troponin I type 3 (cardiac)
- CAS No.
- 339163-65-4
- Chemical Name:
- troponin I type 3 (cardiac)
- Synonyms
- cTnI;RCM1;CMH7;CMD2A;CMD1FF;RCM 1 NEW;troponin I3;RCM-1 ，S6898;RCM-1, 10 mM in DMSO;Troponin I ELISA Kit
- CBNumber:
- CB22914253
- Molecular Formula:
- C20H12N2OS4
- Molecular Weight:
- 424.58
- MDL Number:
- MFCD00742440
- MOL File:
- 339163-65-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Monoclonal Anti-TNNI3 antibody produced in mouse clone 1E7, purified immunoglobulin, buffered aqueous solution | WH0007137M4 | 100μg | $580 |
| Anti-TNNI3 antibody produced in goat affinity isolated antibody, buffered aqueous solution | SAB2502170 | 100μg | $628 |
| Monoclonal Anti-TNNI3 antibody produced in mouse clone 3A10A12, ascites fluid | SAB5300191 | 100μL | $503 |
| RCM-1 99 | AA01ENXX | 1mg | $48 |
| RCM-1 99% | AA01ENXX | 5mg | $58 |
| Boiling point | 632.8±55.0 °C(Predicted) |
|---|---|
| Density | 1.49±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO : 16.67 mg/mL (39.26 mM) |
| form | buffered aqueous solution |
| pka | -1.42±0.37(Predicted) |
| color | Off-white to gray |
| biological source | mouse |
| InChIKey | DCCYTKKDAZEVLY-UHFFFAOYSA-N |
| SMILES | [s]1c(ccc1)c2nc(c(c(c2)c4[s]ccc4)C#N)SCC(=O)c3[s]ccc3 |
| UNSPSC Code | 12352203 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
troponin I type 3 (cardiac) price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | WH0007137M4 | Monoclonal Anti-TNNI3 antibody produced in mouse clone 1E7, purified immunoglobulin, buffered aqueous solution | 339163-65-4 | 100μg | $580 | 2026-04-30 | Buy |
| Sigma-Aldrich | SAB2502170 | Anti-TNNI3 antibody produced in goat affinity isolated antibody, buffered aqueous solution | 339163-65-4 | 100μg | $628 | 2026-04-30 | Buy |
| Sigma-Aldrich | SAB5300191 | Monoclonal Anti-TNNI3 antibody produced in mouse clone 3A10A12, ascites fluid | 339163-65-4 | 100μL | $503 | 2023-01-07 | Buy |
| aablocks | AA01ENXX | RCM-1 99 | 339163-65-4 | 1mg | $48 | 2026-05-30 | Buy |
| aablocks | AA01ENXX | RCM-1 99% | 339163-65-4 | 5mg | $58 | 2026-05-30 | Buy |
troponin I type 3 (cardiac) Chemical Properties,Uses,Production
Uses
RCM-1 is a forkhead box M1 (FOXM1) inhibitor with an EC50 of 0.72 μM in U2OS cells. RCM-1 blocks the nuclear localization and increased the proteasomal degradation of FOXM1. RCM-1 can be used for asthma and other chronic airway diseases research[1].
General Description
Troponin I3, cardiac type (TNNI3), also known as cardiac troponin I (cTnI), is the inhibitory element of troponin. It possesses an inhibitory peptide (IP) domain and a switch peptide (SP) domain that is located N-terminal of the IP domain. The gene encoding TNNI3 is localized on human chromosome 19q13.42.
Biochem/physiol Actions
Troponin I3, cardiac type (TNNI3) or cardiac troponin I (cTnI) modulates the diastolic function of the heart. Low expression of TNNI3 is associated with cardiac diastolic dysfunction. Elevated expression of the protein indicates cardiac injury. TNNI3 is a biomarker for myocardial infarction and mutations in the gene encoding it have been linked to hypertrophic cardiomyopathy.
in vivo
RCM-1 reduces airway resistance, increased lung compliance, and decreased proinflammatory cytokine production in mice exposed to the house dust mite and interleukin-13 (IL-13), which triggers goblet cell metaplasia. In mice, RCM-1 reduces IL-13 and STAT6 signaling and prevented the expression of the STAT6 target genes Spdef and Foxa3[1].
storage
Store at -20°C
References
[1] Lifeng Sun, et al. The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. Sci Signal. 2017 Apr 18;10(475):eaai8583. DOI:10.1126/scisignal.aai8583
troponin I type 3 (cardiac) Preparation Products And Raw materials
Raw materials
Preparation Products
troponin I type 3 (cardiac) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Bide Pharmatech Ltd. | 400-400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89686 | 60 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9799 | 58 |
| Zhengzhou Huiju Chemical Co., Ltd. | 0371-55900031 18137872243 | 3927209986@qq.com | China | 9997 | 55 |
| Jiangsu aikang biomedical research and development co., LTD | 025-58859352 17714375163 | qzhang@aikonchem.com | China | 15525 | 58 |
