Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine

5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine

5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine Structure
5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine structure
CAS No.
1150618-36-2
Chemical Name:
5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine
Synonyms
5-Bromo-3-(trifluoromethyl)-7-azaindole;5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 5-bromo-3-(trifluoromethyl)-
CBNumber:
CB22672957
Molecular Formula:
C8H4BrF3N2
Molecular Weight:
265.03
MDL Number:
MFCD12024503
MOL File:
1150618-36-2.mol
Last updated:2025-10-14 17:28:45
Product description Number Pack Size Price
5-Bromo-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 95+% PC201031 100mg $174
5-Bromo-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 95+% PC201031 250mg $277
5-Bromo-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 95.0% 3H31-B-0F 100mg $279
5-Bromo-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 95.0% 3H31-B-0F 250mg $444
5-BROMO-3-(TRIFLUOROMETHYL)-1H-PYRROLO[2,3-B]PYRIDINE 95.00% HCH0295052 5MG $496.63
Request For Quotation

5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine Properties

Density 1.830±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka 11.08±0.40(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501
HS Code  2933399990

5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC201031 5-Bromo-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 95+% 1150618-36-2 100mg $174 2021-12-16 Buy
Apolloscientific PC201031 5-Bromo-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 95+% 1150618-36-2 250mg $277 2021-12-16 Buy
SynQuest Laboratories 3H31-B-0F 5-Bromo-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 95.0% 1150618-36-2 100mg $279 2021-12-16 Buy
SynQuest Laboratories 3H31-B-0F 5-Bromo-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 95.0% 1150618-36-2 250mg $444 2021-12-16 Buy
American Custom Chemicals Corporation HCH0295052 5-BROMO-3-(TRIFLUOROMETHYL)-1H-PYRROLO[2,3-B]PYRIDINE 95.00% 1150618-36-2 5MG $496.63 2021-12-16 Buy
Product number Packaging Price Buy
PC201031 100mg $174 Buy
PC201031 250mg $277 Buy
3H31-B-0F 100mg $279 Buy
3H31-B-0F 250mg $444 Buy
HCH0295052 5MG $496.63 Buy

5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine Chemical Properties,Uses,Production

Synthesis

3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine

892414-47-0

5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine

1150618-36-2

General procedure for the synthesis of 3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine from 3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine: Bromine (36.2 g, 0.2 mol) was added slowly and dropwise over a period of 1 h to dry dichloromethane (200 mL) that was cooled to -5°C. The reaction was followed by the addition of bromine (36.2 g, 0.2 mol). Subsequently, a solution of 3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine (25 g, 0.13 mol) and pyridine (17 mL) in dichloromethane (500 mL) was added dropwise. After dropwise addition, the reaction mixture was stirred at -5°C for 45 minutes. After completion of the reaction, the mixture was poured into a mixture of saturated aqueous sodium bicarbonate and sodium thiosulfate and extracted with ethyl acetate (3 x 1000 mL). The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate and subsequently concentrated to dryness under vacuum. The resulting residue was purified by recrystallization (ethyl acetate: petroleum ether = 8:1) to afford the target product 5-bromo-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine (7.55 g, 21% yield). The structure of the product was confirmed by NMR hydrogen spectroscopy (400 MHz, DMSO-d6): δ 12.76 (s, 1H), 8.44 (s, 1H), 8.23 (m, 2H).

References

[1] Patent: WO2014/111496, 2014, A1. Location in patent: Page/Page column 105; 106
[2] Patent: WO2016/142310, 2016, A1. Location in patent: Page/Page column 72

5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine Preparation Products And Raw materials

Raw materials

3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine Dichloromethane Pyridine

Preparation Products

5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine Suppliers

Global( 39)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Cochemical Co. Ltd. 		+86-029-86115547 +86-17791676824 sales@cochemical.com China 3952 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
ZEROSCHEM.CO.,LTD. 10-61256048 13810278579 sales@zeroschem.com China 1360 59
Cochemical Ltd. 029-86115547 17791676824 sales@cochemical.com China 3014 58
Shanghai HuanChuan Industry Co.,Ltd. 021-61478794 sales@hcshhai.com China 9793 50
Cool Pharm, Ltd 021-60455363 18019463053 sales@coolpharm.com China 12346 58
skychemical Co.Ltd 021-20960837,QQ1332204249 sales@skychemical.com China 3341 55
Aikon International Limited 025-66061636 18013972705 qqyang@aikonchem.com China 15815 58
3A Chemicals 400-668-9898 service@3achem.com China 20557 58
Supplier Advantage
Aladdin Scientific 		58
Cochemical Co. Ltd. 		58
Amadis Chemical Company Limited 		58
ZEROSCHEM.CO.,LTD. 59
Cochemical Ltd. 58
Shanghai HuanChuan Industry Co.,Ltd. 50
Cool Pharm, Ltd 58
skychemical Co.Ltd 55
Aikon International Limited 58
3A Chemicals 58

5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine Spectrum

5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine(1150618-36-2)1HNMR5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine(1150618-36-2)19FNMR
5-broMo-3-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-3-(trifluoromethyl)- 5-Bromo-3-(trifluoromethyl)-7-azaindole 1150618-36-2