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XEN445

XEN445 Structure
XEN445 structure
CAS No.
1515856-92-4
Chemical Name:
XEN445
Synonyms
XEN445;CS-1251;XEN445 ，S7457;XEN 445, >=98%;XEN 445; XEN-445;XEN445 >=98% (HPLC);XEN445, 10 mM in DMSO;Inhibitor,inhibit,XEN445;2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid;(S)-2-(3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid
CBNumber:
CB22715681
Molecular Formula:
C18H17F3N2O3
Molecular Weight:
366.33
MDL Number:
MFCD28166367
MOL File:
1515856-92-4.mol
Last updated:2025-09-16 21:24:52
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XEN445 Properties

Boiling point 490.9±45.0 °C(Predicted)
Density 1.40±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 25 mg/ml; Ethanol: 14 mg/ml
form A crystalline solid
pka 3.35±0.36(Predicted)
color Light brown to brown
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

XEN445 price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1324 XEN445 ≥98% (HPLC) 1515856-92-4 5mg $82.4 2025-07-31 Buy
Sigma-Aldrich SML1324 XEN445 ≥98% (HPLC) 1515856-92-4 25mg $404 2025-07-31 Buy
Cayman Chemical 19144 XEN445 ≥98% 1515856-92-4 1mg $32 2024-03-01 Buy
Cayman Chemical 19144 XEN445 ≥98% 1515856-92-4 5mg $97 2024-03-01 Buy
Cayman Chemical 19144 XEN445 ≥98% 1515856-92-4 10mg $184 2024-03-01 Buy
Product number Packaging Price Buy
SML1324 5mg $82.4 Buy
SML1324 25mg $404 Buy
19144 1mg $32 Buy
19144 5mg $97 Buy
19144 10mg $184 Buy

XEN445 Chemical Properties,Uses,Production

Description

Endothelial lipase, a member of the triglyceride lipase gene family expressed in endothelial cells, prefers phospholipid-enriched high-density lipoprotein (HDL) over triglyceride as a substrate. XEN445 is an endothelial lipase inhibitor (IC50 = 237 nM) that demonstrates selectivity for endothelial lipase compared to lipoprotein and hepatic lipases (IC50s = 20 and 9.5 μM, respectivley). An oral dose of 30 mg/kg XEN445 is reported to increase HDL cholesterol concentrations by 16% after three days and by 30% after nine days dosing in wild-type mice.

Uses

XEN445 is a potent and selective endothelial lipase inhibitor.

References

[1] SHAOYI SUN . Discovery of XEN445: A potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice[J]. Bioorganic & Medicinal Chemistry, 2013, 21 24: Pages 7724-7734. DOI: 10.1016/j.bmc.2013.10.023

XEN445 Preparation Products And Raw materials

Raw materials

Preparation Products

XEN445 Suppliers

Global( 98)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29800 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5744 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32432 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2922 55
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
TargetMol Chemicals Inc. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Shanghai Boyle Chemical Co., Ltd. 55

View Lastest Price from XEN445 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
XEN445 pictures 2025-09-16 XEN445
1515856-92-4
 US $33.00-119.00 / mg 99.47% 10g TargetMol Chemicals Inc.
2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid pictures 2019-12-24 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid
1515856-92-4
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co
  • XEN445 pictures
  • XEN445
    1515856-92-4
  • US $33.00-119.00 / mg
  • 99.47%
  • TargetMol Chemicals Inc.

XEN445 Spectrum

XEN445(1515856-92-4)MS

1515856-92-4(XEN445)Related Search:

(+)-JQ-1 XE 991 dihydrochloride ADX-47273 (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one
2-[(3S)-3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acid CS-1251 XEN 445; XEN-445 XEN 445, >=98% XEN445 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid (S)-2-(3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid XEN445 XEN445 (S)-2-(3-(PYRIDIN-2-YLMETHOXY)PYRROLIDIN-1-YL)-5-(TRIFLUOROMETHYL)BENZOIC ACID. HCL 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid Benzoic acid, 2-[(3S)-3-(2-pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)- XEN445 >=98% (HPLC) Inhibitor,inhibit,XEN445 XEN445, 10 mM in DMSO XEN445 ，S7457 1515856-92-4 Inhibitors