D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT
- CAS No.
- 103404-90-6
- Chemical Name:
- D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT
- Synonyms
- d-α-hydroxyglutaric acid disodium salt;sodiuM 2-hydroxypentanedioate;(r)-2-hydroxypentanedioic acid;Disodium (R)-2-hydroxyglutarate;(2R)-2-Hydroxypentanedioic acid;D-A-HYDROXYGLUTARIC ACID DISODIUM;SodiuM (R)-2-hydroxypentanedioate;D-α-Hydroxyglutaric acid disodium;isodium,(2R)-2-hydroxypentanedioate;D-α-Hydroxyglutaricaciddisodiumsalt
- CBNumber:
- CB2266017
- Molecular Formula:
- C5H9NaO5
- Molecular Weight:
- 172.11
- MDL Number:
- MFCD00069573
- MOL File:
- 103404-90-6.mol
- MSDS File:
- SDS
| Melting point | >291°C (dec.) |
|---|---|
| storage temp. | -20°C |
| solubility | PBS (pH 7.2): 10 mg/ml |
| form | A crystalline solid |
| color | White to light yellow |
| optical activity | [α]/D 8.5±1.5°, c = 1 in NaOH |
| Water Solubility | Soluble to 100 mM in water |
| BRN | 5318041 |
| Stability | Hygroscopic |
| InChI | InChI=1/C5H8O5.Na.H/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/t3-;;/s3 |
| InChIKey | DZHFTEDSQFPDPP-HWYNEVGZSA-L |
| SMILES | [C@H](O)(C(=O)O)CCC(=O)O.[NaH] |&1:0,r| |
| UNSPSC Code | 12352106 |
| NACRES | NA.25 |
D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 16859 | D-α-Hydroxyglutaric acid disodium salt ≥98.0% (GC) | 103404-90-6 | 10mg | $83.4 | 2025-07-31 | Buy |
| Sigma-Aldrich | 16859 | D-α-Hydroxyglutaric acid disodium salt ≥98.0% (GC) | 103404-90-6 | 50mg | $307.44 | 2025-07-31 | Buy |
| Cayman Chemical | 11605 | D-α-Hydroxyglutaric Acid (sodium salt) ≥95% | 103404-90-6 | 10mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 11605 | D-α-Hydroxyglutaric Acid (sodium salt) ≥95% | 103404-90-6 | 25mg | $109 | 2024-03-01 | Buy |
| Sigma-Aldrich | H8378 | D-α-Hydroxyglutaric acid disodium salt ≥95% (GC) | 103404-90-6 | 100mg | $495.41 | 2025-07-31 | Buy |
D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT Chemical Properties,Uses,Production
Description
D-α-Hydroxyglutaric Acid (D-2-HG) is an α-hydroxy acid that is over-produced in the human neurometabolic disease D-2-hydroxyglutaric aciduria (D-2-HGA). It is normally synthesized from 2-ketoglutarate (2-KG) by hydroxyacid-oxoacid transhydrogenase (HOT), although defects in HOT are not known to be associated with D-2-HGA. Instead, type I D-2-HGA involves mutations in D-2-hydroxyglutarate dehydrogenase, which converts D-2-HG back to 2-KG. Type II D-2-HGA results from gain-of-function mutations in isocitrate dehydrogenase 2, causing it to supplement HOT in converting 2-KG to D-2-HG. In bacteria, this α-hydroxy acid may be synthesized from oxalate and propionyl-coenzyme A by an α-hydroxyglutaric acid synthetase.
Chemical Properties
Pale Orange Solid
Uses
A potential inhibitor of glutamate carboxypeptidase.
Biochem/physiol Actions
Biomarker for inborn errors of metabolism and cancer
storage
Store at -20°C
References
[1] XUDONG FU. 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.[J]. Cell metabolism, 2015, 22 3: 508-515. DOI: 10.1016/j.cmet.2015.06.009
[2] ALEXANDRA LATINI. D-2-hydroxyglutaric acid induces oxidative stress in cerebral cortex of young rats[J]. European Journal of Neuroscience, 2003, 17 10: 2017-2022. DOI: 10.1046/j.1460-9568.2003.02639.x
[3] MARTIJN KRANENDIJK. IDH2 Mutations in Patients with d-2-Hydroxyglutaric Aciduria[J]. Science, 2010, 330 6002. DOI: 10.1126/science.1192632
[4] EDUARD A STRUYS. Mutations in the D-2-hydroxyglutarate dehydrogenase gene cause D-2-hydroxyglutaric aciduria.[J]. American journal of human genetics, 2005, 76 2: 358-360. DOI: 10.1086/427890
[5] HUI YANG. IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives.[J]. Clinical Cancer Research, 2012, 18 20: 5562-5571. DOI: 10.1158/1078-0432.ccr-12-1773
[6] WEI XU. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.[J]. Cancer Cell, 2011, 19 1: 17-30. DOI: 10.1016/j.ccr.2010.12.014
[7] RASHEDUZZAMAN CHOWDHURY. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.[J]. EMBO Reports, 2011, 12 5: 463-469. DOI: 10.1038/embor.2011.43
D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12222 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20503 | 58 |
View Lastest Price from D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-24 | D-α-Hydroxyglutaric acid disodium
103404-90-6
|
US $30.00-67.00 / mg | 97.16% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-08-02 | D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT
103404-90-6
|
US $1.00 / KG | 1KG | 95-99% | 500kg/month | Career Henan Chemical Co |
-
- D-α-Hydroxyglutaric acid disodium
103404-90-6
- US $30.00-67.00 / mg
- 97.16%
- TargetMol Chemicals Inc.
-
- D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT
103404-90-6
- US $1.00 / KG
- 95-99%
- Career Henan Chemical Co
