Methyl 4-ketocyclohexanecarboxylate
- CAS No.
- 6297-22-9
- Chemical Name:
- Methyl 4-ketocyclohexanecarboxylate
- Synonyms
- 4-OXO-CYCLOHEXANECARBOXYLIC ACID METHYL ESTER;NSC 17321;4-carbomethoxycyclohexanone;4-(Methoxycarbonyl)cyclohexanone;Methyl 4-cyclohexanonecarboxylate;methyl 4-oxocyclohexancarboxylate;Methyl cyclohexanone-4-carboxylate;METHYL 4-KETOCYCLOHEXANECARBOXYLATE;4-CYCLOHEXANE CARBOXYLIC ACID METHYL ESTER;4-Oxocyclohexane-1-carboxylic acid methyl ester
- CBNumber:
- CB2282868
- Molecular Formula:
- C8H12O3
- Molecular Weight:
- 156.18
- MDL Number:
- MFCD00270324
- MOL File:
- 6297-22-9.mol
| Boiling point | 96-97 °C(Press: 8.0 Torr) |
|---|---|
| Density | 1.11g/ml |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | soluble in Chloroform, Methanol |
| form | Oil |
| color | Clear Colourless |
| InChI | InChI=1S/C8H12O3/c1-11-8(10)6-2-4-7(9)5-3-6/h6H,2-5H2,1H3 |
| InChIKey | BLYKGTCYDJZLFB-UHFFFAOYSA-N |
| SMILES | C1(C(OC)=O)CCC(=O)CC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H227-H315-H319-H335 |
| Precautionary statements | P305+P351+P338 |
| HS Code | 2918300090 |
Methyl 4-ketocyclohexanecarboxylate price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M315045 | Methyl4-Oxocyclohexanecarboxylate | 6297-22-9 | 2g | $165 | 2021-12-16 | Buy |
| Matrix Scientific | 114724 | Methyl 4-oxocyclohexanecarboxylate 97% | 6297-22-9 | 5g | $188 | 2021-12-16 | Buy |
| AK Scientific | W7499 | Methyl4-oxocyclohexanecarboxylate | 6297-22-9 | 5g | $49 | 2021-12-16 | Buy |
| Matrix Scientific | 114724 | Methyl 4-oxocyclohexanecarboxylate 97% | 6297-22-9 | 1g | $57 | 2021-12-16 | Buy |
| AK Scientific | W7499 | Methyl4-oxocyclohexanecarboxylate | 6297-22-9 | 10g | $81 | 2021-12-16 | Buy |
Methyl 4-ketocyclohexanecarboxylate Chemical Properties,Uses,Production
Uses
Methyl 4-Oxocyclohexanecarboxylate is an intermediate for preparation of imidazobenzazepine derivatives as dual H1/5-HT2A antagonists for treatment of sleep disorders.
Synthesis
The 4-hydroxy methyl ester (4.147 g; 26.21 mmol) was dissolved in 150 mL DCM, and pyridinium chlorochromate (PCC) (8.476 g; 39.32 mmol) was added. The reaction mixture was allowed to stir at room temperature overnight. The reaction mixture was diluted with ether and decanted. Solvents were removed, and the residue was purified by flash column chromatography using 25 percent EtOAc in a hexane mixture as eluent. The product Methyl 4-ketocyclohexanecarboxylate was obtained as a colorless oil.
References
[1] Journal of Organic Chemistry, 1991, vol. 56, # 5, p. 1758 - 1763
[2] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 23, p. 6309 - 6323
[3] Tetrahedron, 2006, vol. 62, # 42, p. 10000 - 10004
[4] Patent: US2010/9964, 2010, A1. Location in patent: Page/Page column 73
[5] Farmaco, Edizione Scientifica, 1984, vol. 39, # 12, p. 1024 - 1037
Methyl 4-ketocyclohexanecarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43339 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29800 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3969 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5744 | 58 |
View Lastest Price from Methyl 4-ketocyclohexanecarboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-03 | Methyl 4-ketocyclohexanecarboxylate
6297-22-9
|
US $1.00 / KG | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- Methyl 4-ketocyclohexanecarboxylate
6297-22-9
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
