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7-(2-HYDROXYETHYL)THEOPHYLLINE

7-(2-HYDROXYETHYL)THEOPHYLLINE structure

CAS No.: 519-37-9

Chemical Name:: 7-(2-HYDROXYETHYL)THEOPHYLLINE

Synonyms: ETOFYLLINE;Etofylline CRS;Oxyethyltheophylline;7-(BETA-HYDROXYETHYL)THEOPHYLLINE;7-(2-Hydroxyethyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione;KT 200G;Cordalin;Etofyllin;NSC 113373;Oxyphyllin

CBNumber:: CB2333122

Molecular Formula:: C9H12N4O3

Molecular Weight:: 224.22

MDL Number:: MFCD00055055

MOL File:: 519-37-9.mol

MSDS File:: SDS

Last updated:2025-11-10 14:44:25

Product description	Number	Pack Size	Price
Theophylline Related Compound F Pharmaceutical Secondary Standard; Certified Reference Material	PHR2541	100MG	$546
Etofylline European Pharmacopoeia (EP) Reference Standard	E2500000	20 mg	$153
Theophylline Related Compound F United States Pharmacopeia (USP) Reference Standard	1653060	25mg	$1840
7-(β-Hydroxyethyl)theophylline solid	H9006	25g	$104
Theophylline Related Compound F Pharmaceutical Secondary Standard; Certified Reference Material	PHR2588	100MG	$443
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7-(2-HYDROXYETHYL)THEOPHYLLINE Properties

Melting point	163°C
Boiling point	365.61°C (rough estimate)
Density	1.3055 (rough estimate)
refractive index	1.6300 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	H₂O: Solutions may be stored for several days at 4°C.soluble
pka	14.48±0.10(Predicted)
form	solid
color	white
Water Solubility	2.991g/L(temperature not stated)
Merck	14,3878
CAS DataBase Reference	519-37-9(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	L164909TBI
UNSPSC Code	41106305
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

Hazard Codes

Risk Statements

Safety Statements

WGK Germany

RTECS

XH5850000

HS Code

2939590000

NFPA 704

	0
2		0

7-(2-HYDROXYETHYL)THEOPHYLLINE price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR2541	Theophylline Related Compound F Pharmaceutical Secondary Standard; Certified Reference Material	519-37-9	100MG	$546	2025-07-31	Buy
Sigma-Aldrich	E2500000	Etofylline European Pharmacopoeia (EP) Reference Standard	519-37-9	20 mg	$153	2025-07-31	Buy
Sigma-Aldrich	1653060	Theophylline Related Compound F United States Pharmacopeia (USP) Reference Standard	519-37-9	25mg	$1840	2025-07-31	Buy
Sigma-Aldrich	H9006	7-(β-Hydroxyethyl)theophylline solid	519-37-9	25g	$104	2023-01-07	Buy
Sigma-Aldrich	PHR2588	Theophylline Related Compound F Pharmaceutical Secondary Standard; Certified Reference Material	519-37-9	100MG	$443	2022-05-15	Buy

Product number	Packaging	Price	Buy
PHR2541	100MG	$546	Buy
E2500000	20 mg	$153	Buy
1653060	25mg	$1840	Buy
H9006	25g	$104	Buy
PHR2588	100MG	$443	Buy

7-(2-HYDROXYETHYL)THEOPHYLLINE Chemical Properties,Uses,Production

Chemical Properties

White Solid

Originator

Duolip,Merckle,W. Germany,1981

Uses

Useful synthetic intermediate in the preparation of 7-substituted xanthines.

Uses

Cardiac analeptic;Phosphodiesterase inhibitor

Uses

An inhibitor of 3’,5’-Cyclic Nucleotide Phosphodiesterase. Therapeutically, this compound has diuretic, muscle relaxant, bronchial dilation and CNS stimulant activities.

Definition

ChEBI: 7-(2-hydroxyethyl)-1,3-dimethylpurine-2,6-dione is an oxopurine.

Manufacturing Process

107.3 g (0.5 mol) 2-(p-chlorophenoxy)isobutyric acid and 56.0 g (0.25 mol) 7-hydroxyethyltheophylline were suspended together in 250 ml xylene. They were heated together for 15 hours in a water separator following the addition of 1.5 g p-toluenesulfonic acid. The solution was next agitated with dilute sodium bicarbonate solution (0.5 mol NaHCO3), water washed and evaporated in a rotary evaporator.
The residue was then crystallized from isopropanol, yielding 58.0 g (55% yield) of 1-(7-theophyllinyl)-2-ethyl[2-(p-chlorophenoxy)-isobutyrate] . The compound had a melting point of 131°C to 132°C.

Therapeutic Function

Antihyperlipidemic

Biochem/physiol Actions

Pharmacological profile similar to theophylline.

7-(2-HYDROXYETHYL)THEOPHYLLINE Preparation Products And Raw materials

Raw materials

2-(4-Chlorophenoxy)-2-methylpropionic acid

Preparation Products

2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl nicotinate 1H-Purine-2,6-dione, 7-[2-(acetyloxy)ethyl]-3,7-dihydro-1,3-dimethyl-

7-(2-HYDROXYETHYL)THEOPHYLLINE Suppliers

Global( 241)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29798	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 +86-17392581500	1015@dideu.com	China	3987	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32435	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15120	58
Aston Chemical	13000000000	sales@astonchem.com	United States	1634	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Hubei Jusheng Technology Co.,Ltd.	58
Standardpharm Co. Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
TargetMol Chemicals Inc.	58
AFINE CHEMICALS LIMITED	58
Aston Chemical	58
Dayang Chem (Hangzhou) Co.,Ltd.	58

View Lastest Price from 7-(2-HYDROXYETHYL)THEOPHYLLINE manufacturers

Update time	Product	Price	Purity	Supply Ability	Manufacturer
2025-11-10	Etofylline 519-37-9	US $0.00 / removed	99.53%	10g	TargetMol Chemicals Inc.
2025-11-10	Etofylline 519-37-9	US $0.00 / removed	99.53%	10g	TargetMol Chemicals Inc.
2025-04-30	Etofylline 519-37-9	US $42.00 / mg	99.53%	10g	TargetMol Chemicals Inc.

Etofylline
519-37-9
US $0.00 / removed
99.53%
TargetMol Chemicals Inc.

Etofylline
519-37-9
US $0.00 / removed
99.53%
TargetMol Chemicals Inc.

Etofylline
519-37-9
US $42.00 / mg
99.53%
TargetMol Chemicals Inc.

7-(2-HYDROXYETHYL)THEOPHYLLINE Spectrum

7-(2-HYDROXYETHYL)THEOPHYLLINE(519-37-9)MS 7-(2-HYDROXYETHYL)THEOPHYLLINE(519-37-9)¹HNMR 7-(2-HYDROXYETHYL)THEOPHYLLINE(519-37-9)¹³CNMR 7-(2-HYDROXYETHYL)THEOPHYLLINE(519-37-9)IR1 7-(2-HYDROXYETHYL)THEOPHYLLINE(519-37-9)IR2

519-37-9(7-(2-HYDROXYETHYL)THEOPHYLLINE)Related Search:

Tazifylline PROXYPHYLLINE Theophylline-7-acetic acid Diprophylline Doxofylline

Xanthinol nicotinate ETOFYLLINE CLOFIBRATE 7-(2-HYDROXYETHYL)THEOPHYLLINE Theophylline 1,3-DIMETHYL-7-(OXIRAN-2-YLMETHYL)-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE

8-CHLORO-7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 8-BROMO-7-[2-(4-CHLOROPHENOXY)ETHYL]-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE ETHYL 2-(8-CHLORO-1,3-DIMETHYL-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-7-YL)ACETATE 7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-8-MORPHOLINO-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE

ETHYL 2-(8-BROMO-1,3-DIMETHYL-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-7-YL)ACETATE 8-BROMO-7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-8-NITRO-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE

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ETOFYLLINE EPE(CRM STANDARD) ETOFYLLINE MM(CRM STANDARD) 7-(2-HYDROXYETHYL)THEOPHYLLINE 98+% ETOFYLLINE (BETA-HYDROXYETHYLTHEOPHYLLINE) Phyllocormin ETOFYLLINE BETA-HYDROXYETHYLTHEOPHYLLINE BIOPHYLLINE THEOPHYLLINE, 7-(BETA-HYDROXYETHYL) 7-(2-hydroxyethyl)-1,3-dimethyl-purine-2,6-dione 7-(2-hydroxyethyl)-1,3-dimethylpurine-2,6-dione KT 200G NSC 113373 Oxyethophylline Oxyphyllin 7-(2-Hydroxyethyl)-1,3-diMethyl-3,7-dihydro-1H-purine-2,6-dione,97% 7-(2-Hydroxyethyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione Theophylline EP Impurity F Theophylline Related Compound F 7-(A-HYDROXYETHYL)THEOPHYLLINE 7-(BETA-HYDROXYETHYL)THEOPHYLLINE 7-(2-HYDROXYETHYL)THEOPHYLLINE 1,3-DIMETHYL-7-(BETA-HYDROXYETHYL)XANTHINE 1,3-DIMETHYL-7-[2-HYDROXYETHYL]-XANTHINE 1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxyethyl)-1,3-dimethyl- 3,7-Dihydro-7-(2-hydroxyethyl)-1,3-dimethyl-1H-purine-2,6-dione 3,7-dihydro-7-(2-hydroxyethyl)-1,3-dimethyl-1h-purine-6-dione oxphylline(amido) Oxyaethyltheophyllin Oxyethyltheophylline Oxyphylline Oxytheonyl Phyllocormin N phyllocorminn Sklerodormal Soluphylline Theophylline, 7-(2-hydroxyethyl)- Etofyllin Diprophylline Impurity 3（Diprophylline EP Impurity C） Theophylline-ethylenediamine Impurity 6（Theophylline-ethylenediamine EP Impurity F） Diprophylline EP Impurity C 7-(Hydroxyethyl)theophylline 7-Theophyllineethanol Aethophyllinum Ascorphylline b-hydroxyethyltheophylline Cordalin Corophyllin-N Dilaphyllin Frekaphyllin Hydroxyethyl theophyline Hydroxyethyltheophylline Oxphylline Oxphylline (Amido) 7-(2-Hydroxyethyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione 7-(2-Hydroxyethyl)-1,3-dimethylxanthine 7-(2-hydroxyethyl)-theophyllin Hydroxuethyl theophylline