AQX-1125 Free
- CAS No.
- 782487-29-0
- Chemical Name:
- AQX-1125 Free
- Synonyms
- AQX-1125 Free;Rosiptor acetate;AQX 1125 acetate (AQX-1125 acetate
- CBNumber:
- CB23159864
- Molecular Formula:
- C22H39NO4
- Molecular Weight:
- 381.56
- MDL Number:
- MOL File:
- 782487-29-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| FDA UNII | F6X6NZ9D95 |
|---|
AQX-1125 Free Chemical Properties, Uses, Production
Uses
Rosiptor (AQX-1125) acetate is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor acetate (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro[1][2].
in vivo
Rosiptor acetate (3-30 mg/kg; p.o.; daily for 3 days) significantly reduces the total number of BAL leukocytes in NSC-125066-challenged mice and reduces MPO activity[2].
Rosiptor acetate (10 mg/kg; p.o.) has the Cmax value of 0.830 μM and the t1/2 value of 5.2 hours. AQX-1125 also exhibits >80% oral bioavailability[1].
References
[1] Stenton GR, et al. Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic characterization in vivo. Br J Pharmacol. 2013 Mar;168(6):1506-18. DOI:10.1111/bph.12039
[2] Cross J, et al. AQX-1125, small molecule SHIP1 activator inhibits NSC-125066-induced pulmonary fibrosis. Br J Pharmacol. 2017 Sep;174(18):3045-3057. DOI:10.1111/bph.13934
AQX-1125 Free Preparation Products And Raw materials
Raw materials
Preparation Products
AQX-1125 Free Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shanghai Biopharmaleader Co., Ltd. | +86 18721201413 | sales@biopharmaleader.com | China | 1711 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shaanxi Didu Pharmaceutical Co., Ltd. | 029-81124775 17791530730 | 1079@dideu.com | China | 10000 | 58 |
| Hu Bei Jiutian Bio-medical Technology CO.,Ltd | 027-88013699 17354350817 | Ryan@jiutian-bio.com | China | 5927 | 58 |
