2-Chloro-5-fluoro-3-methoxypyridine
- CAS No.
- 1097264-89-5
- Chemical Name:
- 2-Chloro-5-fluoro-3-methoxypyridine
- Synonyms
- 2-Chloro-5-fluoro-3-methoxypyridine;Pyridine, 2-chloro-5-fluoro-3-methoxy-
- CBNumber:
- CB23064171
- Molecular Formula:
- C6H5ClFNO
- Molecular Weight:
- 161.56
- MDL Number:
- MFCD18256740
- MOL File:
- 1097264-89-5.mol
- MSDS File:
- SDS
2-Chloro-5-fluoro-3-methoxypyridine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 308006 | 2-Chloro-5-fluoro-3-methoxypyridine | 1097264-89-5 | 250.00mg | $73 | 2026-05-19 | Buy |
| Matrix Scientific | 308006 | 2-Chloro-5-fluoro-3-methoxypyridine | 1097264-89-5 | 1.00g | $287 | 2026-05-19 | Buy |
| Matrix Scientific | 308006 | 2-Chloro-5-fluoro-3-methoxypyridine | 1097264-89-5 | 5.00g | $885 | 2026-05-19 | Buy |
| aablocks | AA00HBIA | 2-Chloro-5-fluoro-3-methoxypyridine 97% | 1097264-89-5 | 50mg | $16 | 2026-05-28 | Buy |
| aablocks | AA00HBIA | 2-Chloro-5-fluoro-3-methoxypyridine 97% | 1097264-89-5 | 100mg | $21 | 2026-05-28 | Buy |
2-Chloro-5-fluoro-3-methoxypyridine Chemical Properties, Uses, Production
Synthesis
75711-01-2
1097264-89-5
General procedure for the synthesis of 2-chloro-5-fluoro-3-methoxypyridine from 2-chloro-3-methoxy-5-aminopyridine: To a suspension of 2-chloro-3-methoxy-5-aminopyridine (2.14 g, 13.50 mmol) in 4M aqueous HCl (10.12 mL, 40.50 mmol) under ice-bath cooling conditions was slowly added dropwise sodium nitrite ( 1.02 g, 14.84 mmol) dissolved in water (7 mL) was slowly added dropwise for 5 min. After the dropwise addition, the reaction mixture was stirred vigorously at 5 °C for 30 min. Subsequently, a solution of sodium tetrafluoroborate (2.67 g, 24.29 mmol) dissolved in water (17 mL) was added dropwise to the reaction mixture at 5 °C. Upon completion of the reaction, the resulting thick suspension was collected by filtration, washed sequentially with cold water and a small amount of cold ethanol, and then dried under reduced pressure at 55 °C for 8 hours. The resulting black solid was dissolved in xylene (25 mL) and refluxed for 1 hour. After completion of the reaction, the solvent was removed by evaporation under reduced pressure and the residue was dissolved in ethyl acetate and washed with saturated aqueous sodium bicarbonate. The organic phase was separated, dried with anhydrous sodium sulfate, filtered and the solvent was removed in vacuum. Finally, the black oily material obtained was purified by silica gel fast chromatography (Biotage SP4 25M, cyclohexane/ethyl acetate 95/5) to afford 2-chloro-5-fluoro-3-methoxypyridine (0.11 g, 0.69 mmol, 5% yield) as a light yellow solid.1H NMR (400 MHz, DMSO-d6) δ (ppm): 8.03 ( d, 1H), 7.70 (dd, 1H), 3.92 (s, 3H).
References
[1] Patent: US2009/22670, 2009, A1. Location in patent: Page/Page column 22-23
2-Chloro-5-fluoro-3-methoxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-5-fluoro-3-methoxypyridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 17714375163 | yftan@aikonchem.com | China | 16674 | 50 |
| Xi'an NewProChem Co.,Ltd. | 15332490153 | newprochem@126.com | China | 991 | 55 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Nanijing m&m biotechnology Co. ,Ltd. | 025-87782433 18021532344 | 1345332203@qq.com | China | 4226 | 58 |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 6746 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10452 | 58 |
| Huansheng Meisen Pharmaceutical Technology (Shandong) Co., Ltd | 0531-88762217 18301471076 | sales@acespharma.com | China | 3859 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
