CK-0157869
- CAS No.
- 388592-44-7
- Chemical Name:
- CK-0157869
- Synonyms
- CK 869;CK-869;CS-2870;CK-0157869;CK-869 ，S6954;CK-869, 10 mM in DMSO;CK-869; CK 869; CK869; CK-0157869; CK 0157869; CK0157869;2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone;2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)thiazolidin-4-one;CK869, Actin-related protein 2/3 (Arp2/3) complex inhibitor
- CBNumber:
- CB22755865
- Molecular Formula:
- C17H16BrNO3S
- Molecular Weight:
- 394.28
- MDL Number:
- MFCD01844129
- MOL File:
- 388592-44-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| CK-869 ≥98% (HPLC) | C9124 | 5mg | $129 |
| CK-869 ≥98% (HPLC) | C9124 | 25mg | $336.6 |
| CK-869 ≥98% | 15251 | 1mg | $30 |
| CK-869 ≥98% | 15251 | 5mg | $75 |
| CK-869 ≥98% | 15251 | 10mg | $119 |
| More product size | |||
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: soluble10mg/mL, clear |
| form | powder |
| color | white to light gray |
| InChI | 1S/C17H16BrNO3S/c1-21-13-6-7-14(15(9-13)22-2)19-16(20)10-23-17(19)11-4-3-5-12(18)8-11/h3-9,17H,10H2,1-2H3 |
| InChIKey | MVWNPZYLNLATCH-UHFFFAOYSA-N |
| SMILES | S1C(N(C(=O)C1)c3c(cc(cc3)OC)OC)c2cc(ccc2)Br |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H361-H372-H410 |
| Precautionary statements | P201-P264-P280-P301+P330+P331-P312 |
| Hazard Codes | N |
| Risk Statements | 50 |
| Safety Statements | 61 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
CK-0157869 price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C9124 | CK-869 ≥98% (HPLC) | 388592-44-7 | 5mg | $129 | 2026-04-30 | Buy |
| Sigma-Aldrich | C9124 | CK-869 ≥98% (HPLC) | 388592-44-7 | 25mg | $336.6 | 2026-04-30 | Buy |
| Cayman Chemical | 15251 | CK-869 ≥98% | 388592-44-7 | 1mg | $30 | 2026-04-30 | Buy |
| Cayman Chemical | 15251 | CK-869 ≥98% | 388592-44-7 | 5mg | $75 | 2026-04-30 | Buy |
| Cayman Chemical | 15251 | CK-869 ≥98% | 388592-44-7 | 10mg | $119 | 2026-04-30 | Buy |
CK-0157869 Chemical Properties,Uses,Production
Description
CK 869 is an inhibitor of actin polymerization via inhibition of the actin-related protein 2/3 (Arp2/3) complex, leading to reduced cell motility rate and rearrangement of F-actin in M-1 cells. It inhibits comet tail formation by L. monocytogenes with an IC50 value of 7 μM. It also impairs cell adhesion and cell spreading in MCF10A human breast epithelial cells.
Uses
CK-869 has been used as an Arp2/3 complex inhibitor:
- to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assembly
- to induce membrane blebbing in HT1080 fibrosarcoma cells
- to treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis
Uses
CK-869 binds to the Arp2/3 complex and inhibits nucleation. The Arp2/3 complex is involved with cell motility and F-actin reorganization in M-1 cells.
Biochem/physiol Actions
CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex.
References
[1] DARIA V ILATOVSKAYA. Arp2/3 complex inhibitors adversely affect actin cytoskeleton remodeling in the cultured murine kidney collecting duct M-1 cells.[J]. Cell and Tissue Research, 2013, 354 3: 783-792. DOI: 10.1007/s00441-013-1710-y
[2] B. J. NOLEN. Characterization of two classes of small molecule inhibitors of Arp2/3 complex[J]. Nature, 2009, 460 7258: 1031-1034. DOI: 10.1038/nature08231
[3] YVONNE BECKHAM. Arp2/3 inhibition induces amoeboid-like protrusions in MCF10A epithelial cells by reduced cytoskeletal-membrane coupling and focal adhesion assembly.[J]. PLoS ONE, 2014: e100943. DOI: 10.1371/journal.pone.0100943
CK-0157869 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Nanjing Dulai Biotechnology Co., Ltd. | 025-84699383-8003;025-846993838003-8003 18013301593;18013301590 | njduly@126.com | China | 3293 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4845 | 55 |
