MK 5172 hydrate
- CAS No.
- 1350462-55-3
- Chemical Name:
- MK 5172 hydrate
- Synonyms
- Anapivir;MK5172 hydrate;MK 5172 hydrate;MK-5172 (hydrate);Grazoprevir hydrate;Grazoprevir hydrate (MK-5172 hydrate);GRAZOPREVIR HYDRATE;MK5172 HYDRATE;MK 5172 HYDRATE;(33R,35S,91R,92R,5S)-5-(tert-butyl)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphane-35-carboxamide Hydrate;Cyclopropanecarboxamide, N-[[[(1R,2R)-2-[5-(3-hydroxy-6-methoxy-2-quinoxalinyl)pentyl]cyclopropyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenyl-, cyclic (1→2)-ether, hydrate (1:1), (1R,2S)-
- CBNumber:
- CB22666659
- Molecular Formula:
- C38H50N6O9S.H2O
- Molecular Weight:
- 784.91868
- MDL Number:
- MFCD25976702
- MOL File:
- 1350462-55-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Grazoprevirhydrate 99.10% | CS-1376 | 5mg | $108 |
| Grazoprevirhydrate 99.10% | CS-1376 | 10mg | $168 |
| Grazoprevirhydrate 99.10% | CS-1376 | 50mg | $540 |
| Grazoprevirhydrate 99.10% | CS-1376 | 100mg | $780 |
| MK-5172hydrate 98+% | CD31003789 | 50mg | $1050 |
| More product size | |||
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO : 50 mg/mL (63.70 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) |
| form | Powder |
| color | White to off-white |
| FDA UNII | 4O2AB118LA |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H373 |
| Precautionary statements | P260-P314-P501 |
MK 5172 hydrate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1376 | Grazoprevirhydrate 99.10% | 1350462-55-3 | 5mg | $108 | 2021-12-16 | Buy |
| ChemScene | CS-1376 | Grazoprevirhydrate 99.10% | 1350462-55-3 | 10mg | $168 | 2021-12-16 | Buy |
| ChemScene | CS-1376 | Grazoprevirhydrate 99.10% | 1350462-55-3 | 50mg | $540 | 2021-12-16 | Buy |
| ChemScene | CS-1376 | Grazoprevirhydrate 99.10% | 1350462-55-3 | 100mg | $780 | 2021-12-16 | Buy |
| Crysdot | CD31003789 | MK-5172hydrate 98+% | 1350462-55-3 | 50mg | $1050 | 2021-12-16 | Buy |
MK 5172 hydrate Chemical Properties,Uses,Production
Uses
Grazoprevir hydrate (MK-5172 hydrate) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively[1][2]. Grazoprevir hydrate inhibits SARS-CoV-2 3CLpro activity[3].
in vivo
Grazoprevir (MK-5172) demonstrates efficacy in vivo against chronic-HCV-infected chimpanzees[1]. When dosed to dogs, Grazoprevir (MK-5172) shows low clearance of 5 mL/min/kg and a 3 h half-life after iv dosing and has good plasma exposure (AUC=0.4 μM h) after a 1 mg/kg oral dose. Dog liver biopsy studies showed that the liver concentration of Grazoprevir after the 1 mg/kg oral dose is 1.4 μM at the 24 h time point. Similar to its behavior in rats, Grazoprevir demonstrates effective partitioning into liver tissue and maintains high liver concentration, relative to potency, 24 h after oral dosing in dogs[2].
References
[1] Steven Harper , John A. McCauley , Michael T. Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor. ACS Med. Chem. Lett., 2012, 3 (4), pp 332-336
[2] Summa V, Ludmerer SW, McCauley JA, MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants. Antimicrob Agents Chemother. 2012 Aug;56(8):4161-7. DOI:10.1128/AAC.00324-12
[3] Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212. DOI:10.1038/s41392-021-00628-x
MK 5172 hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29799 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32434 | 58 |
| ChemExpress | +86-19370970350 +86-021-58950125 | info@chemexpress.com | China | 787 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19961 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Henan Rane Chemical Co., Ltd. | +8618738066252 | info@ranechem.com | China | 3034 | 58 |
| Z IntellecChem& Tech. Co., Ltd | 15050866711 | contact@zintellec.com | China | 101 | 62 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| Supplier | Advantage |
|---|---|
| career henan chemical co | 58 |
| TargetMol Chemicals Inc. | 58 |
| ChemExpress | 58 |
| InvivoChem | 58 |
| Aladdin Scientific | 58 |
| TargetMol Chemicals Inc. | 58 |
| Amadis Chemical Company Limited | 58 |
| Henan Rane Chemical Co., Ltd. | 58 |
| Z IntellecChem& Tech. Co., Ltd | 62 |
| Haoyuan Chemexpress Co., Ltd. | 61 |
View Lastest Price from MK 5172 hydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-21 | Grazoprevir hydrate
1350462-55-3
|
US $0.00-0.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2020-02-14 | MK 5172 hydrate
1350462-55-3
|
US $7.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- Grazoprevir hydrate
1350462-55-3
- US $0.00-0.00 / mg
- TargetMol Chemicals Inc.
-
- MK 5172 hydrate
1350462-55-3
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
