Pomalidomide-d5
- CAS No.
- 1377838-49-7
- Chemical Name:
- Pomalidomide-d5
- Synonyms
- Pomalidomide-d5;4-Amino-2-(2,6-dioxopiperidin-3-yl-3,4,4,5,5-d5)isoindoline-1,3-dione
- CBNumber:
- CB23163577
- Molecular Formula:
- C13H11N3O4
- Molecular Weight:
- 273.25
- MDL Number:
- MFCD34564597
- MOL File:
- 1377838-49-7.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361 |
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 |
Pomalidomide-d5 price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25358 | Pomalidomide-d5 ≥99% deuterated forms (d1-d5) | 1377838-49-7 | 500μg | $364 | 2024-03-01 | Buy |
| Cayman Chemical | 25358 | Pomalidomide-d5 ≥99% deuterated forms (d1-d5) | 1377838-49-7 | 1mg | $691 | 2024-03-01 | Buy |
| TRC | P688203 | Pomalidomide-d5 | 1377838-49-7 | 1mg | $200 | 2021-12-16 | Buy |
| TRC | P688203 | Pomalidomide-d5 | 1377838-49-7 | 10mg | $1585 | 2021-12-16 | Buy |
| AK Scientific | 5113EG | 4-Amino-2-(3,4,4,5,5-pentadeuterio-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione | 1377838-49-7 | 1mg | $866 | 2021-12-16 | Buy |
Pomalidomide-d5 Chemical Properties,Uses,Production
Description
Pomalidomide-d5 is intended for use as an internal standard for the quantification of pomalidomide by GC- or LC-MS. Pomalidomide is an analog of thalidomide that inhibits the E3 ligase protein cereblon (CRBN) with an IC50 value of approximately 3 μM for the human recombinant CRBN-DNA damage binding protein-1 (CRBN-DDB1) complex. It inhibits autoubiquitination of CRBN in HEK293T cells expressing CRBN but not those expressing a thalidomide-binding defective CRBN mutation. It inhibits proliferation of U266 myeloma cells when used at concentrations ranging from 0.1 to 10 μM. Pomalidomide also has antiangiogenic and immunomodulatory effects against myeloma cells, modulating cell adhesion, decreasing production of key pro-survival cytokines, including TNF-α, and triggering the activation of caspase-8. Pomalidomide (3 mg/kg per day), in combination with dexamethasone, reduces tumor growth in a H929 R10-1 lenalidomide-resistant mouse xenograft model. Formulations containing pomalidomide have been used in the treatment of multiple myeloma.
Uses
Pomalidomide-d5 is the labeled analogue of Pomalidomide (P688200), a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
IC 50
Cereblon
Pomalidomide-d5 Preparation Products And Raw materials
Raw materials
Preparation Products
Pomalidomide-d5 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 13675144456 | sean.lv@synzest.com | China | 11438 | 58 |
| Changzhou Xianglong Pharmaceutical Technology Co., LTD | 18661161657 | yaoxiangqiu2021@163.com | China | 9999 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TLC Pharmaceutical Standards Ltd. | 18012923235; 18012923235 | chinasales04@tlcstandards.com.cn | China | 7407 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 27736 | 58 |
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