Isradipine | 75695-93-1

Isradipine Properties

Melting point	166-1680C
Boiling point	501.9±60.0 °C(Predicted)
Density	1.249±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: ~26 mg/mL
form	solid
pka	2.56±0.70(Predicted)
color	yellow
Merck	14,5240
BCS Class	2/4
Stability	Stable for 2 years from date of purchsae as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Major Application	pharmaceutical (small molecule)
InChI	InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3
InChIKey	HMJIYCCIJYRONP-UHFFFAOYSA-N
SMILES	C1(C)NC(C)=C(C(OC(C)C)=O)C(C2C3C(C=CC=2)=NON=3)C=1C(OC)=O
CAS DataBase Reference	75695-93-1(CAS DataBase Reference)
FDA UNII	YO1UK1S598
ATC code	C08CA03
NIST Chemistry Reference	Isradipine(75695-93-1)
UNSPSC Code	41116107
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H413
Precautionary statements	P501-P273
Safety Statements	22-24/25
WGK Germany	3
HS Code	2934990002
Storage Class	11 - Combustible Solids

Isradipine price More Price(71)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0000366	Isradipine European Pharmacopoeia (EP) Reference Standard	75695-93-1	125 mg	$127	2026-04-30	Buy
Sigma-Aldrich	I6658	Isradipine ≥98% (HPLC), solid	75695-93-1	5mg	$245	2026-04-30	Buy
Sigma-Aldrich	5.08507	Isradipine - CAS 75695-93-1 - Calbiochem A voltage gated calcium channel gating inhibitor of the dihydropyridine class.	75695-93-1	10MG	$132	2026-04-30	Buy
Sigma-Aldrich	1354207	Isradipine United States Pharmacopeia (USP) Reference Standard	75695-93-1	200mg	$416	2026-04-30	Buy
TCI Chemical	I0876	Isradipine >98.0%(HPLC)	75695-93-1	25mg	$113	2026-04-30	Buy

Product number	Packaging	Price	Buy
Y0000366	125 mg	$127	Buy
I6658	5mg	$245	Buy
5.08507	10MG	$132	Buy
1354207	200mg	$416	Buy
I0876	25mg	$113	Buy

Isradipine Chemical Properties,Uses,Production

Description

Isradipine is a long-acting calcium blocker effective in the treatment of essential hypertension. The advantages of isradipine as compared with other dihydropyridine calcium antagonists include a "gentle" onset and fewer contraindications. It can be taken by patients with diabetes mellitus, chronic obstructive airway diseases, gout, congestive heart failure or ischemic heart disease.

Chemical Properties

Yellow Solid

Originator

Sandoz (Switzerland)

Uses

Isradipine is a L-type calcium channel blocker, Isradipine has anti-atherosclerotic effects in animals and improves endothelium-mediated nitric oxide (NO)-dependent vasodilation in vitro. Additional studies indicate that Isradipine may provide a neuroprotective effect in a rat model of focal ischemia and that Isradipine produces a dose-dependent sparing of dopamine neuronal fibers and cell bodies.

Uses

nonsedating H1-antihistamine

Uses

Dihydropyridine calcium channel blocker. Antihypertensive; antianginal

Definition

ChEBI: Isradipine is an isopropyl ester, a methyl ester, a dihydropyridine and a benzoxadiazole.

brand name

Dynacirc (Reliant);Prescal.

General Description

Isradipine, 4-(4-benzofuranazyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester (DynaCirc), is another second-generationdihydropyridine-type channel blocker. This drug, like theother second-generation analogs, is more selective for vascularsmooth muscle than for myocardial tissue. It is effectivein the treatment of stable angina, reducing the frequencyof anginal attacks and the need to use nitroglycerin.

Biological Activity

Potent and selective L-type voltage-gated Ca 2+ channel blocker. EC 50 and pA 2 values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca 2+ -induced contractions of rabbit aorta respectively; EC 25 = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo , exerting primary effects on vascular tissue with secondary negative chronotropic action.

Biochem/physiol Actions

L-type calcium channel blocker (also referred to as dihydropyridine-type calcium channel blocker); antihypertensive.

storage

Room temperature

References

[1] C. BRACHT. Isradipine improves endothelium-dependent vasodilation in normotensive coronary artery disease patients with hypercholesterolemia[J]. Journal of Hypertension, 2001, 19 1: 899-905. DOI:10.1097/00004872-200105000-00010
[2] S CHANDRA. Use of diffusion-weighted MRI and neurological deficit scores to demonstrate beneficial effects of isradipine in a rat model of focal ischemia.[J]. Pharmacology, 1999, 58 6: 292-299. DOI:10.1159/000028294
[3] ARKO T, BOYLE T, DALEY D M, et al. Industry Study 5240-14: Final Reports Munitions[C]. 1900: 0. DOI:10.21236/ada425314

Isradipine Preparation Products And Raw materials

Raw materials

Isopropyl acetoacetate Benzofuroxan Methyl 3-aminocrotonate

Preparation Products

Isradipine Suppliers

Global( 307)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Junye chemical Co., Ltd	021-021-50318666 18516602538	shlip@163.com	China	58	58
sinopharm	13856035343	1074637616@qq.com	China	20	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Ascent Scientific	4401179829988	customerservice@ascentscientific.co.uk	United Kingdom	279	60
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2110	70

Supplier	Advantage
Shanghai Junye chemical Co., Ltd	58
sinopharm	58
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chembest Research Laboratories Limited	61
TCI (Shanghai) Development Co., Ltd.	81
Ascent Scientific	60
Pure Chemistry Scientific Inc.	62
Adamas Reagent, Ltd.	59
LGM Pharma	70

View Lastest Price from Isradipine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-11	Isradipine 75695-93-1		1G	98%min	30kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-08-06	Isradipine 75695-93-1	$33.00-98.00		99.95%	10g	TargetMol Chemicals Inc.
2026-08-06	Isradipine 75695-93-1	$33.00-98.00		99.95%	10g	TargetMol Chemicals Inc.

Isradipine
75695-93-1
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Isradipine
75695-93-1
$33.00-98.00
99.95%
TargetMol Chemicals Inc.

Isradipine
75695-93-1
$33.00-98.00
99.95%
TargetMol Chemicals Inc.

Isradipine Spectrum

Isradipine(75695-93-1)¹HNMR

75695-93-1(Isradipine)Related Search:

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Isradipine Impurity 2（Isradipine EP Impurity B） Elacridar Ebselen Bendamustine Lercanidipine

Oxiracetam Benzofuroxan 2,6-Dimethyl-3,5-pyridinedicarboxylic acid

1of4

PN-200-110 Presca Prescal 4-(4-Benzofurazanyl)-2，6-dimethyl-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl 1-methylethyl ester 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic [chemical name] acid methyl 1-methylethyl ester Dynacrine Iomir Rebfiden 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester 4-(Benzofurazan-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-isopropyl ester PN-200-100 [R,(-)]-4-(Benzofurazan-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester Isradipine CS-139 (4R)-4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-propan-2-yl ester Dynacirc CR PN 200-110;DYNACIRC; LOMIR; PRESCAL; DYNACIRC CR; Isradipin Clivoten DynaCirc Esradin Isrodipine Lomir Isradipine Solution, 100ppm 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylicacidmethyl1-methylethylester Isradipine (200 mg) 3-Methyl 5-propan-2-yl (4R)-4-(2,1,3-benzoxadiazol-4-yl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylate Isradipine(Dynacirc) Isradipine API 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester Isradipine, >=99% 3-Isopropyl 5-methyl 4-(benzo[c][1,2,5]oxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-di 4-(4-BENZOFURAZANYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID METHYL 1-METHYLETHYL ESTER 4-(2,1,3-BENZOXADIAZOL-4-YL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINECARBOXYLIC ACID METHYL 1-METHYLETHYL ESTER Isradipine> Isradipine CRS 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3-methyl 5-(1-methylethyl) ester 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Isopropyl Methyl Ester Isopropyl Methyl 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimet Isopropyl Methyl 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Isradipine USP/EP/BP Isradipine (PN 200-110) IsradipineQ: What is Isradipine Q: What is the CAS Number of Isradipine Q: What is the storage condition of Isradipine Q: What are the applications of Isradipine 4-(4-BChemicalbookenzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic[chemicalname]acidmethyl1-methylethylester Isradipine (1354207) Isopropyl methyl(±)-4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Isradipine in methanol Isradipine, L-type Ca2+ channel blocker Isradipine, 10 mM in DMSO Isradipine for peak identification CRS 75695-93-1 75696-93-1 75695-63-1 C19H15N3O5D6 ALLEGRA Ion Channels Calcium channel Intermediates & Fine Chemicals