METHYL N-4-BOC-N-1-CBZ-2-PIPERAZINECARBOXYLATE
- CAS No.
- 126937-42-6
- Chemical Name:
- METHYL N-4-BOC-N-1-CBZ-2-PIPERAZINECARBOXYLATE
- Synonyms
- Methyl 4-Boc-1-Cbz-2-piperazinecarboxylate;METHYL N-4-BOC-N-1-CBZ-2-PIPERAZINECARBOXYLATE;METHYL 4-N-BOC-1-N-CBZ-2-PIPERAZINE CARBOXYLATE;4-N-BOC-1-N-CBZ-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER;Methyl (±)-1-benzyloxycarbonyl-4-Boc-piperazine-2-carboxylate;O1-benzyl O4-tert-butyl O2-methyl piperazine-1,2,4-tricarboxylate;1-(Benzyloxycarbonyl)-2-(methoxycarbonyl)-4-(tert-butoxycarbonyl)-piperazine;Methyl 1-(benzyloxycarbonyl)-4-(tert-butyloxycarbonyl)piperazine-2-carboxylate;1,2,4-Piperazinetricarboxylic acid, 4-(1,1-dimethylethyl) 2-methyl 1-(phenylmethyl) ester;(2R)-piperazine-1,2,4-tricarboxylic acid O4-tert-butyl ester O2-methyl ester O1-(phenylmethyl) ester
- CBNumber:
- CB2326564
- Molecular Formula:
- C19H26N2O6
- Molecular Weight:
- 378.42
- MDL Number:
- MFCD03426296
- MOL File:
- 126937-42-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-Benzyl4-tert-Butyl2-MethylPiperazine-1,2,4-tricarboxylate | B130270 | 50mg | $45 |
| 1-Benzyl4-tert-Butyl2-MethylPiperazine-1,2,4-tricarboxylate | B130270 | 500mg | $130 |
| METHYL N-4-BOC-N-1-CBZ-2-PIPERAZINECARBOXYLATE 95.00% | CHM0031821 | 1G | $945.95 |
| METHYL N-4-BOC-N-1-CBZ-2-PIPERAZINECARBOXYLATE 95.00% | CHM0031821 | 5G | $1334.03 |
| 1-Benzyl4-tert-butyl2-methylpiperazine-1,2,4-tricarboxylate | 5055AJ | 10g | $448 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| NFPA 704 |
|
METHYL N-4-BOC-N-1-CBZ-2-PIPERAZINECARBOXYLATE price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B130270 | 1-Benzyl4-tert-Butyl2-MethylPiperazine-1,2,4-tricarboxylate | 126937-42-6 | 50mg | $45 | 2021-12-16 | Buy |
| TRC | B130270 | 1-Benzyl4-tert-Butyl2-MethylPiperazine-1,2,4-tricarboxylate | 126937-42-6 | 500mg | $130 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0031821 | METHYL N-4-BOC-N-1-CBZ-2-PIPERAZINECARBOXYLATE 95.00% | 126937-42-6 | 1G | $945.95 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0031821 | METHYL N-4-BOC-N-1-CBZ-2-PIPERAZINECARBOXYLATE 95.00% | 126937-42-6 | 5G | $1334.03 | 2021-12-16 | Buy |
| AK Scientific | 5055AJ | 1-Benzyl4-tert-butyl2-methylpiperazine-1,2,4-tricarboxylate | 126937-42-6 | 10g | $448 | 2021-12-16 | Buy |
METHYL N-4-BOC-N-1-CBZ-2-PIPERAZINECARBOXYLATE Chemical Properties,Uses,Production
Application
METHYL N-4-BOC-N-1-CBZ-2-PIPERAZINECARBOXYLATE, also known as 1-benzyl4-(tert-butyl)2-methylpiperazine-1,2,4-tricarboxylate, is a pharmaceutical intermediate that can be obtained by esterification with piperazine-2-carboxylic acid as a starting material, followed by Boc protection, Cbz protection, and finally iodomethane.
Synthesis
The fully protected Methyl N-4-Boc-N-1-Cbz-2-piperazinecarboxylate was prepared from 2-piperazinecarboxylic acid as shown in the below figure. Using a sequential one-pot protection procedure similar to that used to protect lysine, a solution of 2-piperazinecarboxylic acid (24.1 g, 0.185 mol) in 1:1 dioxane-water (1.2 L) was maintained at pH 11 with 50% aqueous sodium hydroxide during the addition of a solution of 2-(t-butyloxycarbonyloxyimino)-2-phenylacetonitrile (BOC-ON, 51 g, 0.21 mol) in dioxane (0.3 L). After 3 h, the reaction mixture was cooled in an ice bath and the pH was adjusted to pH 9.5 with 6 N HCl. Benzylchloroformate was added dropwise to the cold solution while maintaining the pH with 50% aqueous sodium hydroxide. The reaction was warmed to room temperature and stirred for 24 h. The solution was washed with diethyl ether (4 x 250 mL), the aqueous layer was acidified to pH 2 and extracted with ethyl acetate (4 x 250 mL) . The organic layer was dried over magnesium sulfate, filtered and evaporated to give a pale yellow oil.
The methyl ester 5(Methyl N-4-Boc-N-1-Cbz-2-piperazinecarboxylate) was obtained by treatment of a tetrahydrofuran solution of the crude acid with excess diazomethane. Alternatively, the methyl ester could be obtained on large scale by treatment of a saturated sodium bicarbonate solution of the intermediate carboxylic acid 4 with a methylene chloride solution of methyl iodide and Adogen 464, or preferably by refluxing an acetone solution of the carboxylic acid, dimethyisulfate and potassium carbonate.[1]
References
[1] CHRISTOPHER F BIGGE ∗. New preparations of the N-methyl-D-aspartate receptor antagonist, 4-(3-phosphonopropyl)-2-piperazinecarboxylic acid (CPP)[J]. Tetrahedron Letters, 1989, 30 39: Pages 5193-5196. DOI:10.1016/S0040-4039(01)93739-6.
METHYL N-4-BOC-N-1-CBZ-2-PIPERAZINECARBOXYLATE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9545 | 58 |
| Shanghai Rlavie Technology Co ltd | +86-021-67759270 +8617717059219 | sales@rlavie.com | China | 1030 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +8618118463618 | sales1@artkmedchem.com | China | 39020 | 58 |
View Lastest Price from METHYL N-4-BOC-N-1-CBZ-2-PIPERAZINECARBOXYLATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2022-04-22 | Methyl 4-Boc-1-Cbz-2-piperazinecarboxylate
126937-42-6
|
US $0.00-0.00 / kg | 0.001kg | 98%min | 100kgs/month | Shanghai Rlavie Technology Co ltd |
-
- Methyl 4-Boc-1-Cbz-2-piperazinecarboxylate
126937-42-6
- US $0.00-0.00 / kg
- 98%min
- Shanghai Rlavie Technology Co ltd
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