Kinsenoside
- CAS No.
- 151870-74-5
- Chemical Name:
- Kinsenoside
- Synonyms
- Kinsenoside;(+)-Kinsenoside;(4R)-4-(beta-D-Glucopyranosyloxy)dihydro-2(3H)-furanone;2(3H)-Furanone, 4-(β-D-glucopyranosyloxy)dihydro-, (4R)-;(4R)-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-one;(R)-4-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)dihydrofuran-2(3H)-one;Keap1-Nrf2,Inhibitor,pulposus,disc,degeneration,Kinsenoside,inhibit,cells,nucleus,Nrf2,Apoptosis,intervertebral
- CBNumber:
- CB22645474
- Molecular Formula:
- C10H16O8
- Molecular Weight:
- 264.23
- MDL Number:
- MFCD11100290
- MOL File:
- 151870-74-5.mol
| Product description | Number | Pack Size | Price |
| Kinsenoside ≥95% | 25144 | 1mg | $44 |
| Kinsenoside ≥95% | 25144 | 5mg | $193 |
| Kinsenoside ≥95% | 25144 | 10mg | $341 |
| Kinsenoside | K570200 | 10mg | $420 |
| Kinsenoside | 300531 | 25mg | $907 |
| More product size | |||
| Boiling point | 570.2±50.0 °C(Predicted) |
|---|---|
| Density | 1.59±0.1 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light |
| solubility |
DMF:14.0(Max Conc. mg/mL);52.98(Max Conc. mM) DMSO:33.0(Max Conc. mg/mL);124.89(Max Conc. mM) PBS (pH 7.2):10.0(Max Conc. mg/mL);37.85(Max Conc. mM) |
| form | A crystalline solid |
| pka | 12.81±0.70(Predicted) |
| color | White to light yellow |
| InChI | InChI=1/C10H16O8/c11-2-5-7(13)8(14)9(15)10(18-5)17-4-1-6(12)16-3-4/h4-5,7-11,13-15H,1-3H2/t4-,5-,7-,8+,9-,10-/s3 |
| InChIKey | MQEPWBMWFIVRPS-MUOXDHKLNA-N |
| SMILES | O1C[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)CC1=O |&1:2,4,6,9,11,13,r| |
Kinsenoside price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25144 | Kinsenoside ≥95% | 151870-74-5 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 25144 | Kinsenoside ≥95% | 151870-74-5 | 5mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 25144 | Kinsenoside ≥95% | 151870-74-5 | 10mg | $341 | 2024-03-01 | Buy |
| TRC | K570200 | Kinsenoside | 151870-74-5 | 10mg | $420 | 2021-12-16 | Buy |
| Usbiological | 300531 | Kinsenoside | 151870-74-5 | 25mg | $907 | 2021-12-16 | Buy |
Kinsenoside Chemical Properties,Uses,Production
Description
Kinsenoside is a glycoside originally isolated from A. formosanus that has diverse biological activities, including antihyperlipidemic, immunosuppressive, and anti-inflammatory properties. It increases lipolysis mediated by adipose triglyceride lipase and increases hydrolysis of triglycerides in C3H10T1/2 adipocytes. It also increases phosphorylation of peroxisome proliferator-activated receptor α (PPARα) and CREB as well as protein levels of SIRT1, PGC-1α, and carnitine palmitoyltransferase I. Kinsenoside downregulates the expression and phosphorylation of VEGF receptor 2 (VEGFR2) and inhibits crosstalk between the JAK2/STAT3 and PI3K/AKT signaling pathways in dendritic cells in vitro. It decreases the production of IFN-γ, IL-17, and TNF-α and increases the production of IL-10 in splenocytes isolated from mice with collagen-induced arthritis (CIA). Kinsenoside (300 mg/kg per day) decreases the expression of IL-1β, TNF-α, and matrix metalloproteinase-9 (MMP-9) and increases the expression of IL-10 in inflamed joints in a mouse model of collagen-induced arthritis and prevents paw edema and reduces the severity of arthritis.
Uses
Kinsenoside is an anti-hyperlipidemic agent isolated from the plant Anoect chilus.
Definition
ChEBI: (3R)-5-Oxotetrahydro-3-furanyl beta-D-glucopyranoside is a glycoside.
in vivo
Kinsenoside (10 mg/kg; ip; every 3 days for 4 weeks) promotes the expression of Nrf2 and ameliorates intervertebral disc degeneration (IDD) induced by Pentobarbital (50 mg/kg) in vivo in rat model[1].
Kinsenoside (100 mg/kg, 300 mg/kg; ip; 1 h before LPS induction) inhibits LPS (40 mg/kg; ip)-induced inflammatory model in mice[3].
References
[1] X M DU. Glycosidic constituents from in vitro Anoectochilus formosanus.[J]. Chemical & pharmaceutical bulletin, 2000, 48 11: 1803-1804. DOI: 10.1248/cpb.48.1803
[2] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[3] HUNG-BO HSIAO. Kinsenoside inhibits the inflammatory mediator release in a type-II collagen induced arthritis mouse model by regulating the T cells responses[J]. BMC Complementary and Alternative Medicine, 2016, 16 1. DOI: 10.1186/s12906-016-1054-8
[4] MING XIANG. Effects of kinsenoside, a potential immunosuppressive drug for autoimmune hepatitis, on dendritic cells/CD8+T cells communication in mice[J]. Hepatology, 2016, 64 6: 2135-2150. DOI: 10.1002/hep.28825
Kinsenoside Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Aktin Chemicals, Inc. | 028-85159085 | info@aktinchem.com | CHINA | 1025 | 58 |
View Lastest Price from Kinsenoside manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-25 | Kinsenoside
151870-74-5
|
US $63.00-243.00 / mg | 99.86% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Kinsenoside
151870-74-5
|
US $0.00 / mg | 20mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- Kinsenoside
151870-74-5
- US $63.00-243.00 / mg
- 99.86%
- TargetMol Chemicals Inc.
-
- Kinsenoside
151870-74-5
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
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