BenzaMide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro-
- CAS No.
- 1269055-85-7
- Chemical Name:
- BenzaMide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro-
- Synonyms
- FAB-001;MUT056399;compound I;MUT-056399 (FAB-001);MUT056399, 10 mM in DMSO;4-(4-Ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzamide;BenzaMide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro-;Inhibitor,MUT056399,inhibit,Bacterial,Fab 001,MUT-056399,Fab001,MUT 056399
- CBNumber:
- CB22667641
- Molecular Formula:
- C15H13F2NO3
- Molecular Weight:
- 293.27
- MDL Number:
- MFCD25977011
- MOL File:
- 1269055-85-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| MUT056399 99.87% | CS-5339 | 5mg | $217 |
| MUT056399 99.87% | CS-5339 | 10mg | $347 |
| MUT056399 99.87% | CS-5339 | 25mg | $596 |
| MUT056399 99.87% | CS-5339 | 50mg | $856 |
| MUT056399 99.87% | CS-5339 | 100mg | $1159 |
| More product size | |||
| Boiling point | 373.8±42.0 °C(Predicted) |
|---|---|
| Density | 1.342±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 31 mg/mL (105.70 mM) |
| form | Solid |
| pka | 8.93±0.48(Predicted) |
| color | White to off-white |
| FDA UNII | B52RPV7VRM |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
BenzaMide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-5339 | MUT056399 99.87% | 1269055-85-7 | 5mg | $217 | 2026-06-04 | Buy |
| ChemScene | CS-5339 | MUT056399 99.87% | 1269055-85-7 | 10mg | $347 | 2026-06-04 | Buy |
| ChemScene | CS-5339 | MUT056399 99.87% | 1269055-85-7 | 25mg | $596 | 2026-06-04 | Buy |
| ChemScene | CS-5339 | MUT056399 99.87% | 1269055-85-7 | 50mg | $856 | 2026-06-04 | Buy |
| ChemScene | CS-5339 | MUT056399 99.87% | 1269055-85-7 | 100mg | $1159 | 2026-06-04 | Buy |
BenzaMide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro- Chemical Properties,Uses,Production
Uses
MUT056399 (Fab-001) is a highly potent inhibitor of the FabI enzyme of both S. aureus and E. coli with 50% inhibitory concentration IC50s of 12 nM and 58 nM, respectively.
in vivo
MUT056399 (Fab-001), administered subcutaneously, protected mice from a lethal systemic infection induced by MSSA, MRSA, and vancomycin-intermediate S. aureus strains (50% effective doses ranging from 19.3 mg/kg/day to 49.6 mg/kg/day). In the nonneutropenic murine thigh infection model, the same treatment with MUT056399 reduced the bacterial multiplication of MSSA and MRSA in the thighs of immunocompetent mice.
References
[1] Escaich S, et al. The MUT056399 inhibitor of FabI is a new antistaphylococcal compound. Antimicrob Agents Chemother. 2011 Oct;55(10):4692-7. DOI:10.1128/AAC.01248-10
[2] Schiebel J, et al. An ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognitionand reduction. Biochemistry. 2015 Mar 17;54(10):1943-55. DOI:10.1021/bi5014358
BenzaMide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro- Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +8618118463618 | sales1@artkmedchem.com | China | 39021 | 58 |
| Sichuan Yuehe Biopharmaceutical Co., Ltd | +86-838-2806918 +86-18030702676 | sales@yuehepharm.com | China | 184 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
