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3-Chloro-1-(N,N-dimethyl)propylamine

3-Chloro-1-(N,N-dimethyl)propylamine structure

CAS No.: 109-54-6

Chemical Name:: 3-Chloro-1-(N,N-dimethyl)propylamine

Synonyms: 3-Chloro-N,N-diMethylpropan-1-aMine;3-Dimethylaminopropyl chloride;CAS:109-54-6;3-Chloro-1-(N;AURORA KA-7644;oro-1-(N,N-dimethyL;3-Chloro-1-(N,N-dime;N-dimethyl)propylamine;Benzydamine Impurity G;Zomitriptan Impurity 07

CBNumber:: CB2278089

Molecular Formula:: C5H12ClN

Molecular Weight:: 121.61

MDL Number:: MFCD00044496

MOL File:: 109-54-6.mol

Last updated:2025-07-24 18:13:42

Product description	Number	Pack Size	Price
3-Chloro-1-(N,N-dimethyl)propylamine	C364070	1g	$85
3-Chloro-N,N-dimethylpropan-1-amine	FC140337	10g	$100
3-Chloro-N,N-dimethylpropan-1-amine	FC140337	50g	$250
3-Chloro-N,N-dimethylpropan-1-amine	FC140337	100g	$400
3-Chloro-1-(N,N-dimethyl)propylamine,stabilizedwith0.5%oxalicacid	X8922	25mL	$61
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3-Chloro-1-(N,N-dimethyl)propylamine Properties

Melting point	168℃
Boiling point	140 °C
Density	0.929
refractive index	1.4320
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	Chloroform (Sparingly), Methanol (Slightly)
form	Liquid
pka	9.24±0.28(Predicted)
color	Colorless
Water Solubility	Slightly soluble in water.
Sensitive	Air Sensitive
Stability	Not stable in Solution
InChI	InChI=1S/C5H12ClN/c1-7(2)5-3-4-6/h3-5H2,1-2H3
InChIKey	NYYRRBOMNHUCLB-UHFFFAOYSA-N
SMILES	C(N(C)C)CCCl
LogP	1.244 (est)
CAS DataBase Reference	109-54-6(CAS DataBase Reference)
FDA UNII	G41F3T7H6Q

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P280a-P304+P340-P305+P351+P338-P405-P501a
RIDADR	2735
HazardClass	8
PackingGroup	Ⅲ

3-Chloro-1-(N,N-dimethyl)propylamine price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	C364070	3-Chloro-1-(N,N-dimethyl)propylamine	109-54-6	1g	$85	2021-12-16	Buy
Biosynth Carbosynth	FC140337	3-Chloro-N,N-dimethylpropan-1-amine	109-54-6	10g	$100	2021-12-16	Buy
Biosynth Carbosynth	FC140337	3-Chloro-N,N-dimethylpropan-1-amine	109-54-6	50g	$250	2021-12-16	Buy
Biosynth Carbosynth	FC140337	3-Chloro-N,N-dimethylpropan-1-amine	109-54-6	100g	$400	2021-12-16	Buy
AK Scientific	X8922	3-Chloro-1-(N,N-dimethyl)propylamine,stabilizedwith0.5%oxalicacid	109-54-6	25mL	$61	2021-12-16	Buy

Product number	Packaging	Price	Buy
C364070	1g	$85	Buy
FC140337	10g	$100	Buy
FC140337	50g	$250	Buy
FC140337	100g	$400	Buy
X8922	25mL	$61	Buy

3-Chloro-1-(N,N-dimethyl)propylamine Chemical Properties,Uses,Production

Chemical Properties

colorless liquid

Uses

3-Chloro-1-(N,N-dimethyl)propylamine is a genotoxic impurity in drug samples of rizatriptan benzoate. Also, it is the side chain of Chlorpromazine and Amitriptyline.

Synthesis

3-(DIMETHYLAMINO)PROPYL CHLORIDE HYDROCHLORIDE

5407-04-5

109-54-6

General procedure for the synthesis of 3-chloro-1-(N,N-dimethyl)propylamine from N,N-dimethylaminopropyl chloride hydrochloride: flake solid NaOH (42.1 g, 1052.5 mmol, 1.0 eq.) was dissolved in 142.1 g of water, a process which is exothermic, and an aqueous NaOH solution was obtained and then cooled down to 30 °C. In a 500 mL two-neck flask, HCl (104 g, 658 mmol, 1.0 eq.) and the above aqueous NaOH solution were added, the temperature was raised to 45 °C and the reaction was started with continuous stirring for 2 hours. After completion of the reaction, the reaction solution was cooled to room temperature (30 °C). The organic layer was separated and collected to give 74.93 g of wet 3-chloro-1-(N,N-dimethyl)propylamine (CPA). The water content of the product was determined to be 2.755% and the yield was 91.07% (as anhydrous CPA).

References

[1] Patent: CN105294496, 2016, A. Location in patent: Paragraph 0128; 0129; 0130; 0131; 0132
[2] Patent: CN106810523, 2017, A. Location in patent: Paragraph 0021
[3] Patent: WO2007/54105, 2007, A2. Location in patent: Page/Page column 20
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985, p. 2033 - 2038
[5] Patent: WO2009/133052, 2009, A1. Location in patent: Page/Page column 42

3-Chloro-1-(N,N-dimethyl)propylamine synthesis

Synthesis of 3-Chloro-1-(N,N-dimethyl)propylamine from 3-(DIMETHYLAMINO)PROPYL CHLORIDE HYDROCHLORIDE

3-Chloro-1-(N,N-dimethyl)propylamine Preparation Products And Raw materials

Raw materials

1-Bromopropane Allyl alcohol Dimethylamine Thionyl chloride 3-Dimethylamino-1-propanol

3-(DIMETHYLAMINO)PROPYL CHLORIDE HYDROCHLORIDE Water Sodium hydroxide

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Preparation Products

Citalopram Benzydamine hydrochloride Melitracen 4,4-Diethoxy-N,N-dimethyl-1-butanamine 3,3'-(2,7-DibroMo-9H-fluorene-9,9-diyl)bis(N,N-diMethylpropan- 1-aMine)

acepromazine 1-Propanamine, 3,3'-(phenylphosphinidene)bis[N,N-dimethyl- 3-[3-(Dimethylamino)propoxy]benzaldehyde N-[3-(2-AMINO-4-CHLOROPHENOXY)PROPYL]-N,N-DIMETHYLAMINE Depramine

[3-(3-CHLORO-9-OXA-1,2,10-TRIAZA-ANTHRACEN-10-YL)-PROPYL]-DIMETHYL-AMINE

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3-Chloro-1-(N,N-dimethyl)propylamine Suppliers

Global( 172)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	20342	58
Shandong Liteng Biotechnology Co. , Ltd.	+86-18663721413 +86-15552573001	rosy@litengpharm.com	China	3285	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21620	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29852	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88299272	info@edengenechem.com	China	2176	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58

Supplier	Advantage
Dideu Industries Group Limited	58
Shandong Liteng Biotechnology Co. , Ltd.	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Changzhou Ditong Chemical Co.,Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from 3-Chloro-1-(N,N-dimethyl)propylamine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2022-02-21	(3-chloropropyl)dimethylamine 109-54-6	US $0.00 / KG	1KG	98.6%	100 tons	Honest Joy Holdings Limited
2021-09-19	3-Chloro-1-(N,N-dimethyl)propylamine 109-54-6	US $1.10 / g	1g	99.00%	100 Tons min	Dideu Industries Group Limited
2019-07-06	3-Chloro-1-(N,N-dimethyl)propylamine 109-54-6	US $1.00 / kg	1kg	95%-99%	as request	Career Henan Chemical Co

(3-chloropropyl)dimethylamine
109-54-6
US $0.00 / KG
98.6%
Honest Joy Holdings Limited

3-Chloro-1-(N,N-dimethyl)propylamine
109-54-6
US $1.10 / g
99.00%
Dideu Industries Group Limited

3-Chloro-1-(N,N-dimethyl)propylamine
109-54-6
US $1.00 / kg
95%-99%
Career Henan Chemical Co

3-Chloro-1-(N,N-dimethyl)propylamine Spectrum

3-Chloro-1-(N,N-dimethyl)propylamine(109-54-6)¹HNMR

109-54-6(3-Chloro-1-(N,N-dimethyl)propylamine)Related Search:

N,N-Dimethylformamide Dacthal DIMETHYLTHEXYLSILYL CHLORIDE Sodium chloride CHLORODIMETHYLVINYLSILANE

Dimethyl sulfate ETHANE Dimethyl fumarate Choline chloride Polyvinyl chloride

tert-Butyldimethylsilyl chloride Isopropylamine Dimethyl ether Thionyl chloride Dimethyl phthalate

Ammonium chloride Dimethyl-N-propylamine Potassium chloride

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CAS:109-54-6 3-Chloro-1-(N,N-dimethyl)propanamine dimethylaminopropylchloride AURORA KA-7644 3-CHLORO-1-(N,N-DIMETHYL)PROPYLAMINE 3-chloropropyl(dimethyl)amine N-(3-Chloropropyl)-dimethylamine 1-(Dimethylamino)-3-chloropropane 1-Chloro-3-(N,N-dimethylamino)propane 3-Chloro-N,N-dimethyl-1-propanamine N,N-Dimethyl-3-chloropropane-1-amine 3-Dimethylaminopropyl chloride 3-Chloro-1-(N,N-diMethyl)propylaMine, 95+% N,N-Dimethyl-3-chloropropylamine 3-Chloro-1-(N,N-dime 3-Chloro-N,N-diMethylpropan-1-aMine oro-1-(N,N-dimethyL 1-Propanamine, 3-chloro-N,N-dimethyl- 3-Chloro-1-(N,N-dimethyl)propylamine ISO 9001：2015 REACH N-dimethyl)propylamine 3-Chloro-1-(N 3-Chloro-N,N-dimethylpropan Rutoside Trihydrate Impurity 15 Benzydamine Impurity G Zomitriptan Impurity 07 109-54-6 C5H12ClN Polyamines