2-Amino-6-methylpyrazine
- CAS No.
- 5521-56-2
- Chemical Name:
- 2-Amino-6-methylpyrazine
- Synonyms
- 6-METHYLPYRAZIN-2-AMINE;6-Methyl-2-pyrazinamine;2-AMINO-6-METHYLPYRAZINE;2-AMINE-6-METHYLPYRAZINE;6-METHYLPYRAZIN-2-YLAMINE;2-Pyrazinamine, 6-methyl-;2-Amino-6-methylpyrazine97%;2-Amino-6-methylpyrazine 97%;6-Methylpyrazin-2-amine, 2-Amino-6-methyl-1,4-diazine
- CBNumber:
- CB2319683
- Molecular Formula:
- C5H7N3
- Molecular Weight:
- 109.13
- MDL Number:
- MFCD08235193
- MOL File:
- 5521-56-2.mol
| Product description | Number | Pack Size | Price |
| 2-Amino-6-methylpyrazine >97.0%(GC) | A2992 | 200mg | $33 |
| 2-Amino-6-methylpyrazine >97.0%(GC) | A2992 | 1g | $93 |
| 6-Methylpyrazin-2-amine | M218790 | 100mg | $75 |
| 2-Amino-6-methylpyrazine 97% | OR6126 | 250mg | $37 |
| 2-Amino-6-methylpyrazine,≥97%(GC) ≥97%(GC) | 43584 | 1G | $105.15 |
| More product size | |||
| Melting point | 122.0 to 126.0 °C |
|---|---|
| Boiling point | 246.0±35.0 °C(Predicted) |
| Density | 1.155±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| form | Solid |
| pka | 3.52±0.10(Predicted) |
| color | White to Yellow to Orange |
| InChI | InChI=1S/C5H7N3/c1-4-2-7-3-5(6)8-4/h2-3H,1H3,(H2,6,8) |
| InChIKey | UAOOJJPSCLNTOP-UHFFFAOYSA-N |
| SMILES | C1(N)=NC(C)=CN=C1 |
| CAS DataBase Reference | 5521-56-2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
2-Amino-6-methylpyrazine price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2992 | 2-Amino-6-methylpyrazine >97.0%(GC) | 5521-56-2 | 200mg | $33 | 2025-07-31 | Buy |
| TCI Chemical | A2992 | 2-Amino-6-methylpyrazine >97.0%(GC) | 5521-56-2 | 1g | $93 | 2025-07-31 | Buy |
| TRC | M218790 | 6-Methylpyrazin-2-amine | 5521-56-2 | 100mg | $75 | 2021-12-16 | Buy |
| Apolloscientific | OR6126 | 2-Amino-6-methylpyrazine 97% | 5521-56-2 | 250mg | $37 | 2021-12-16 | Buy |
| Chem-Impex | 43584 | 2-Amino-6-methylpyrazine,≥97%(GC) ≥97%(GC) | 5521-56-2 | 1G | $105.15 | 2021-12-16 | Buy |
2-Amino-6-methylpyrazine Chemical Properties,Uses,Production
Uses
6-Methylpyrazin-2-amine is used in the preparation of heterocyclic amides containing pyridyl sulfones as TYK-2 signaling inhibitors useful in treatment of inflammatory and autoimmune diseases.
Synthesis
930798-25-7
5521-56-2
1. A solution of diethyl malonate (2.1 mmol) in THF (60 ml) was mixed with a solution of 2,6-dichloropyrazine (20 g) in THF (40 ml) at 60 °C. 2. The mixture was heated to reflux for 18 hrs and subsequently cooled to room temperature and 2M hydrochloric acid (100 ml) was added. 3. The two layers of the reaction solution were separated and the THF layer was partially concentrated under vacuum to give a solution containing diethyl 2-(6-chloropyrazin-2-yl)malonate. 4. The above solution was cooled to 10 °C, 2 M sodium hydroxide (328 ml) was added and stirred for 24 hours. 5. The mixture was washed with methyl isobutyl ketone (MIBK, 200 ml) and the organic layer was discarded. 6. The aqueous layer containing 2-(6-chloropyrazin-2-yl)malonic acid was added to 6M hydrochloric acid (135 ml) and the reaction temperature was controlled at 20-25°C to promote the decarboxylation reaction. 7. 6-Chloropyrazin-2-ylacetic acid was partially precipitated and extracted into MIBK (130 ml) for separation, dried with MgSO4, filtered and evaporated to give a yellow solid. 8. The crude product (22.4 g) was crystallized from methyl tert-butyl ether (MTBE) to give pure 6-chloropyrazin-2-ylacetic acid in 67% yield (15.4 g) based on 2,6-dichloropyrazine. 9. 6-Chloropyrazin-2-ylacetic acid (20.0 g) was reacted with ammonia (120 ml) in a sealed vessel at 180 °C (35 bar) for 8 hours. 10. The reaction mixture was cooled to 20 °C, water (40 ml) was added and the ammonia was removed by vacuum concentration. 11. The product was extracted into ethyl acetate, the solution was treated with charcoal and subsequently dried over MgSO4, filtered and evaporated to give 6-methyl-2-pyrazinamine as a light green solid (9.0 g, 71% yield based on 6-chloropyrazin-2-ylacetic acid). Analytical Data: - Diethyl 2-(6-chloropyrazin-2-yl)malonate: MS (EI+ve) 273/275 (M+H); 1H NMR (CDCl3): δ 8.7 (1H, s), 8.5 (1H, s), 4.9 (1H, s), 4.2 (4H, q), 1.2 (6H, t). - 6-Chloropyrazin-2-ylacetic acid: MS (EI+ve) 173/175 (M+H); 1H NMR (CDCl3): δ 8.55 (1H, s), 8.50 (1H, s); 3.9 (2H, s). - 6-Methyl-2-pyrazinamine: MS (GC/MS): 100% RT 2.0 min, M+H = 110; 1H NMR (CDCl3): δ 7.8 (1H, s), 7.8 (1H, s), 4.4 (2H, bs), 2.4 (3H, s). Mpt: 124-125°C.
References
[1] Patent: WO2007/35153, 2007, A1. Location in patent: Page/Page column 2; 4-5
[2] Journal of Heterocyclic Chemistry, 2008, vol. 45, # 5, p. 1451 - 1456
[3] Patent: WO2007/35154, 2007, A1. Location in patent: Page/Page column 28-29
2-Amino-6-methylpyrazine Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29833 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3987 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
View Lastest Price from 2-Amino-6-methylpyrazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 2-Amino-6-methylpyrazine
5521-56-2
|
US $1.00 / KG | 1KG | 98% | 150KG | Career Henan Chemical Co |
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- 2-Amino-6-methylpyrazine
5521-56-2
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
