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ChemicalBook >> CAS DataBase List >>2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline

2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline

2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline Structure
2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline structure
CAS No.
1609394-10-6
Chemical Name:
2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline
Synonyms
2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)benzenamine;Benzenamine, 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)-;EOS-61512;Deucravacitinib Impurity 8;BMS-986165 Related Compound 3;2-methoxybenzyl carbamimidothioate hydrochloride;2-Methoxy-3-(1-methyl-1,2,4-triazol-3-YL)aniline;2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline;2-Methoxy-3-(1-methy-1H-1 ,2,4-triazol-3-yl)aniline;2-methoxy-3- (1-methyl-1H-1,2,4-triazole-3-yl) aniline
CBNumber:
CB23122644
Molecular Formula:
C10H12N4O
Molecular Weight:
204.23
MDL Number:
MFCD30489435
MOL File:
1609394-10-6.mol
MSDS File:
SDS
Last updated:2026-05-28 00:17:45
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2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline Properties

Boiling point 437.6±55.0 °C(Predicted)
Density 1.29±0.1 g/cm3(Predicted)
storage temp. 2-8°C, protect from light
solubility DMSO (Slightly)
pka 3.45±0.10(Predicted)
form Solid
color Pale Orange to Brown
InChI InChI=1S/C10H12N4O/c1-14-6-12-10(13-14)7-4-3-5-8(11)9(7)15-2/h3-6H,11H2,1-2H3
InChIKey FIAZRZSVFOMYSD-UHFFFAOYSA-N
SMILES C1(N)=CC=CC(C2N=CN(C)N=2)=C1OC

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301+H311+H331
Precautionary statements  P261-P280-P301+P310-P311
REACH Registrations Active

2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth JPC39410 2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline 1609394-10-6 10g $389.4 2026-06-04 Buy
Biosynth JPC39410 2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline 1609394-10-6 25g $714 2026-06-04 Buy
Biosynth JPC39410 2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline 1609394-10-6 50g $908.5 2026-06-04 Buy
Biosynth JPC39410 2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline 1609394-10-6 100g $1298 2026-06-04 Buy
Matrix Scientific 238895 2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline 1609394-10-6 1.00g $2600 2026-05-18 Buy
Product number Packaging Price Buy
JPC39410 10g $389.4 Buy
JPC39410 25g $714 Buy
JPC39410 50g $908.5 Buy
JPC39410 100g $1298 Buy
238895 1.00g $2600 Buy

2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline Chemical Properties, Uses, Production

Chemical Properties

white solid

Uses

2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline is used in the preparation of pyridazines which is a heterodimeric cytokines modulators for treatment of diseases.

Synthesis

To a high pressure reactor flushed with nitrogen were charged methanol (8.0 kg/kg) and Compound 6 (1.0 kg). With careful exclusion of oxygen, sodium bicarbonate (0.6 kg/kg, 2.0 equiv.) and Pd/C (10% loading, 50 % wet, 0.02 kg/kg)  were added. The reactor was pressurized with hydrogen (41-46 psi), and the reaction mixture was aged at 20 °C for 6 h then heated to 45 °C and aged till reaction reached completion. The reactor was flushed with nitrogen, and the reaction crude was filtered to remove Pd/C. Methanol (5 kg/kg) was used to aid the transfer. The combined filtrates were distilled under vacuum until total volume became approximately 2.5 L/kg. Water (10 kg/kg) was added, and the crude was distilled under vacuum until total volume became approximately 2.5 L/kg. The crude was heated to 70 °C. Brine (25 wt%, 9.0 kg/kg) was added, and the resulting crude was agitated for 6 h at 70 °C. After cooling down to 0 °C, the crude was further aged for 6 h. Product was isolated by filtration. The cake was washed with brine (pre-cooled to 0 °C, 25 wt%, 2.0 kg/kg), and dried under vacuum at 45 °C.  2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline was isolated in 99 AP and 88% yield.
synthesis of 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline

2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline synthesis

1609394-08-2
1609394-10-6
Synthesis of 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline from 3-(2-methoxy-3-nitrophenyl)-1-methyl-1H-1,2,4-triazole

2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

Deucravacitinib

2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline Suppliers

Global Suppliers ( 194)
Supplier Tel Email Country ProdList Advantage
Beijing Zhongshuo Pharmaceutical Technology Development Co., Ltd 13801189771 13801208576 maggie@chinazhongshuo.com China 88 65
Jinan XuanDe Chemical Co., Ltd. 0531-88803958 19862127196 zhangxu@shiningpharm.com China 202 58
Sichuan Kaike Pharmaceutical Technology Co., Ltd 13981731671 checo@checopharma.com China 450 58
Heading （Nanjing）Pharmtechnologies Co., Ltd. 025-58467899-832 13382406280 liucheng@headingpharm.com China 45 58
Hangzhou Chemtrue Bio-Tech Co.,Ltd. 19967494293 sales@chemtrue-bio.com China 303 58
Nanjing Tianyuexing Bio-tech Co.,Ltd. 吴经理15305186370 15305186370 david@chicopharm.com China 716 58
PharmaBlock Sciences (Nanjing),Inc. 025-86918202 4000255188 sales@pharmablock.com China 5000 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 28-83379370 13880556291 tcy@tcypharm.com China 509 57
Shanghai Hope Chem Co., Ltd.， +21-18501659228 18501659228 info@hope-chem.com China 538 55
Supplier Advantage
Beijing Zhongshuo Pharmaceutical Technology Development Co., Ltd 65
Jinan XuanDe Chemical Co., Ltd. 58
Sichuan Kaike Pharmaceutical Technology Co., Ltd 58
Heading （Nanjing）Pharmtechnologies Co., Ltd. 58
Hangzhou Chemtrue Bio-Tech Co.,Ltd. 58
Nanjing Tianyuexing Bio-tech Co.,Ltd. 58
PharmaBlock Sciences (Nanjing),Inc. 55
Energy Chemical 61
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 57
Shanghai Hope Chem Co., Ltd.， 55

View Latest Price from 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-methoxybenzyl carbamimidothioate hydrochloride pictures 2026-09-02 2-methoxybenzyl carbamimidothioate hydrochloride
1609394-10-6
 20kg 99% 20 tons Qingdao RENAS Polymer Material Co., Ltd.
2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline pictures 2026-08-08 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline
1609394-10-6
 1kg 99.0% 20 tons Hangzhou ICH Biofarm Co., Ltd
2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline pictures 2026-06-30 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline
1609394-10-6
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd

2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline Spectrum

2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline(1609394-10-6)1HNMR2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline(1609394-10-6)1HNMR

1609394-10-6 (2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline) Related Search:

2-methoxy-3-(1-(methyl-d3)-1H-1,2,4-triazol-3-yl)aniline Benzenamine, 2-(methoxy-d3)-3-(1-methyl-1H-1,2,4-triazol-3-yl)- 3-(2-methoxy-3-nitrophenyl)-1-methyl-1H-1,2,4-triazole Benzenamine, 5-(1,3-dimethyl-1H-1,2,4-triazol-5-yl)-2-methoxy- 3-(3-Bromo-2-methoxyphenyl)-1-methyl-1H-1,2,4-triazole
Benzenamine, 2-methoxy-5-(1H-1,2,4-triazol-5-yl)-

1of2

2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline EOS-61512 BMS-986165 Related Compound 3 Benzenamine, 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)- 2-Methoxy-3-(1-methyl-1,2,4-triazol-3-YL)aniline 2-Methoxy-3-(1-methyl-1H-[1,2,4]triazol-3-yl)-phenylamine 2-methoxybenzyl carbamimidothioate hydrochloride 2-Methoxy-3-(1-methy-1H-1 ,2,4-triazol-3-yl)aniline 2-methoxy-3- (1-methyl-1H-1,2,4-triazole-3-yl) aniline Deucravacitinib Impurity 8 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline(1609394-10-6)/98%/30g 2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)benzenamine 1609394-10-6