4-BroMo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
- CAS No.
- 1022158-35-5
- Chemical Name:
- 4-BroMo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
- Synonyms
- 4-bromo-1-(oxan-2-yl)indazole;4-bromo-1-(oxan-2-yl)-1H-indazole;4-bromo-1-(oxepan-2-yl)-1H-indazole;4-Bromo-1-(tetrahydropyran-2-yl)-1H-indazole;4-BroMo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole;1H-Indazole, 4-bromo-1-(tetrahydro-2H-pyran-2-yl)-
- CBNumber:
- CB22704388
- Molecular Formula:
- C12H13BrN2O
- Molecular Weight:
- 281.15
- MDL Number:
- MFCD22380249
- MOL File:
- 1022158-35-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H332-H312-H302-H319-H315 |
| Precautionary statements | P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P280-P302+P352-P312-P322-P363-P501-P264-P280-P302+P352-P321-P332+P313-P362 |
4-BroMo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B678268 | 4-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole | 1022158-35-5 | 500mg | $220 | 2021-12-16 | Buy |
| TRC | B678268 | 4-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole | 1022158-35-5 | 100mg | $65 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H56-9-70 | 4-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole | 1022158-35-5 | 250mg | $75 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0419512 | 4-BROMO-1-(TETRAHYDRO-2H-PYRAN-2-YL)-1H-INDAZOLE 95.00% | 1022158-35-5 | 5MG | $505.3 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H56-9-70 | 4-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole | 1022158-35-5 | 1g | $225 | 2021-12-16 | Buy |
4-BroMo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole Chemical Properties,Uses,Production
Synthesis
110-87-2
186407-74-9
1022158-35-5
The general procedure for the synthesis of 4-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole from 3,4-dihydro-2H-pyran and 4-bromo-1H-indazole was as follows: 3,4-dihydro-2H-pyran (5.36 mL, 58.57 mmol) was added to a solution of 3,4-dihydro-2H-pyran (5.36 mL, 58.57 mmol) containing 4-bromo-1H-indazole (5.77 g, 29.3 mmol) and 4-bromo-1H-sulphonic acid ( 0.176 g, 1.02 mmol) in a solution of ethyl acetate (60 mL). The reaction mixture was heated and stirred at 70 °C for 16 hours. After the reaction was completed, the mixture was cooled to room temperature and neutralized by adding saturated aqueous sodium bicarbonate solution (50 mL). The organic and aqueous phases were separated and the aqueous phase was extracted with ethyl acetate (10 mL). The organic layers were combined and washed sequentially with saturated aqueous sodium bicarbonate (10 mL) and saturated aqueous sodium chloride (10 mL). The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting brown oil was purified by fast silica gel column chromatography with the eluent being a heptane solution of 10% ethyl acetate. The product fraction was collected and the solvent was evaporated under reduced pressure to give 4-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole (7.78 g, 94% yield) as a white solid. The product was confirmed by 1H NMR (400 MHz, CDCl3, 30 °C): δ 1.60-1.88 (3H, m), 2.03-2.23 (2H, m), 2.55 (1H, dddd), 3.73 (1H, dddd), 4.00 (1H, dddd), 5.71 (1H, dddd), 7.19-7.24 (1H, m), and 7.32 (1H, dd), 7.55 (1H, dd), 8.03 (1H, d).
References
[1] Patent: WO2017/182495, 2017, A1. Location in patent: Page/Page column 114-115
[2] Patent: WO2008/51494, 2008, A1. Location in patent: Page/Page column 159
[3] Asian Journal of Chemistry, 2011, vol. 23, # 1, p. 451 - 454
[4] Patent: US2018/111931, 2018, A1. Location in patent: Paragraph 0882; 0883
[5] Synlett, 2009, # 4, p. 615 - 619
4-BroMo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Lianhe Aigen Pharmatech Co.,Ltd. | +86-18918657159; +undefined+undefined18918657159 | sales@lianhe-aigen.com | China | 317 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39927 | 58 |
| Shanghai Hanhong Scientific Co., Ltd. | +undefined17612118332 | Lucky@hanhonggroup.com | China | 5844 | 58 |
| Soochow Chirally Material Science and Technology Co.,Ltd | +86-51266834346 +86-17751128648 | sales@krl-tech.com | China | 738 | 58 |
| ROSEWA HOLDING GROUP CO.,LIMITED | +86-023-62871537 | sales@rosewachem.com | China | 2801 | 58 |
| Chengdu Feibo Pharm Technology Co., Ltd | +86 028-84641798 15982321820 | abby@arkpharm.com | China | 10000 | 58 |
| ChemShuttle, Inc. | 0150-83588313-811 18800520310 | sales@chemshuttle.com | China | 2999 | 62 |
