tert-butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate
- CAS No.
- 1029413-51-1
- Chemical Name:
- tert-butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate
- Synonyms
- 1-Boc-3-(4-amino-1-pyrazolyl)azetidine;tert-butyl 3-(4-aminopyrazol-1-yl)azetidine-1-carboxylate;tert-butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate;1-Azetidinecarboxylic acid, 3-(4-amino-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester
- CBNumber:
- CB23033362
- Molecular Formula:
- C11H18N4O2
- Molecular Weight:
- 238.29
- MDL Number:
- MFCD10687122
- MOL File:
- 1029413-51-1.mol
- MSDS File:
- SDS
| Boiling point | 399.5±32.0 °C(Predicted) |
|---|---|
| Density | 1.30±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| pka | 4.05±0.19(Predicted) |
| Appearance | Brown to reddish brown Liquid |
| InChI | InChI=1S/C11H18N4O2/c1-11(2,3)17-10(16)14-6-9(7-14)15-5-8(12)4-13-15/h4-5,9H,6-7,12H2,1-3H3 |
| InChIKey | JYDHOTMQNGXWGO-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CC(N2C=C(N)C=N2)C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS02 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H226 |
| Precautionary statements | P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235 |
tert-butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 52119 | 4-AMINO-1-(1-BOC-AZETIDIN-3-YL)-1H-PYRAZOLE 97% | 1029413-51-1 | 1G | $152 | 2026-04-30 | Buy |
| AstaTech | 52119 | 4-AMINO-1-(1-BOC-AZETIDIN-3-YL)-1H-PYRAZOLE 97% | 1029413-51-1 | 5G | $439 | 2026-04-30 | Buy |
| Biosynth | ERB41351 | 4-Amino-1-(1-Boc-azetidin-3-yl)-1H-pyrazole | 1029413-51-1 | 2.5g | $413 | 2026-06-04 | Buy |
| aablocks | AA0096SV | 4-Amino-1-(1-boc-azetidin-3-yl)-1H-pyrazole 95% | 1029413-51-1 | 100mg | $22 | 2026-05-28 | Buy |
| aablocks | AA0096SV | 4-Amino-1-(1-boc-azetidin-3-yl)-1H-pyrazole 95% | 1029413-51-1 | 250mg | $23 | 2026-05-28 | Buy |
tert-butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate Chemical Properties, Uses, Production
Uses
4-Amino-1-(1-boc-azetidin-3-yl)-1H-pyrazole is a pyrazolamine derivative that can be prepared by alkylation of nitropyrazole with alcohol and subsequent reduction.
Synthesis
1314987-79-5
1029413-51-1
The general procedure for the synthesis of tert-butyl 3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate from tert-butyl 3-(4-nitro-1H-pyrazol-1-yl)azetidine-1-carboxylate was carried out as follows: under an atmosphere of hydrogen gas (1 atmosphere), compound 54-b (1.33 g, 5 mmol) was dissolved in methanol (10 ml), 10% palladium carbon catalyst (0.1 g). The reaction mixture was stirred at 25 °C for 12 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford the crude product compound 65-b (940 mg, 79% yield). The product could be used in subsequent reactions without further purification. Liquid chromatography-mass spectrometry (electrospray ionization) analysis showed: m/z = 261 [M + Na]+.
References
[1] Patent: US2015/336982, 2015, A1. Location in patent: Paragraph 0406; 0407
[2] Tetrahedron Letters, 2008, vol. 49, # 18, p. 2996 - 2998
[3] Patent: EP2832734, 2015, A1. Location in patent: Paragraph 0521
tert-butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu J&B Technology Co., Ltd. | 028-61186694 15608078506 | 609128801@qq.com | China | 853 | 55 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 2000 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58859352 15955137747 | sales01@aikonchem.com | China | 16021 | 58 |
| Beijing Minruida Technology Co., Ltd. | 010-82387566 | sales@mreda.com.cn | China | 19323 | 58 |
| Chengdu Forest Science and Technology Development Co,. Ltd | 028-87925786 18010564218 | vendi@cdforestchem.com | China | 1992 | 58 |
| Chemwill Asia Co.,Ltd. | 86-21-51086038 | chemwill_asia@126.com | CHINA | 23861 | 58 |
| Ningbo Zeyu Chemical Technology Co., Ltd | 15066123231 | 2278736577@qq.com | China | 494 | 58 |
View Latest Price from tert-butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | tert-butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate
1029413-51-1
|
$1.00 | 1KG | 95% | 500kg | Career Henan Chemical Co |
-
- tert-butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate
1029413-51-1
- $1.00
- 95%
- Career Henan Chemical Co
