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5-benzyl-1-oxa-5-azaspiro[2.4]heptane

5-benzyl-1-oxa-5-azaspiro[2.4]heptane Structure
5-benzyl-1-oxa-5-azaspiro[2.4]heptane structure
CAS No.
97266-84-7
Chemical Name:
5-benzyl-1-oxa-5-azaspiro[2.4]heptane
Synonyms
6-benzyl-1-oxa-6-azaspiro[2.4]heptane;5-benzyl-1-oxa-5-azaspiro[2.4]heptane;1-Oxa-5-azaspiro[2.4]heptane, 5-(phenylmethyl)-
CBNumber:
CB22718596
Molecular Formula:
C12H15NO
Molecular Weight:
189.25
MDL Number:
MFCD24384948
MOL File:
97266-84-7.mol
MSDS File:
SDS
Last updated:2026-05-28 00:07:10
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5-benzyl-1-oxa-5-azaspiro[2.4]heptane Properties

Boiling point 282.2±15.0 °C(Predicted)
Density 1.15±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka 8.62±0.20(Predicted)
Appearance Colorless to light yellow Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338

5-benzyl-1-oxa-5-azaspiro[2.4]heptane price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth XDA26684 5-benzyl-1-Oxa-5-azaspiro[2.4]heptane 97266-84-7 100mg $316 2026-06-05 Buy
Biosynth XDA26684 5-benzyl-1-Oxa-5-azaspiro[2.4]heptane 97266-84-7 1g $1003 2026-06-05 Buy
aablocks AA006D1Z 5-Benzyl-1-oxa-5-azaspiro[2.4]heptane 95% 97266-84-7 100mg $82 2026-05-28 Buy
aablocks AA006D1Z 5-Benzyl-1-oxa-5-azaspiro[2.4]heptane 95% 97266-84-7 250mg $147 2026-05-28 Buy
aablocks AA006D1Z 5-Benzyl-1-oxa-5-azaspiro[2.4]heptane 95% 97266-84-7 500mg $276 2026-05-28 Buy
Product number Packaging Price Buy
XDA26684 100mg $316 Buy
XDA26684 1g $1003 Buy
AA006D1Z 100mg $82 Buy
AA006D1Z 250mg $147 Buy
AA006D1Z 500mg $276 Buy

5-benzyl-1-oxa-5-azaspiro[2.4]heptane Chemical Properties, Uses, Production

Synthesis

1-Benzyl-3-pyrrolidinone

775-16-6

Trimethylsulfoxonium iodide

1774-47-6

5-benzyl-1-oxa-5-azaspiro[2.4]heptane

97266-84-7

To an ice bath cooled mixture of sodium hydride (60%, 0.59 g, 14.83 mmol) and trimethylsulfoxide iodide (2.76 g, 12.55 mmol) in dimethylsulfoxide (DMSO, 10 mL), the reaction mixture was kept at 10 °C. After stirring at 10 °C for 10 min, the mixture was brought to room temperature and stirring was continued for 1 hour. A solution of 1-benzyl-3-pyrrolidone (2 g, 11.41 mmol) in DMSO (10 mL) was slowly added via syringe over 10 min. The resulting reaction mixture was stirred at room temperature for 1.5 h, diluted with ether (Et2O) and the reaction was quenched by the addition of saturated aqueous ammonium chloride (NH4Cl). The organic and aqueous phases were separated and the aqueous phase was back-extracted with ether. The organic phases were combined, dried, filtered and concentrated under reduced pressure to give 5-benzyl-1-oxa-5-azaspiro[2.4]heptane (product, 2.10 g, 97% yield), which was used directly in the next step of the reaction. Mass spectrum (electrospray ionization, m/z): 190.1 [M+H]+.

References

[1] Patent: WO2016/42452, 2016, A1. Location in patent: Page/Page column 186
[2] Patent: WO2016/42453, 2016, A1. Location in patent: Page/Page column 91
[3] Patent: WO2018/178041, 2018, A1. Location in patent: Page/Page column 120
[4] Patent: WO2016/42451, 2016, A1. Location in patent: Page/Page column 97
[5] Synthesis (Germany), 2018, vol. 50, # 18, p. 3696 - 3707

5-benzyl-1-oxa-5-azaspiro[2.4]heptane Preparation Products And Raw materials

Raw materials

1-Benzyl-3-pyrrolidinone Trimethylsulfoxonium iodide Mineral oil Sodium hydride Dimethyl sulfoxide

Preparation Products

5-benzyl-1-oxa-5-azaspiro[2.4]heptane Suppliers

Global Suppliers ( 25)
Supplier Tel Email Country ProdList Advantage
ShangHai AmK Pharmaceutical Technology Co., Ltd. 微信 18019252918 18019252918 sale@amkchem.com China 14982 55
BePharm Ltd 400-685-9117 market@bepharm.com China 15081 60
BioPharmaMatrix,Inc. 0510-86010668 13395169561; sales@biopharmamatrix.com China 4977 55
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Aikon International Limited 025-66113011 19370895928 qzhang@aikonchem.com China 15390 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 021-4009004166/18616739031 18616739031 3007523370@qq.com China 40000 58
Hebei Beckman Biotechnology Co., Ltd. 15961617865 15961617865; 2245485247@qq.com China 4962 58
Birdo (Shanghai) Medical Technology Co., Ltd. 021-58099077-8041 18601625411 sales@birdotech.com China 9378 58
Taizhou Nanfeng Pharmaceutical Research Institute nanfengpharma@126.co 18616377689 nanfengpharma@126.com China 20008 58
Shanghai Haohong Pharmaceutical Co., Ltd. 400-8210725 4008210725 malulu@leyan.com China 54996 58
Supplier Advantage
ShangHai AmK Pharmaceutical Technology Co., Ltd. 55
BePharm Ltd 60
BioPharmaMatrix,Inc. 55
Amadis Chemical Company Limited 58
Aikon International Limited 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 58
Hebei Beckman Biotechnology Co., Ltd. 58
Birdo (Shanghai) Medical Technology Co., Ltd. 58
Taizhou Nanfeng Pharmaceutical Research Institute 58
Shanghai Haohong Pharmaceutical Co., Ltd. 58

View Latest Price from 5-benzyl-1-oxa-5-azaspiro[2.4]heptane manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-benzyl-1-oxa-5-azaspiro[2.4]heptane pictures 2026-08-25 5-benzyl-1-oxa-5-azaspiro[2.4]heptane
97266-84-7
 $2.00-6.00 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

5-benzyl-1-oxa-5-azaspiro[2.4]heptane Spectrum

5-benzyl-1-oxa-5-azaspiro[2.4]heptane(97266-84-7)1HNMR

97266-84-7 (5-benzyl-1-oxa-5-azaspiro[2.4]heptane) Related Search:

6-benzyl-1-oxa-6-azaspiro[2,5]octane 3-benzyl-7-oxa-3-aza-bicyclo[4.1.0]heptane 1-Oxa-5-azaspiro[2.4]heptane-5-carboxylic acid, 1,1-dimethylethyl ester 5-Cbz-1-oxa-5-azaspiro[2.4]heptane 1-Oxa-5-azaspiro[2.4]heptane
5-Benzyl-1-oxa-5-azaspiro[2.5]octane

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5-benzyl-1-oxa-5-azaspiro[2.4]heptane 6-benzyl-1-oxa-6-azaspiro[2.4]heptane 1-Oxa-5-azaspiro[2.4]heptane, 5-(phenylmethyl)- 97266-84-7