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ChemicalBook >> CAS DataBase List >>Benzeneacetic acid, 2,3,4-triMethoxy-6-(1-oxooctyl)-, ethyl ester

Benzeneacetic acid, 2,3,4-triMethoxy-6-(1-oxooctyl)-, ethyl ester

Benzeneacetic acid, 2,3,4-triMethoxy-6-(1-oxooctyl)-, ethyl ester Structure
Benzeneacetic acid, 2,3,4-triMethoxy-6-(1-oxooctyl)-, ethyl ester structure
CAS No.
1258275-73-8
Chemical Name:
Benzeneacetic acid, 2,3,4-triMethoxy-6-(1-oxooctyl)-, ethyl ester
Synonyms
(-)-Prangeferol;TMPA, 10 mM in DMSO;Ethyl (2,3,4-trimethoxy-6-octanoylphenyl)acetate;Ethyl 2-(2,3,4-trimethoxy-6-octanoylphenyl)acetate;Benzeneacetic acid, 2,3,4-triMethoxy-6-(1-oxooctyl)-, ethyl ester
CBNumber:
CB22668693
Molecular Formula:
C21H32O6
Molecular Weight:
380.48
MDL Number:
MFCD28160842
MOL File:
1258275-73-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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Benzeneacetic acid, 2,3,4-triMethoxy-6-(1-oxooctyl)-, ethyl ester Properties

Boiling point 480.0±45.0 °C(Predicted)
Density 1.053±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : ≥ 100 mg/mL (262.83 mM);Water : < 0.1 mg/mL (insoluble)
form Solid
color Light yellow to yellow

Benzeneacetic acid, 2,3,4-triMethoxy-6-(1-oxooctyl)-, ethyl ester price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 217604 Nur77 LBD Antagonist (TMPA) 1258275-73-8 5mg $568 2026-06-03 Buy
Usbiological 217604 Nur77 LBD Antagonist (TMPA) 1258275-73-8 10mg $911 2026-06-03 Buy
Usbiological 217604 Nur77 LBD Antagonist (TMPA) 1258275-73-8 50mg $1795 2026-06-03 Buy
ChemScene CS-7618 TMPA 98.40% 1258275-73-8 2mg $143 2026-06-04 Buy
ChemScene CS-7618 TMPA 98.40% 1258275-73-8 5mg $233 2026-06-04 Buy
Product number Packaging Price Buy
217604 5mg $568 Buy
217604 10mg $911 Buy
217604 50mg $1795 Buy
CS-7618 2mg $143 Buy
CS-7618 5mg $233 Buy

Benzeneacetic acid, 2,3,4-triMethoxy-6-(1-oxooctyl)-, ethyl ester Chemical Properties, Uses, Production

Uses

TMPA is a high-affinity Nur77 antagonist that binds to Nur77 leading to the release and shuttling of LKB1 in the cytoplasm to activate AMPKα. TMPA effectively lowers blood glucose and attenuates insulin resistance in type II db/db, high-fat diet and streptozotocin-induced diabetic mice. TMPA reduces RICD (restimulation-induced cell death) in human T cells, can also be used in studies of cancer and T-cell apoptosis dysregulation[1][2].

Definition

ChEBI: Ethyl (2,3,4-trimethoxy-6-octanoylphenyl)acetate is an aromatic ketone.

in vivo

TMPA (50 mg/kg; i.p.; single daily for 19 days) is capable of lowering blood glucose and improving glucose tolerance in type II diabetic mice[1].

Animal Model:Male C57BL/KsJ-Leprdb/Leprdb (db/db) mice (10-week-old; type II diabetic model)[1].
Dosage:50 mg/kg
Administration:Intraperitoneal injection; single daily for 19 days.
Result:Significantly reduced blood glucose at day 7 and persisted during the remainder of the test.
Increased the amount of phosphorylated AMPKα in the liver of mice.

IC 50

Nur77/NR4A1

References

[1] Zhan YY, et al. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nat Chem Biol. 2012 Nov;8(11):897-904. DOI:10.1038/nchembio.1069
[2] Recher, et al. Modulation of T-cell apoptosis by small molecule compounds targeting the nuclear orphan receptor Nur 77. (2018).

Benzeneacetic acid, 2,3,4-triMethoxy-6-(1-oxooctyl)-, ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

Benzeneacetic acid, 2,3,4-triMethoxy-6-(1-oxooctyl)-, ethyl ester Suppliers

Global Suppliers ( 41)
Supplier Tel Email Country ProdList Advantage
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD 13816107857 sales@fortunechem-sh.com China 981 58
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
ShangHai KenEn Chemical Technology Co., Ltd. 13120367189;18621755571 mychess007@163.com China 1994 55
SPIRO PHARMA eric_feng1954@126.com China 9239 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai Changyan Chem & Tech Co., Ltd. 021-20242659 18930833303 sales@changyanchem.cn China 4998 55
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9783 55
Shanghai SuperLan Chemcial Technique Centre 0-2022843681 15618226720 chaolaichem@foxmail.com China 9996 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Supplier Advantage
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD 58
MedChemexpress LLC 58
ShangHai KenEn Chemical Technology Co., Ltd. 55
SPIRO PHARMA 55
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Changyan Chem & Tech Co., Ltd. 55
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Shanghai SuperLan Chemcial Technique Centre 58
TargetMol Chemicals Inc. 58

View Latest Price from Benzeneacetic acid, 2,3,4-triMethoxy-6-(1-oxooctyl)-, ethyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TMPA pictures 2026-07-27 TMPA
1258275-73-8
 $73.00-289.00 99.21% 10g TargetMol Chemicals Inc.
TMPA pictures 2026-07-27 TMPA
1258275-73-8
 $73.00-289.00 99.21% 10g TargetMol Chemicals Inc.
  • TMPA pictures
  • TMPA
    1258275-73-8
  • $73.00-289.00
  • 99.21%
  • TargetMol Chemicals Inc.
  • TMPA pictures
  • TMPA
    1258275-73-8
  • $73.00-289.00
  • 99.21%
  • TargetMol Chemicals Inc.

Benzeneacetic acid, 2,3,4-triMethoxy-6-(1-oxooctyl)-, ethyl ester Spectrum

Benzeneacetic acid, 2,3,4-triMethoxy-6-(1-oxooctyl)-, ethyl ester(1258275-73-8)1HNMR

1258275-73-8 (Benzeneacetic acid, 2,3,4-triMethoxy-6-(1-oxooctyl)-, ethyl ester) Related Search:

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Benzeneacetic acid, 2,3,4-triMethoxy-6-(1-oxooctyl)-, ethyl ester Ethyl (2,3,4-trimethoxy-6-octanoylphenyl)acetate (-)-Prangeferol Ethyl 2-(2,3,4-trimethoxy-6-octanoylphenyl)acetate TMPA, 10 mM in DMSO 1258275-73-8