MaciMorelin Acetate
- CAS No.
- 945212-59-9
- Chemical Name:
- MaciMorelin Acetate
- Synonyms
- EP-1572 acetate;MaciMorelin Acetate;AEZS-130 acetate|||AEZS-130 acetate|||EP-1572 acetate;2-Amino-N-((R)-1-(((R)-1-formamido-2-(1H-indol-3-yl)ethyl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-2-methylpropanamide acetate
- CBNumber:
- CB22729293
- Molecular Formula:
- C28H34N6O5
- Molecular Weight:
- 534.60676
- MDL Number:
- MFCD28502054
- MOL File:
- 945212-59-9.mol
| Product description | Number | Pack Size | Price |
| Macimorelin acetate ≥98% (HPLC) | SML3680 | 5 mg | $102 |
| Macimorelin acetate ≥98% (HPLC) | SML3680 | 25 mg | $410 |
| storage temp. | -10 to -25°C |
|---|---|
| solubility | DMSO: 2mg/mL, clear |
| form | Solid |
| color | White to off-white |
| InChIKey | UJVDJAPJQWZRFR-DHIUTWEWSA-N |
| SMILES | [nH]1c2c(c(c1)C[C@@H](NC(=O)[C@H](NC(=O)C(N)(C)C)Cc3c4c([nH]c3)cccc4)NC=O)cccc2 |
| FDA UNII | AQZ1003RMG |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
MaciMorelin Acetate Chemical Properties,Uses,Production
Uses
Macimorelin (EP-1572) acetate, a GH secretagogue, is an orally active GHSR agonist. Macimorelin acetate stimulates GH release. Macimorelin acetate can be used in the research of adult growth hormone deficiency (AGHD), and Cancer anorexia-cachexia syndrome (CACS)[1][2][3].
Biological Activity
Macimorelin (AEZS-130; ARD-07; EP1572; UMV1843; Aib-DTrp-DgTrp-CHO) is an orally active peptido-mimetic growth hormone (GH) secretagogue (GHS) th at targets human and animal GHS-receptor (IC50 in nM = 10.2/ghrelin, 12.3/hexaghrelin, 15.6/macimorelin against ghrelin binding to human GHS-R) with potent and selective GH-releasing activity in vivo (GH level = 158.8 μg/L 15 min post 300 μg/kg s.c. in neonatal rats; 11.3 μg/L without treatment).
in vivo
Macimorelin (5 mg/kg, i.p. twice daily for 2 weeks) acetate decreased the number and duration of seizures in IHKA mouse model[2].
| Animal Model: | Intrahippocampal kainic acid (IHKA) mouse model[2] |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection (i.p.), twice daily for 2 weeks. |
| Result: | Significantly decreased the number and duration of seizures during the treatment period, but had no antiepileptogenic or disease-modifying effect. |
References
[1] Jose M Garcia, et al. Macimorelin as a Diagnostic Test for Adult GH Deficiency. J Clin Endocrinol Metab. 2018 Aug 1;103(8):3083-3093. DOI:10.1210/jc.2018-00665
[2] An Buckinx, et al. Translational potential of the ghrelin receptor agonist macimorelin for seizure suppression in pharmacoresistant epilepsy. Eur J Neurol. 2021 Sep;28(9):3100-3112. DOI:10.1111/ene.14992
[3] Ali SA, Garcia JM. Randomized clinical trial of the novel oral ghrelin mimetic macimorelin in the treatment of cancer cachexia: study design and preliminary results. Endocr Rev. 2013;34:
MaciMorelin Acetate Preparation Products And Raw materials
Raw materials
Preparation Products
MaciMorelin Acetate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19964 | 58 |
| Chongqing jooe co., ltd | +undefined86-15223382610 | info@jooe.com | China | 15976 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13913916777; | info@chemlin.com.cn | China | 15778 | 64 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9498 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | Eric@peptidego.com | China | 7408 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24963 | 58 |
| Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 0571-87213919 17306812703 | 3007955328@qq.com | China | 6979 | 58 |
| Aikon International Limited | 025-58859352 18921922613 | hywu@aikonchem.com | China | 10708 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
View Lastest Price from MaciMorelin Acetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-04 | Macimorelin acetate
945212-59-9
|
US $528.00-1358.00 / mg | 10g | TargetMol Chemicals Inc. |
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- Macimorelin acetate
945212-59-9
- US $528.00-1358.00 / mg
- TargetMol Chemicals Inc.
