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ChemicalBook >> CAS DataBase List >>ER-000444793

ER-000444793

ER-000444793 Structure
ER-000444793 structure
CAS No.
792957-74-5
Chemical Name:
ER-000444793
Synonyms
ER-000444793;ER-000444793 (ER000444793);ER-000444793, 10 mM in DMSO;N-(2-benzylphenyl)-2-oxy-1,2-dihydroquinoline-4-carboxamide;N-(2-Benzylphenyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide;4-Quinolinecarboxamide, 1,2-dihydro-2-oxo-N-[2-(phenylmethyl)phenyl]-;Mitochondrial Metabolism,Inhibitor,ER-000444793,inhibit,ER000444793,ER 000444793
CBNumber:
CB23155149
Molecular Formula:
C23H18N2O2
Molecular Weight:
354.4
MDL Number:
MFCD31544321
MOL File:
792957-74-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-14 16:49:18
Product description Number Pack Size Price
ER-000444793 SGB95774 5mg $840.55
ER-000444793 SGB95774 10mg $1344.8
ER-000444793 SGB95774 25mg $2192.75
ER-000444793 SGB95774 50mg $3508
ER-000444793 98.0% CS-7582 1mg $95
Request For Quotation

ER-000444793 Properties

storage temp. Store at -20°C
solubility DMSO : ≥ 100 mg/mL (282.17 mM)
form Solid
color Off-white to light yellow

ER-000444793 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth SGB95774 ER-000444793 792957-74-5 5mg $840.55 2026-06-05 Buy
Biosynth SGB95774 ER-000444793 792957-74-5 10mg $1344.8 2026-06-05 Buy
Biosynth SGB95774 ER-000444793 792957-74-5 25mg $2192.75 2026-06-05 Buy
Biosynth SGB95774 ER-000444793 792957-74-5 50mg $3508 2026-06-05 Buy
ChemScene CS-7582 ER-000444793 98.0% 792957-74-5 1mg $95 2026-06-04 Buy
Product number Packaging Price Buy
SGB95774 5mg $840.55 Buy
SGB95774 10mg $1344.8 Buy
SGB95774 25mg $2192.75 Buy
SGB95774 50mg $3508 Buy
CS-7582 1mg $95 Buy

ER-000444793 Chemical Properties,Uses,Production

Uses

ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening. ER-000444793 inhibits mPTP with an IC50 of 2.8 μM.

Biological Activity

ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening. It inhibits mPTP with IC50 of 2.8 μM.

in vitro

ER-000444793 is a small molecule, non-toxic mPTP inhibitor with a mechanism of action independent of CypD inhibition. It potently and dose-dependently inhibits Ca 2+ -induced mPT. It binds CypD, a CsA/CypD homogenous time-resolved fluorescence (HTRF) assay is used to study compound binding. Both CsA and SfA dose-dependently decrease HTRF signal, suggesting displacement of labelled CsA from rhCypD protein (CsA IC 50 =23 nM and SfA IC 50 = 5 nM). In contrast, ER-000444793 has no effect up to a concentration of 50 μM, indicating lack of displacement of labelled -CsA from rhCypD protein. Together, these data suggest the mechanism of it in delaying mPT is independent of CypD functional inhibition.

target

IC50: 2.8 μM (mPTP)

References

[1] Briston T, et al. Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria. Sci Rep. 2016 Nov 25;6:37798. DOI:10.1038/srep37798

ER-000444793 Preparation Products And Raw materials

Raw materials

Preparation Products

ER-000444793 Suppliers

Global( 45)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
BOC Sciences 		16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
Aladdin Scientific 		tp@aladdinsci.com United States 57473 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4773 55
Shanghai YuanYe Biotechnology Co., Ltd. 13636370518 shyysw007@163.com China 89667 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9740 55
Shanghai Biopharmaleader Co., Ltd. +86 18721201413 sales@biopharmaleader.com China 1712 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
BOC Sciences 		58
InvivoChem 		58
Aladdin Scientific 		58
Shanghai Boyle Chemical Co., Ltd. 55
MedChemexpress LLC 58
Guangzhou Isun Pharmaceutical Co., Ltd 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Shanghai Biopharmaleader Co., Ltd. 58

View Lastest Price from ER-000444793 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ER-000444793 pictures 2026-07-14 ER-000444793
792957-74-5
 $70.00-247.00 99.55% 10g TargetMol Chemicals Inc.
  • ER-000444793 pictures
  • ER-000444793
    792957-74-5
  • $70.00-247.00
  • 99.55%
  • TargetMol Chemicals Inc.

ER-000444793 Spectrum

ER-000444793(792957-74-5)1HNMR

792957-74-5(ER-000444793)Related Search:

2(1H)-Quinolinone, 6-(aminomethyl)-3-methyl-, hydrochloride (1:1) (3Z)-3-(phenylmethylidene)-2,3-dihydro-1H-indol-2-one 2(1H)-Quinolinone, 3-(aminomethyl)-6-methyl- 3-Quinolinecarboxaldehyde, 6-(1,1-dimethylethyl)-1,2-dihydro-2-oxo- 3-cyclohexylidene-1,3-dihydro-indol-2-one
6-AMino-3-Methyl-2(1H)-quinolinone

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ER-000444793 ER-000444793 (ER000444793) 4-Quinolinecarboxamide, 1,2-dihydro-2-oxo-N-[2-(phenylmethyl)phenyl]- N-(2-Benzylphenyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide Mitochondrial Metabolism,Inhibitor,ER-000444793,inhibit,ER000444793,ER 000444793 ER-000444793, 10 mM in DMSO N-(2-benzylphenyl)-2-oxy-1,2-dihydroquinoline-4-carboxamide 792957-74-5