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5-BROMO-2-METHOXY-NICOTINIC ACID

5-BROMO-2-METHOXY-NICOTINIC ACID structure

CAS No.: 54916-66-4

Chemical Name:: 5-BROMO-2-METHOXY-NICOTINIC ACID

Synonyms: Zinc04352712;5-Bromo-2-methoxynic;5-Bromo-2-methoxynicotinicAci;2-Methoxy-5-bromoinicotinic acid;5-BROMO-2-METHOXY-NICOTINIC ACID;5-Bromo-2-methoxynicotinic acid 98%;5-Bromo-2-methoxypyridine-3-carboxylic acid;5-BROMO-2-METHOXY-3-PYRIDINECARBOXYLIC ACID;3-Pyridinecarboxylic acid, 5-bromo-2-methoxy-;5-BROMO-2-METHOXY-NICOTINIC ACID ISO 9001：2015 REACH

CBNumber:: CB2313227

Molecular Formula:: C7H6BrNO3

Molecular Weight:: 232.03

MDL Number:: MFCD06656771

MOL File:: 54916-66-4.mol

MSDS File:: SDS

Last updated:2025-08-06 17:05:54

Product description	Number	Pack Size	Price
5-Bromo-2-methoxypyridine-3-carboxylic acid 97%	725250	1g	$103
5-Bromo-2-methoxynicotinicacid	B696755	100mg	$45
5-Bromo-2-methoxynicotinicacid	B696755	500mg	$65
5-Bromo-2-methoxynicotinicacid	B696755	1g	$75
5-Bromo-2-methoxy-nicotinic acid 99%	023784	5g	$45
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5-BROMO-2-METHOXY-NICOTINIC ACID Properties

Melting point	156-158
Boiling point	324.8±42.0 °C(Predicted)
Density	1.713
storage temp.	Inert atmosphere,Room Temperature
pka	2.97±0.10(Predicted)
form	solid
Appearance	White to off-white Solid
InChI	InChI=1S/C7H6BrNO3/c1-12-6-5(7(10)11)2-4(8)3-9-6/h2-3H,1H3,(H,10,11)
InChIKey	SJLXURQPRRMPIV-UHFFFAOYSA-N
SMILES	C1(OC)=NC=C(Br)C=C1C(O)=O
CAS DataBase Reference	54916-66-4(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Safety Statements

24/25

WGK Germany

nwg

Hazard Note

Irritant/Keep Cold

HazardClass

IRRITANT

HS Code

29333990

NFPA 704

	0
2		0

5-BROMO-2-METHOXY-NICOTINIC ACID price More Price(41)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	725250	5-Bromo-2-methoxypyridine-3-carboxylic acid 97%	54916-66-4	1g	$103	2023-06-20	Buy
TRC	B696755	5-Bromo-2-methoxynicotinicacid	54916-66-4	100mg	$45	2021-12-16	Buy
TRC	B696755	5-Bromo-2-methoxynicotinicacid	54916-66-4	500mg	$65	2021-12-16	Buy
TRC	B696755	5-Bromo-2-methoxynicotinicacid	54916-66-4	1g	$75	2021-12-16	Buy
Matrix Scientific	023784	5-Bromo-2-methoxy-nicotinic acid 99%	54916-66-4	5g	$45	2021-12-16	Buy

Product number	Packaging	Price	Buy
725250	1g	$103	Buy
B696755	100mg	$45	Buy
B696755	500mg	$65	Buy
B696755	1g	$75	Buy
023784	5g	$45	Buy

5-BROMO-2-METHOXY-NICOTINIC ACID Chemical Properties,Uses,Production

Uses

5-Bromo-2-methoxy-nicotinic acid is used as an intermediate in pharmaceutical synthesis and can be employed to prepare RXFP1 receptor agonists. Its synthetic products can selectively activate the RXFP1 receptor for the treatment of heart failure, with an EC50 value of approximately 6.3nM.

Synthesis

16498-81-0

54916-66-4

General procedure for the synthesis of 5-bromo-2-methoxynicotinic acid from 2-methoxynicotinic acid: 2-methoxynicotinic acid (20 g, 130.60 mmol) was dissolved in H2O (1500 mL) at room temperature, followed by slow addition of Br2 (20 mL, 375.45 mmol). The reaction mixture was stirred continuously at room temperature overnight. Upon completion of the reaction, the solid product was collected by filtration and washed thoroughly with deionized water and finally dried to afford 5-bromo-2-methoxynicotinic acid (25 g, 82% yield). The structure of the product was confirmed by 1H-NMR (DMSO-d6, 400 MHz) and mass spectrometry (MS): 1H-NMR δ 13.33 (br s, 1H), 8.47 (d, J = 2.4 Hz, 1H), 8.21 (d, J = 2.4 Hz, 1H), 3.90 (s, 3H); MS (M + H)+ m/z: 232/234.

References

[1] Patent: WO2013/33971, 2013, A1. Location in patent: Page/Page column 144
[2] Patent: US2014/213571, 2014, A1. Location in patent: Paragraph 0572

5-BROMO-2-METHOXY-NICOTINIC ACID Preparation Products And Raw materials

Raw materials

2-Methoxynicotinic acid

Preparation Products

5-BROMO-2-METHOXY-NICOTINIC ACID Suppliers

Global( 190)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16516	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29799	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58

Supplier	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Capot Chemical Co.,Ltd.	60
Shenzhen Nexconn Pharmatechs Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58
Accela ChemBio Inc.	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58

View Lastest Price from 5-BROMO-2-METHOXY-NICOTINIC ACID manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-13	5-Bromo-2-methoxynicotinic acid 54916-66-4	US $2.00-6.00 / kg	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2021-10-26	5-BROMO-2-METHOXY-NICOTINIC ACID 54916-66-4	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2020-01-01	5-BROMO-2-METHOXY-NICOTINIC ACID 54916-66-4	US $7.00 / KG	1KG	99%	100KG	Career Henan Chemical Co

5-Bromo-2-methoxynicotinic acid
54916-66-4
US $2.00-6.00 / kg
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

5-BROMO-2-METHOXY-NICOTINIC ACID
54916-66-4
US $1.10 / g
99.00%
Dideu Industries Group Limited

5-BROMO-2-METHOXY-NICOTINIC ACID
54916-66-4
US $7.00 / KG
99%
Career Henan Chemical Co

5-BROMO-2-METHOXY-NICOTINIC ACID Spectrum

5-BROMO-2-METHOXY-NICOTINIC ACID(54916-66-4)¹HNMR

54916-66-4(5-BROMO-2-METHOXY-NICOTINIC ACID)Related Search:

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5-BROMO-2-METHOXY-3-PYRIDINECARBOXYLIC ACID 5-BROMO-2-METHOXY-NICOTINIC ACID 5-Bromo-2-methoxypyridine-3-carboxylic acid 5-Bromo-2-methoxynicotinic acid 98% Zinc04352712 5-Bromo-2-methoxypyridine-3-carboxylic acid, 5-Bromo-3-carboxy-2-methoxypyridine 3-Pyridinecarboxylic acid, 5-bromo-2-methoxy- 5-BROMO-2-METHOXY-NICOTINIC ACID ISO 9001：2015 REACH 5-Bromo-2-methoxynic 2-Methoxy-5-bromoinicotinic acid 5-Bromo-2-methoxynicotinicAci 54916-66-4 Carboxylic Acids blocks Bromides Carboxes Pyridines