QRX 431
- CAS No.
- 211110-63-3
- Chemical Name:
- QRX 431
- Synonyms
- SobetiroMe;GC-1;OLM4;EIEE3;NET44;PRO698;UNQ362;QRX 431;Anti-GC1;Anti-OlfD
- CBNumber:
- CB22628338
- Molecular Formula:
- C20H24O4
- Molecular Weight:
- 328.4
- MDL Number:
- MFCD19443713
- MOL File:
- 211110-63-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Sobetirome ≥98% (HPLC) | SML1900 | 5mg | $121 |
| Sobetirome ≥98% (HPLC) | SML1900 | 25mg | $491 |
| Anti-SLC25A22 antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution | HPA014662 | 100 μL | $667 |
| Anti-SLC25A22 antibody produced in rabbit IgG fraction of antiserum | AV44041 | 100μL | $490 |
| Sobetirome ≥98% | 30814 | 1mg | $43 |
| More product size | |||
| Melting point | 122 - 124°C |
|---|---|
| Boiling point | 510.2±45.0 °C(Predicted) |
| Density | 1.152±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble10mg/mL, clear |
| pka | 3.22±0.10(Predicted) |
| form | powder |
| color | white to beige |
| biological source | rabbit |
| InChI | InChI=1S/C20H24O4/c1-12(2)17-9-15(5-6-19(17)21)10-18-13(3)7-16(8-14(18)4)24-11-20(22)23/h5-9,12,21H,10-11H2,1-4H3,(H,22,23) |
| InChIKey | QNAZTOHXCZPOSA-UHFFFAOYSA-N |
| SMILES | C(O)(=O)COC1=CC(C)=C(CC2=CC=C(O)C(C(C)C)=C2)C(C)=C1 |
| FDA UNII | XQ31741E9Q |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
QRX 431 price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1900 | Sobetirome ≥98% (HPLC) | 211110-63-3 | 5mg | $121 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1900 | Sobetirome ≥98% (HPLC) | 211110-63-3 | 25mg | $491 | 2026-04-30 | Buy |
| Sigma-Aldrich | HPA014662 | Anti-SLC25A22 antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution | 100 μL | $667 | 2026-04-30 | Buy | |
| Sigma-Aldrich | AV44041 | Anti-SLC25A22 antibody produced in rabbit IgG fraction of antiserum | 211110-63-3 | 100μL | $490 | 2026-04-30 | Buy |
| Cayman Chemical | 30814 | Sobetirome ≥98% | 211110-63-3 | 1mg | $43 | 2026-04-30 | Buy |
QRX 431 Chemical Properties,Uses,Production
Uses
GC 1 is a high affinity thyroid receptor α (TRα) and TRβ agonist.
Definition
ChEBI: Sobetirome is a diarylmethane.
Biological Activity
sobetirome (3,5-dimethyl-4[(4'-hydroxy-3'-isopropylbenzyl)-phenoxy] acetic acid, also known as gc-1 and qrx-431, is a member of a class of compounds known as selective thyromimetics.it was firstly developed by thomas scanlan’s group at the university of california-san francisco (ucsf) in 1995 1.in cholesterol-fed rats, sobetirome was shown to lower plasma cholesterol in a dose-dependent manner by up to 75% of untreated controls. in hypercholesterolemic mice, sobetirome was failed to induce ldl receptor mrna expression. in different mouse models, sobetirome and t-0681 were shown to promote bile acid production and biliary sterol secretion. in cynomolgus monkeys, sobetirome was shown to reduce plasma cholesterol in a dose-dependent manner by up to 30%. both sobetirome and t-0681 were shown to increase hepatic expression of the hdl receptor (scavenger receptor-bi, sr-bi) in animals.in phase i
Biochem/physiol Actions
Sobetirome is also termed as 2-(4-(4-(benzyloxy)-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid/ GC-1. It has an inner-ring and negatively charged carboxylate groups at physiological pH. Sobetirome is considered as a cholesterol lowering agent in humans.
storage
Store at -20°C
References
1. tancevski i, demetz e, eller p. sobetirome: a selective thyromimetic for the treatment of dyslipidemia. recent pat cardiovasc drug discov. 2011 jan;6(1):16-9.
QRX 431 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xi an Biohorlden Industry Trade Co Ltd | +86-13636819721 | sales@horlden.com | China | 332 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32998 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29096 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19905 | 58 |
| Labnetwork lnc. | +86-27-50766799 +86-18062016861 | contact@labnetwork.com | China | 19981 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24569 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Supplier | Advantage |
|---|---|
| Xi an Biohorlden Industry Trade Co Ltd | 58 |
| Capot Chemical Co.,Ltd. | 60 |
| ATK CHEMICAL COMPANY LIMITED | 60 |
| BOC Sciences | 58 |
| Dideu Industries Group Limited | 58 |
| Nextpeptide Inc | 58 |
| Labnetwork lnc. | 58 |
| InvivoChem | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Lastest Price from QRX 431 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-13 | Sobetirome
211110-63-3
|
1g | 98% | 500 g | Xi an Biohorlden Industry Trade Co Ltd |
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- Sobetirome
211110-63-3
- 98%
- Xi an Biohorlden Industry Trade Co Ltd
