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ChemicalBook >> CAS DataBase List >>GSK-256066 (2,2,2-trifluoroacetic acid)

GSK-256066 (2,2,2-trifluoroacetic acid)

GSK-256066 (2,2,2-trifluoroacetic acid) Structure
GSK-256066 (2,2,2-trifluoroacetic acid) structure
CAS No.
1415560-64-3
Chemical Name:
GSK-256066 (2,2,2-trifluoroacetic acid)
Synonyms
GSK256066 (2;GSK-256066; GSK 256066;2-trifluoroacetic acid);GSK256066 trifluoroacetate;GSK-256066 (2,2,2-trifluoroacetic acid);GSK256066 Trifluoroacetate,GSK-256066 Trifluoroacetate;6-[[3-[(Dimethylamino)carbonyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methyl-3-quinolinecarboxamide 2,2,2-trifluoroacetate (1:1)
CBNumber:
CB22624178
Molecular Formula:
C29H27F3N4O7S
Molecular Weight:
632.61
MDL Number:
MFCD22125307
MOL File:
1415560-64-3.mol
Last updated:2025-07-23 21:37:54
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GSK-256066 (2,2,2-trifluoroacetic acid) Properties

storage temp. Store at -20°C
solubility DMSO : 50 mg/mL (79.04 mM; Need ultrasonic)
form Powder
color Light yellow to yellow

GSK-256066 (2,2,2-trifluoroacetic acid) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-1182 GSK256066(Trifluoroacetate) 99.54% 1415560-64-3 10mg $300 2021-12-16 Buy
ChemScene CS-1182 GSK256066(Trifluoroacetate) 99.54% 1415560-64-3 50mg $864 2021-12-16 Buy
Chemenu CM144217 6-((3-(dimethylcarbamoyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide2,2,2-trifluoroacetate 98% 1415560-64-3 50mg $439 2021-12-16 Buy
Crysdot CD31003576 GSK2560662,2,2-trifluoroaceticacid 98+% 1415560-64-3 50mg $469 2021-12-16 Buy
Crysdot CD31003576 GSK2560662,2,2-trifluoroaceticacid 98+% 1415560-64-3 5mg $91 2021-12-16 Buy
Product number Packaging Price Buy
CS-1182 10mg $300 Buy
CS-1182 50mg $864 Buy
CM144217 50mg $439 Buy
CD31003576 50mg $469 Buy
CD31003576 5mg $91 Buy

GSK-256066 (2,2,2-trifluoroacetic acid) Chemical Properties,Uses,Production

Uses

GSK256066 Trifluoroacetate is a selective and high-affinity phosphodiesterase 4 (PDE) inhibitor, with an IC50 of 3.2 pM for PDE4B. GSK256066 Trifluoroacetate is developed for the research of chronic obstructive pulmonary disease[1].

in vivo

GSK256066 Trifluoroacetate (0.3-100 μg/kg; intratracheally) inhibits the eosinophil number increased in the bronchoalveolar lavage (BAL) in a dose-dependent fashion, in lipopolysaccharide (LPS)- and ovalbumin (OVA)-induced acute pulmonary inflammation rat models.[2].
GSK256066 Trifluoroacetate inhibits LPS-induced pulmonary neutrophilia, and no emetic episodes are observed in ferrets[2].

Animal Model:Male Brown Norway rats(180-200 g)[2]
Dosage:0.3-100 μg/kg
Administration:Intratracheally; 30 minutes before and 6 hours after ovalbumin challenge
Result:Inhibited the increase in eosinophil number in the BAL in a dose-dependent fashion.

References

[1] Tralau-Stewart CJ, et al. GSK256066, an exceptionally high-affinity and selective inhibitor of phosphodiesterase 4 suitable for administration by inhalation: in vitro, kinetic, and in vivo characterization. J Pharmacol Exp Ther, 2011, 337(1), 145-154. DOI:10.1124/jpet.110.173690
[2] Nials AT, et al. In vivo characterization of GSK256066, a high-affinity inhaled phosphodiesterase 4 inhibitor. J Pharmacol Exp Ther, 2011, 337(1), 137-144. DOI:10.1124/jpet.110.173641

GSK-256066 (2,2,2-trifluoroacetic acid) Preparation Products And Raw materials

Raw materials

Preparation Products

GSK-256066 (2,2,2-trifluoroacetic acid) Suppliers

Global( 34)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32432 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39031 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19961 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7552 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4861 58
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2782 58
AdooQ Bioscience CHINA 025-58849295 18951903616; info@adooq.cn China 2990 60
Supplier Advantage
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
TargetMol Chemicals Inc. 		58
Amadis Chemical Company Limited 		58
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
AdooQ BioScience, LLC 58
AdooQ Bioscience CHINA 60

View Lastest Price from GSK-256066 (2,2,2-trifluoroacetic acid) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GSK256066 Trifluoroacetate pictures 2025-07-23 GSK256066 Trifluoroacetate
1415560-64-3
 US $78.00-995.00 / mg 10g TargetMol Chemicals Inc.
GSK256066 Trifluoroacetate pictures 2025-07-16 GSK256066 Trifluoroacetate
1415560-64-3
 US $78.00-995.00 / mg 10g TargetMol Chemicals Inc.
GSK-256066 (2,2,2-trifluoroacetic acid) 6-[[3-[(Dimethylamino)carbonyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methyl-3-quinolinecarboxamide 2,2,2-trifluoroacetate (1:1) GSK256066 trifluoroacetate GSK-256066; GSK 256066 2-trifluoroacetic acid) GSK256066 (2 GSK256066 Trifluoroacetate,GSK-256066 Trifluoroacetate 1415560-64-3 C27H26N4O5SC2HF3O2