)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	480073	MLKL Inhibitor, Necrosulfonamide - CAS 432531-71-0 - Calbiochem MLKL Inhibitor, Necrosulfonamide, CAS 432531-71-0, is a cell-permeable inhibitor that covalently modifies Cys88 and blocks human MLKL adaptor function.	432531-71-0	25mg	$245	2024-03-01	Buy
TRC	N388600	Necrosulfonamide	432531-71-0	1mg	$140	2021-12-16	Buy
TRC	N388600	Necrosulfonamide	432531-71-0	100mg	$1390	2021-12-16	Buy
Medical Isotopes, Inc.	60598	Necrosulfonamide	432531-71-0	1mg	$620	2021-12-16	Buy
Medical Isotopes, Inc.	60598	Necrosulfonamide	432531-71-0	10mg	$750	2021-12-16	Buy

Product number	Packaging	Price	Buy
480073	25mg	$245	Buy
N388600	1mg	$140	Buy
N388600	100mg	$1390	Buy
60598	1mg	$620	Buy
60598	10mg	$750	Buy

(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide Chemical Properties,Uses,Production

Chemical Properties

Yellow Solid

Uses

Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway.

Definition

ChEBI: Necrosulfonamide is a sulfonamide that is a 3-methoxypyrazin-2-yl derivative of (E)-N-(4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide. Necrosulfonamide specifically blocks necrosis downstream of the activation of RIP3 (the receptor-interacting serine-threonine kinase 3), a key signalling molecule in the programmed necrosis (necroptosis) pathway. It is a sulfonamide, a member of pyrazines and a member of thiophenes.

Biological Activity

Cell permeable: yes', 'Primary Target
human MLKL', 'Reversible: no

(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide Preparation Products And Raw materials

Raw materials

Preparation Products

(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide Suppliers

Global( 47)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32268	58
Finetech Industry Limited	+86-27-8746-5837 +8619945049750	info@finetechnology-ind.com	China	9642	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38663	58
Aladdin Scientific		tp@aladdinsci.com	United States	52924	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5221	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jk.info@jkchemical.com	China	96815	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32321	50
Bide Pharmatech Ltd.	400-164-7117 13681763483	product02@bidepharm.com	China	41457	60

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Finetech Industry Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Chemsky（shanghai）International Co.,Ltd.	50
Bide Pharmatech Ltd.	60

View Lastest Price from (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-05-02	(E/Z)-Necrosulfonamide 432531-71-0	US $33.00-71.00 / mg		97.62%	10g	TargetMol Chemicals Inc.

(E/Z)-Necrosulfonamide
432531-71-0
US $33.00-71.00 / mg
97.62%
TargetMol Chemicals Inc.

432531-71-0((E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide)Related Search:

Neomycin sulfate p-Anisidine 5-METHYL-N,N-DIMETHYLTRYPTAMINE

(E)-N-[4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophen-2-yl)prop-2-enamide MLKL Inhibitor, Necrosulfonamide - CAS 432531-71-0 - Calbiochem (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide Necrosulfonami N-[4-[[(3-Methoxypyrazinyl)aMino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenaMide Necrosulfonamide(b) 2-Propenamide, N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)- (E/Z)-Necrosulfonamide N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide Necrosulfonamide HCl Necrosulfonamide, necroptosis inhibitor (E/Z)-Necrosulfonamide, 10 mM in DMSO 432531-71-0