2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
![2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one Structure](CAS/20180702/GIF/635324-72-0.gif)
- CAS No.
- 635324-72-0
- Chemical Name:
- 2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
- Synonyms
- MDK24720;CTLA-4 - INHIBITO;CTLA-4 - INHIBITOR;CTLA-4 inhibitor 1;MDK 24720 (CTLA-4 inhibitor);B7-CD28 Interaction Inhibitor;B7/CD28 interaction inhibitor 1;B7/CD28 interaction inhibitor 1, 10 mM in DMSO;2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b;2-(4-fluorophenyl)-1,6-dihydro-6-methyl-4-[3-(trifluoromethyl)phenyl]dipyrazolo[3,4-b:3',4'-d]pyridin-3(2H)-one
- CBNumber:
- CB23048865
- Molecular Formula:
- C21H13F4N5O
- Molecular Weight:
- 427.35
- MDL Number:
- MFCD28127008
- MOL File:
- 635324-72-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| B7-CD28 Interaction Inhibitor ≥95% | 42398 | 1mg | $50 |
| B7-CD28 Interaction Inhibitor ≥95% | 42398 | 5mg | $224 |
| B7-CD28 Interaction Inhibitor ≥95% | 42398 | 10mg | $396 |
| B7-CD28 Interaction Inhibitor ≥95% | 42398 | 25mg | $743 |
| CTLA-4-inhibitor | AA00ELEK | 1mg | $82 |
| More product size | |||
2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one Properties
| Boiling point | 599.5±60.0 °C(Predicted) |
|---|---|
| Density | 1.54±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: Soluble: =10 mg/ml |
| form | Solid |
| pka | 5.76±0.20(Predicted) |
| color | Off-white to light yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 42398 | B7-CD28 Interaction Inhibitor ≥95% | 635324-72-0 | 1mg | $50 | 2026-04-30 | Buy |
| Cayman Chemical | 42398 | B7-CD28 Interaction Inhibitor ≥95% | 635324-72-0 | 5mg | $224 | 2026-04-30 | Buy |
| Cayman Chemical | 42398 | B7-CD28 Interaction Inhibitor ≥95% | 635324-72-0 | 10mg | $396 | 2026-04-30 | Buy |
| Cayman Chemical | 42398 | B7-CD28 Interaction Inhibitor ≥95% | 635324-72-0 | 25mg | $743 | 2026-04-30 | Buy |
| aablocks | AA00ELEK | CTLA-4-inhibitor | 635324-72-0 | 1mg | $82 | 2026-05-28 | Buy |
2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one Chemical Properties,Uses,Production
Uses
B7/CD28 interaction inhibitor 1 (copmound 6b) is a potent B7.1-CD28 interaction inhibitor with an IC50 of 50 nM[1].
Biological Activity
MDK 24720 (CTLA-4 inhibitor, copmound 6b) is a Cytotoxic T-Lymphocyte-Associated protein 4 (CTLA-4, CD152) inhibitor with IC50 of 50 nM for B7.1–CD28 inhibition.
in vitro
Bivalent CTLA4 homodimers bridge bivalent B7.1 homodimers to form an unusually stable signaling complex. Blocking B7/CD28 interactions with monoclonal antibodies or soluble receptors results in immunosuppression and enhanced allograft survival, while B7/CTLA-4 blockade results in enhanced antitumor immune responses. The interaction of co-stimulatory antigen molecules on T cells with B7 molecules on presenting cells plays an important role in the activation of naive T cells. Consequently, agents that disrupt these interactions should have applications in treatment of transplant rejection as well as autoimmune diseases.
target
| Target | Value |
| CD152 () | |
| B7.1–CD28 (Cell-free assay) | 50 nM |
References
[1] Green NJ, et al. Structure-activity studies of a series of dipyrazolo[3,4-b:3',4'-d]pyridin-3-ones binding to the immune regulatory protein B7.1. Bioorg Med Chem. 2003 Jul 3;11(13):2991-3013. DOI:10.1016/s0968-0896(03)00183-4
2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9539 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 9950 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 |
View Lastest Price from 2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | B7/CD28 interaction inhibitor 1
635324-72-0
|
$77.00-193.00 | 99.50% | 10g | TargetMol Chemicals Inc. |
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- B7/CD28 interaction inhibitor 1
635324-72-0
- $77.00-193.00
- 99.50%
- TargetMol Chemicals Inc.
