N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide
- CAS No.
- 796-42-9
- Chemical Name:
- N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide
- Synonyms
- AS8351;NSC51355;NSC-51355;NSC 51355;AS8351, 10 mM in DMSO;AS8351;AS 8351;NSC51355;NSC 51355;NSC-51355;N'-[(2-Hydroxy-1-naphthyl)methylene]isonicotinohydrazide;N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide;NSC-51355,NSC 51355,Histone Demethylase,AS8351,inhibit,Inhibitor;N-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]pyridine-4-carbohydrazide
- CBNumber:
- CB23166598
- Molecular Formula:
- C17H13N3O2
- Molecular Weight:
- 291.3
- MDL Number:
- MFCD00033110
- MOL File:
- 796-42-9.mol
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| solubility | Soluble in DMSO (45 mg/ml); ethanol (10 mg/ml with warming) |
| form | solid |
| color | Yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| NFPA 704 |
|
N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1692 | AS8351 ≥98% (HPLC) | 796-42-9 | 5MG | $108 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1692 | AS8351 ≥98% (HPLC) | 796-42-9 | 25MG | $424 | 2023-01-07 | Buy |
| Cayman Chemical | 20811 | AS-8351 ≥98% | 796-42-9 | 5mg | $56 | 2024-03-01 | Buy |
| Cayman Chemical | 20811 | AS-8351 ≥98% | 796-42-9 | 10mg | $106 | 2024-03-01 | Buy |
| Cayman Chemical | 20811 | AS-8351 ≥98% | 796-42-9 | 25mg | $221 | 2024-03-01 | Buy |
N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide Chemical Properties,Uses,Production
Description
AS-8351 is a histone demethylase inhibitor. It has been used in combination with CHIR99021 , A 83-01 , BIX01294 , SC-1 , Y-27632 (Item No. 10005583), OAC2 , SU 16f , and JNJ-10198409 to induce reprogramming of human fetal lung fibroblasts into functional cardiomyocytes.
Uses
AS 8351 is used in the conversion of human fibroblasts into functional cardiomyocytes, which provides a promising source for regenerative therapy.
in vitro
in a previous study, in order to identify indispensable factors for human fibroblasts, the authors removed combined compounds one by one and treated cells with the remaining compounds. results showed that the number of beating clusters was significantly reduced by removal of seven compounds including as8351. moreover, these seven compounds inlcuding as8351 were sufficient and necessary to induce cardiac reprogramming efficiently. the authors then investigated the role of the reprogramming compound of as8351 and the results showed that as8351 and its functional analogs could affect epigenetic modifications by competing with α- ketoglutarate for chelating iron/fe(ii) in some epigenetic enzymes, including the jmjc-domain-containing histone demethylases that require α-kg and iron as co-factors. in addition, the authors abrogated each of the 22 genes in the jmjc-kdm family by small hairpin rnas and found that only with kdm5b knockdown, or using a kdm5b inhibitor, pbit could phenocopy as8351 in generating cicms, indicating that it might be a target of as8351 [1].
IC 50
KDM5
References
1) Cao et al. (2016), Conversion of human fibroblasts into functional cardiomyocytes by small molecules; Science, 352 1216
N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29807 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12197 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 |
View Lastest Price from N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-01 | AS8351
796-42-9
|
US $43.00-118.00 / mg | 99.72% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-12-25 | N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide
796-42-9
|
US $1.00 / g | 1g | 99.99% | 200kg | Career Henan Chemical Co |
-
- AS8351
796-42-9
- US $43.00-118.00 / mg
- 99.72%
- TargetMol Chemicals Inc.
-
- N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide
796-42-9
- US $1.00 / g
- 99.99%
- Career Henan Chemical Co