ALPHA2-MACROGLOBULIN
- CAS No.
- 95568-41-5
- Chemical Name:
- ALPHA2-MACROGLOBULIN
- Synonyms
- A2M;A2MD;CPAMD5;FWP007;S863-7;ALPHA2M;ALPHA2MG;A-2-M, HUMAN;ALPHA2 M, HUMAN;HUMAN ALPHA-2-M
- CBNumber:
- CB2306346
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD00130472
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| Hazard Codes | B |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| F | 10-21 |
| HS Code | 3504009000 |
ALPHA2-MACROGLOBULIN price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M6159 | α2-Macroglobulin from human plasma BioUltra, ≥98% (SDS-PAGE) | 1631137-21-7 | 1 mg | $314 | 2025-07-31 | Buy |
| Sigma-Aldrich | M6159 | α2-Macroglobulin from human plasma BioUltra, ≥98% (SDS-PAGE) | 1631137-21-7 | 5 mg | $1080 | 2025-07-31 | Buy |
| Sigma-Aldrich | M6159 | α2-Macroglobulin from human plasma BioUltra, ≥98% (SDS-PAGE) | 1631137-21-7 | 10 mg | $1870 | 2025-07-31 | Buy |
| Sigma-Aldrich | M6159 | α2-Macroglobulin from human plasma BioUltra, ≥98% (SDS-PAGE) | 1631137-21-7 | 1MG | $289 | 2023-06-20 | Buy |
| Sigma-Aldrich | M6159 | α2-Macroglobulin from human plasma BioUltra, ≥98% (SDS-PAGE) | 1631137-21-7 | 5MG | $989 | 2023-06-20 | Buy |
ALPHA2-MACROGLOBULIN Chemical Properties, Uses, Production
Uses
α2-Macroglobulin was used to study impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β which is an early biomarker for mild cognitive impairment preceding Alzheimer′s disease. It was also used in the control of the classical and the MBL pathway of complement activation.
Biochem/physiol Actions
α2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α2-M and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α2-M may contribute to tissue destruction during inflammation.
Description
Human Alpha-2 Macroglobulin is a tetrameric glycoprotein, produced in Human plasma and having a molecular mass of 725 kDa.
Source
Human Plasma
Background
Alpha-2 Macroglobulin is a serine proteases inhibitor, which inhibits coagulation by inactivating thrombin and Kallikrein, it inhibits fibrinolysis by inactivating plasmin and involved in transport. Alpha-2-Macroglobulin is a large plasma protein, which is produced by the liver, it’s composed of 4 identical subunits bound together by -S-S- bonds. A2M is able to inactivate many kinds of proteinases (including serine-, cysteine-, aspartic- and metalloproteinases). A2M has a 35 amino acid "bait" region in its structure. Proteinases bind and cleave the “bait” region become bound to A2M. Macrophage receptors recognize the proteinase-A2M complex and clear it from the system. A2M binds to and removes MMP-2 and MMP-9 (active forms of the gelatinase) from the circulation using scavenger receptors on the phagocytes. The levels of Alpha-2-macroglobulin are increased in nephrotic syndrome which is a condition where the kidneys start to leak out some of the smaller blood proteins. Due to its large size, A2-macroglobulin is retained in the bloodstream. Increased production of all proteins causes A2-macroglobulin concentration to increase. Chronic renal failure might lead to amyloid by alpha-2-macroglobulin. A2M is raised in cirrhosis, pregnancy and diabetes.
ALPHA2-MACROGLOBULIN Preparation Products And Raw materials
Raw materials
Preparation Products
ALPHA2-MACROGLOBULIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10305 | 58 |
| shlmai | 021-67680335 13052188602 | sale1@shlmai.net | China | 10000 | 58 |
| Absin Bioscience Inc. | 13761418683 | fengmj@univ-bio.com | China | 12045 | 58 |
| Supplier | Advantage |
|---|---|
| J & K SCIENTIFIC LTD. | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 69 |
| Career Henan Chemica Co | 58 |
| BOC Sciences | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 58 |
| shlmai | 58 |
| Absin Bioscience Inc. | 58 |
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