Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE

N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE

N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE Structure
N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE structure
CAS No.
188975-88-4
Chemical Name:
N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE
Synonyms
tert-Butyl 4-oxoazepane-1-carboxylate;CAS:188975-88-4;BOC-AZEPAN-4-ONE;1-Boc-4-oxoazepane;1-BOC-4-AZEPANONE;CBNuMber: CB2294582;N-BOC-HEXAHYDRO-1H-A;4-Boc-hexahydroazepinone;1-Boc-homopiperazin-4-one;N-Boc-4-perhydroazepinone
CBNumber:
CB2294582
Molecular Formula:
C11H19NO3
Molecular Weight:
213.27
MDL Number:
MFCD03788435
MOL File:
188975-88-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:13:43
Product description Number Pack Size Price
N-Boc-hexahydro-1H-azepin-4-one ≥95.0% (HPLC) 00833 1G $301
N-Boc-hexahydro-1H-azepin-4-one ≥95.0% (HPLC) 00833 5G $477
N-Boc-hexahydro-1H-azepin-4-one B3707 5G $214
N-Boc azepan-4-one 262833 1g $443
N-Boc azepan-4-one 262833 2g $598
More product size
Request For Quotation

N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE Properties

Boiling point 90-1000C/0.5mmHg
Density 1.072±0.06 g/cm3(Predicted)
refractive index n20/D 1.467
storage temp. 2-8°C
solubility Soluble in Chloroform, Dichloromethane, Ethanol and Ethyl Ether.
pka -1.50±0.20(Predicted)
form Liquid or Low Melting Solid
color Colorless to yellow
Sensitive Air Sensitive
InChI InChI=1S/C11H19NO3/c1-11(2,3)15-10(14)12-7-4-5-9(13)6-8-12/h4-8H2,1-3H3
InChIKey PMLBUVZPRKXMOX-UHFFFAOYSA-N
SMILES N1(C(OC(C)(C)C)=O)CCCC(=O)CC1
CAS DataBase Reference 188975-88-4(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P301+P312+P330-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22
Safety Statements  26-36/37/39
WGK Germany  WGK 3
HazardClass  IRRITANT
HS Code  29242990
Storage Class 10 - Combustible liquids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE price More Price(89)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 00833 N-Boc-hexahydro-1H-azepin-4-one ≥95.0% (HPLC) 188975-88-4 1G $301 2023-06-20 Buy
Sigma-Aldrich 00833 N-Boc-hexahydro-1H-azepin-4-one ≥95.0% (HPLC) 188975-88-4 5G $477 2023-06-20 Buy
TCI Chemical B3707 N-Boc-hexahydro-1H-azepin-4-one 188975-88-4 5G $214 2026-04-30 Buy
Usbiological 262833 N-Boc azepan-4-one 188975-88-4 1g $443 2026-06-03 Buy
Usbiological 262833 N-Boc azepan-4-one 188975-88-4 2g $598 2026-06-03 Buy
Product number Packaging Price Buy
00833 1G $301 Buy
00833 5G $477 Buy
B3707 5G $214 Buy
262833 1g $443 Buy
262833 2g $598 Buy

N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE Chemical Properties,Uses,Production

Chemical Properties

Yellow Oil

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. It is a fine chemical intermediate.

Synthesis

ETHYL 1-BOC-5-OXO-HEXAHYDRO-1H-AZEPINE-4-CARBOXYLATE

141642-82-2

N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE

188975-88-4

General procedure for the synthesis of tert-butyl 4-oxoazepane-1-carboxylate from ethyl 1-Boc-5-oxoazepane-4-carboxylate: to a solution of 1-tert-butyl 5-oxoazepane-1,4-dicarboxylate (Compound 82.1, 19.0 g, 66.6 mmol) of 1,4-dioxane (190 mL) was added sodium hydroxide (4.00 g) dropwise , 100 mmol) to a solution of water (100 mL). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the pH was adjusted to 4-5 with 3M aqueous hydrochloric acid solution and extracted with ethyl acetate (2 x 50 mL). The organic phases were combined, washed with brine (2 × 10 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using ethyl acetate/petroleum ether (1:3) as eluent to afford tert-butyl 4-oxoazepane-1-carboxylate (11 g, 77%) as a yellow oil.

References

[1] Patent: WO2004/35569, 2004, A2. Location in patent: Page/Page column 58
[2] Archiv der Pharmazie, 2013, vol. 346, # 3, p. 200 - 209
[3] Patent: WO2014/8197, 2014, A1. Location in patent: Page/Page column 151
[4] Patent: WO2015/95767, 2015, A1. Location in patent: Page/Page column 166
[5] Patent: WO2005/40169, 2005, A2. Location in patent: Page/Page column 84

N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE Preparation Products And Raw materials

Raw materials

4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Azepan-4-one ETHYL 1-BOC-5-OXO-HEXAHYDRO-1H-AZEPINE-4-CARBOXYLATE Di-tert-butyl dicarbonate 1-BENZYL-4-OXOAZEPANE HCL
4-Perhydroazepinone hydrochloride Dicarbonic acid, 1,1-dimethylethyl 1-methylethyl ester 1-BENZYL-HEXAHYDRO-4H-AZEPIN-4-ONE Sodium hydroxide 1,4-Dioxane

1of2

Preparation Products

ETHYL 1-BOC-5-OXO-HEXAHYDRO-1H-AZEPINE-4-CARBOXYLATE tert-butyl 4-(ethylamino)azepane-1-carboxylate tert-butyl 4-hydroxy-4-methylazepane-1-carboxylate tert-butyl 4-(benzylaMino)azepane-1-carboxylate

N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE Suppliers

Global( 299)Suppliers
Supplier Tel Email Country ProdList Advantage
Hefei Lbao Physical & Chemical Science Co.,Ltd 		+15184799099 lbaochemicals@gmail.com China 670 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Chembon Pharmaceutical Co., Ltd. 		+86-28-8425-2981 CHINA 722 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Speranza Chemical Co., Ltd. 		+86-86-075521030354 +8618688942810 sophieliu@speranzachem.com China 923 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29812 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10403 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Supplier Advantage
Hefei Lbao Physical & Chemical Science Co.,Ltd 		58
Capot Chemical Co.,Ltd. 		60
Chembon Pharmaceutical Co., Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Speranza Chemical Co., Ltd. 		55
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58

View Lastest Price from N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE pictures 2026-05-18 N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE
188975-88-4
 1kg 98% Hefei Lbao Physical & Chemical Science Co.,Ltd
N-Boc-hexahydro-1H-azepin-4-one pictures 2025-04-04 N-Boc-hexahydro-1H-azepin-4-one
188975-88-4
 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE pictures 2019-08-06 N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE
188975-88-4
 $8.80 1KG 97%-99% 100kg Career Henan Chemical Co

N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE Spectrum

N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE(188975-88-4)1HNMR

188975-88-4(N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE)Related Search:

ETHANE tert-butyl 5-(2-((Methylsulfonyl)oxy)ethyl)isoindoline-2-carboxylate tert-butyl 5-propionyl-1H-pyrrolo[3,2-b]pyridine-1-carboxylate 4-Oxo-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester N-BOC-5-FORMYLISOINDOLINE
tert-butyl 4-oxotetrahydropyrimidine-1(2H)-carboxylate N-BOC-5-(HYDROXYMETHYL)-ISOINDOLINE ETHYL 1-BOC-5-OXO-HEXAHYDRO-1H-AZEPINE-4-CARBOXYLATE ETHYL 1-BOC-4-OXO-3-AZEPANECARBOXYLATE N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE
Azepan-4-one 1-METHYLAZEPAN-4-ONE

1of3

N-Boc-4-perhydroazepinone 1H-Azepine-1-carboxylic acid TERT-BUTYL-HEXAHYDRO-4-OXO-1H-AZEPINE-1-CARBOXYLATE 1-Boc-homopiperazin-4-one N-Boc-hexahydro-1H-azepin-4-one ,96% tert-Butyl 4-oxoazepane-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-oxoazepane N-BOC-HEXAHYDRO-1H-A 1-(tert-Butoxycarbonyl)hexahydroazepin-4-one 1,1-DiMethylethyl 4-Oxohexahydro-1H-azepine-1-carboxylate Hexahydro-4-oxo-1H-Azepine-1-carboxylic Acid 1,1-DiMethylethyl Ester CBNuMber: CB2294582 N-Boc-4-oxo-azacycloheptane 1-Boc-4-oxoazepane tert-Butyl 4-oxoazepane-1-carboxyl Azepan-4-one, N-BOC protected 95% 1-(1,1-dimethylethoxycarbonyl)-1,2,3,5,6,7-hexahydroazepin-4-one N-BOC-PERHYDROAZEPIN-4-ONE N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE 1H-AZEPINE-1-CARBOXYLIC ACID, HEXAHYDRO-4-OXO-, 1,1-DIMETHYLETHYL ESTER Azepan-4-one, N-BOC protected 1-Boc-homopipoerazin-4-one 1-BOC-4-AZEPANONE 4-Boc-hexahydroazepinone N-Boc-hexahydro-1H-azepine-4-one 4-OXOAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER BOC-AZEPAN-4-ONE 1-Boc-hexahydro-1H-azepin-4-one 4-N-Boc-hexahydroazepinone 1-Boc-homopiperazin-4-one, tert-Butyl hexahydro-4-oxo-1H-azepine-1-carboxylate N-Boc-hexahydro-1H-azepin-4-one,98% ert-butyl4-oxoazepane-1-carboxylate CAS:188975-88-4 N-Boc-hexahydro-1H-azepin-4-one tert-Butyl 4-oxoazepane-1-carboxylate 188975-88-4 C11H19O3N pharmacetical Heterocycles series Building Blocks/Intermediates Heterocycles Miscellaneous Reagents