6-Bromoquinoline
- CAS No.
- 5332-25-2
- Chemical Name:
- 6-Bromoquinoline
- Synonyms
- 6-Bromoquinoline,97%;NSC 3996;6-BromoquinoL;6-Br-quinoline;6-bromo-quinolin;6-BROMOQUINOLINE;6-BROMOOQUINOLINE;TIMTEC-BB SBB001559;Quinoline, 6-bromo-;6-Bromoquinoline>
- CBNumber:
- CB2314673
- Molecular Formula:
- C9H6BrN
- Molecular Weight:
- 208.05
- MDL Number:
- MFCD00024023
- MOL File:
- 5332-25-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 6-Bromoquinoline 97% | 697893 | 1g | $32.6 |
| 6-Bromoquinoline 97% | 697893 | 5g | $113 |
| 6-Bromoquinoline >95.0%(GC) | B2015 | 1g | $22 |
| 6-Bromoquinoline >95.0%(GC) | B2015 | 5g | $63 |
| 6-Bromoquinoline | B2867-01 | 1g | $333 |
| More product size | |||
| Melting point | 19°C |
|---|---|
| Boiling point | 116 °C / 6mmHg |
| Density | 1.538 g/mL at 25 °C |
| refractive index | n20/D 1.663 |
| Flash point | 19 °C |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Soluble in acetone, acetonitrile, dichloromethane, ethyl acetate and THF. |
| pka | 4.18±0.10(Predicted) |
| form | Oil |
| color | Light yellow to brown |
| InChI | InChI=1S/C9H6BrN/c10-8-3-4-9-7(6-8)2-1-5-11-9/h1-6H |
| InChIKey | IFIHYLCUKYCKRH-UHFFFAOYSA-N |
| SMILES | N1C2C(=CC(Br)=CC=2)C=CC=1 |
| CAS DataBase Reference | 5332-25-2(CAS DataBase Reference) |
| FDA UNII | KS7HD5UJ94 |
| NIST Chemistry Reference | 6-Bromo quinoline(5332-25-2) |
| EPA Substance Registry System | Quinoline, 6-bromo- (5332-25-2) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-41-37/38-22-20/21/22 | |||||||||
| Safety Statements | 26-37/39-39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29334900 | |||||||||
| NFPA 704 |
|
6-Bromoquinoline price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 697893 | 6-Bromoquinoline 97% | 5332-25-2 | 1g | $32.6 | 2022-05-15 | Buy |
| Sigma-Aldrich | 697893 | 6-Bromoquinoline 97% | 5332-25-2 | 5g | $113 | 2022-05-15 | Buy |
| TCI Chemical | B2015 | 6-Bromoquinoline >95.0%(GC) | 5332-25-2 | 1g | $22 | 2025-07-31 | Buy |
| TCI Chemical | B2015 | 6-Bromoquinoline >95.0%(GC) | 5332-25-2 | 5g | $63 | 2025-07-31 | Buy |
| Usbiological | B2867-01 | 6-Bromoquinoline | 5332-25-2 | 1g | $333 | 2021-12-16 | Buy |
6-Bromoquinoline Chemical Properties,Uses,Production
Bromoquinoline
There are seven positional isomers of bromoquinoline and their main properties are listed below:
Application and synthetic method
3-bromo-quinoline is reacted with mixed acid for generating 3-bromo-5-nitro-quinoline, which heats together with potassium permanganate for being oxidation into 5-bromo-2, 3-pyridine dicarboxylic acid.
6-bromo-quinoline is heated together with nitric acid to generate 6-bromo-8-nitro quinolone with further reaction with potassium permanganate for being oxidized to 2, 3-pyridinedicarboxylic acid.
2-bromo-quinolien can be synthesized through the reaction between 2-hydroxy quinoline and phosphorus pentabromide.
Quinoline perbromide is heated at 180 °C for generating 3-bromo-quinoline.
From the heating between 4-hydroxy quinoline and phosphorus pentabromide, or from the diazotization reaction via 4-aminoquinoline to generate 4-bromo-quinoline;
5-bromo-quinoline is synthesize by the heating reaction between m-bromo-aniline, glycerol, m-bromo nitrobenzene and concentrated sulfuric acid, or from the diazotization reaction of 5-aminoquinoline.
6-bromo-quinoline can be synthesized from the heating of bromoaniline, glycerol, concentrated sulfuric acid, and p-bromo-nitrobenzene.
7-bromo-quinoline can be synthesized from the diazotization reaction of 7-aminoquinoline.
8-bromo-quinoline can be synthesized from the heating reaction of o-bromo-aniline, glycerol, concentrated sulfuric acid and o-bromo nitrobenzene.
application: as organic synthesis reagents.
The above information is edited by the Chemicalbook of Dai Xiongfeng.
Chemical Properties
Thick Oil
Uses
6-Bromoquinoline is used as fine chemical and pharmaceutical intermediate, used as the coupling reagent.
Synthesis
4-Bromobenzenamine (25 g, 145.32 mmol, 1.00 equiv), sodium 3-nitrobenzenesulfonate (55.5 g, 246.64 mmol, 1.70 equiv), propane-1,2,3-triol (50.8 g, 551.63 mmol, 3.80 equiv), and sulfuric acid (170 mL, 70%) were placed into a 500-mL round-bottom flask. The resulting solution was stirred overnight at 140° C. The pH value of the solution was adjusted to with 10% aqueous sodium hydroxide. The resulting solution was extracted with 5*150 mL of ethyl acetate. The organic layers were combined and dried over anhydrous sodium sulfate, and concentrated in vacuo. The residue was purified by silica gel column chromatography eluting with ethyl acetate/petroleum ether (1:50). This resulted in 17.2 g (42%) of 6-bromoquinoline as yellow oil.
References
[1] Indian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry, 2016, vol. 55A, # 8, p. 919 - 928
[2] Patent: US2012/277224, 2012, A1. Location in patent: Page/Page column 90
[3] Dyes and Pigments, 2013, vol. 99, # 1, p. 240 - 249
[4] Patent: WO2006/2981, 2006, A1. Location in patent: Page/Page column 96
[5] Chemische Berichte, 1882, vol. 15, p. 559
6-Bromoquinoline Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| China Synchem Technology Co.,Ltd. | +86-0552-4929304 +86-18055277008 | wangxuhui1985@126.com | China | 65 | 55 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8757 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 8554 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5244 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20130 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21603 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29840 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
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View Lastest Price from 6-Bromoquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-07 | 6-Bromoquinoline
5332-25-2
|
US $32.00-266.00 / g | 25g | 0.97 | 25kg | Shanghai UCHEM Inc. | |
 |
2026-01-05 | 6-Bromoquinoline
5332-25-2
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-11-18 | 6-Bromoquinoline
5332-25-2
|
US $1.10 / g | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited |
-
- 6-Bromoquinoline
5332-25-2
- US $32.00-266.00 / g
- 0.97
- Shanghai UCHEM Inc.
-
- 6-Bromoquinoline
5332-25-2
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 6-Bromoquinoline
5332-25-2
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
