SP 141
- CAS No.
- 1253491-42-7
- Chemical Name:
- SP 141
- Synonyms
- SP 141;SP 141;SP141;;SP-141, 10 mM in DMSO;MDM2 Inhibitor, SP-141;6-Methoxy-1-(1-naphthyl)-9H-β-carboline;6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole;6-methoxy-1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indole;9H-Pyrido[3,4-b]indole, 6-methoxy-1-(1-naphthalenyl)-;pancreatic,SP-141,inhibit,Inhibitor,cancer,MDM-2/p53,breast,degradation,auto-ubiquitination,SP141
- CBNumber:
- CB23146385
- Molecular Formula:
- C22H16N2O
- Molecular Weight:
- 324.38
- MDL Number:
- MFCD29059920
- MOL File:
- 1253491-42-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 571.2±45.0 °C(Predicted) |
|---|---|
| Density | 1.284±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≤100mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide |
| form | crystalline solid |
| pka | 15.04±0.40(Predicted) |
| color | White to yellow |
| InChI | 1S/C22H16N2O/c1-25-15-9-10-20-19(13-15)18-11-12-23-21(22(18)24-20)17-8-4-6-14-5-2-3-7-16(14)17/h2-13,24H,1H3 |
| InChIKey | AABFWJDLCCDJJN-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(NC2=C3C=CN=C2C4=CC=CC5=C4C=CC=C5)C3=C1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
SP 141 price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17003 | SP-141 ≥98% | 1253491-42-7 | 1mg | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 17003 | SP-141 ≥98% | 1253491-42-7 | 5mg | $130 | 2026-04-30 | Buy |
| Cayman Chemical | 17003 | SP-141 ≥98% | 1253491-42-7 | 10mg | $213 | 2026-04-30 | Buy |
| Cayman Chemical | 17003 | SP-141 ≥98% | 1253491-42-7 | 50mg | $934 | 2026-04-30 | Buy |
| Usbiological | 256718 | SP 141 Asreported | 1253491-42-7 | 10mg | $460 | 2026-06-03 | Buy |
SP 141 Chemical Properties, Uses, Production
Description
Mouse double minute 2 protein (MDM2) is an E3 ubiquitin-protein ligase that binds and ubiquitinates the tumor suppressor p53, leading to its degradation by the proteasome. SP 141 is a cell-permeable inhibitor of MDM2 (Ki = 28 nM). Binding of MDM2 by SP 141 promotes its auto-ubiquitination and proteasomal degradation. SP 141 induces cell cycle arrest and apoptosis in breast and pancreatic cancer cell lines and inhibits xenograft tumor growth in vivo. This compound has a short half-life in plasma and wide tissue distribution in tumor-bearing nude mice.
Uses
SP 141 induces cell cycle arrest and apoptosis in breast and pancreatic cancer cell lines, inhibiting xenograft tumor growth in vivo.
in vivo
SP-141 (40 mg/kg; administered by i.p. injection; 5 d/wk for about three weeks) suppresses pancreatic tumor growth in both xenograft and orthotopic mouse models[1].
| Animal Model: | Nude mice bearing Panc-1 xenograft tumors[1] |
| Dosage: | 40 mg/kg |
| Administration: | Administered by i.p. injection; 5 d/wk for about three weeks |
| Result: | Significantly suppressed the growth of pancreatic xenograft tumors. On Day 18, the tumor volume in the treated group was reduced by 75% compared with that in the control group. There were no significant differences in the body weight compared with the control group. |
storage
Store at +4°C
References
[1]. vassilev lt, vu bt, graves b, et al. in vivo activation of the p53 pathway by small-molecule antagonists of mdm2. science. 2004 feb 6;303(5659):844-8.
[2]. wang w, qin jj, voruganti s, et al. the pyrido[b]indole mdm2 inhibitor sp-141 exerts potent therapeutic effects in breast cancer models. nat commun. 2014 oct 1;5:5086.
[3]. wang w, qin jj, voruganti s, et al. identification of a new class of mdm2 inhibitor that inhibits growth of orthotopic pancreatic tumors in mice. gastroenterology. 2014 oct;147(4):893-902.e2.
[4]. nag s, qin jj, voruganti s, et al. development and validation of a rapid hplc method for quantitation of sp-141, a novel pyrido[b]indole anticancer agent, and an initial pharmacokinetic study in mice. biomed chromatogr. 2015 may;29(5):654-63.
SP 141 Preparation Products And Raw materials
Raw materials
Preparation Products
SP 141 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 981 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Changyan Chem & Tech Co., Ltd. | 021-20242659 18930833303 | sales@changyanchem.cn | China | 4998 | 55 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9783 | 55 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Taizhou Crene Biotechnology Co. Ltd. | +86-0576-88813233 +86-13396860566 | sales@pharm-intermediates.com | China | 1976 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
