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ChemicalBook >> CAS DataBase List >>(R)-5,7-difluorochroman-4-ol

(R)-5,7-difluorochroman-4-ol

(R)-5,7-difluorochroman-4-ol Structure
(R)-5,7-difluorochroman-4-ol structure
CAS No.
1270294-05-7
Chemical Name:
(R)-5,7-difluorochroman-4-ol
Synonyms
(4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol;Tegoprazan Impurity;Tegoprazan Impurity 11;R-5,7-difluorobenzo dihydropyran-4-ol;Tegoprazan side chain;Tegoprazan ImpuritiesC;Tigora produced impurity 11;(R)-5, 7-difluorobenzopyrane-4-ol;(R)-5,7-Difluorochroman-4-ol ，Tegoprazan intermdiate;2H-1-Benzopyran-4-ol, 5,7-difluoro-3,4-dihydro-, (4R)-
CBNumber:
CB23354564
Molecular Formula:
C9H8F2O2
Molecular Weight:
186.16
MDL Number:
MFCD09763634
MOL File:
1270294-05-7.mol
MSDS File:
SDS
Last updated:2026-05-28 00:19:40
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(R)-5,7-difluorochroman-4-ol Properties

Boiling point 228.4±40.0 °C(Predicted)
Density 1.402±0.06 g/cm3(Predicted)
storage temp. Storage temp. 2-8°C
pka 13.09±0.20(Predicted)
Appearance White to off-white Solid
InChI InChI=1S/C9H8F2O2/c10-5-3-6(11)9-7(12)1-2-13-8(9)4-5/h3-4,7,12H,1-2H2/t7-/m1/s1
InChIKey HGTYMLFMXKYIQW-SSDOTTSWSA-N
SMILES C1OC2=CC(F)=CC(F)=C2[C@H](O)C1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

(R)-5,7-difluorochroman-4-ol price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth VAC29405 (4R)-5,7-Difluoro-3,4-dihydro-2H-1-benzopyran-4-ol 1270294-05-7 5g $437.5 2026-06-05 Buy
Synthonix D82158 (4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol 97% 1270294-05-7 250mg $51 2026-05-06 Buy
Synthonix D82158 (4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol 97% 1270294-05-7 500mg $57 2026-05-06 Buy
Synthonix D82158 (4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol 97% 1270294-05-7 1g $60 2026-05-06 Buy
Synthonix D82158 (4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol 97% 1270294-05-7 5g $160 2026-05-06 Buy
Product number Packaging Price Buy
VAC29405 5g $437.5 Buy
D82158 250mg $51 Buy
D82158 500mg $57 Buy
D82158 1g $60 Buy
D82158 5g $160 Buy

(R)-5,7-difluorochroman-4-ol Chemical Properties, Uses, Production

Uses

(R)-5,7-difluorochroman-4-ol is an important intermediate in the synthesis of tegoprazan[1].

Production Methods

Preparing (R)-5,7-difluorochroman-4-ol involves taking 5, 7-difluorochroman-4-one as substrate and performing asymmetric reduction reaction in the presence of ketoreductase, coenzyme and coenzyme circulating system to obtain (R)-5,7-difluorochroman-4-ol, where ketoreductase is one or combination of two or more of short-chain dehydrogenases/reductases family (SDR), medium-chain dehydrogenases/reductase (MDR) or aldo-Keto reductase (AKR)[1].

References

[1]PAN X, et al. "Preparing (R)-5,7-difluorochroman-4-ol involves taking 5, 7-difluorochroman-4-one as substrate, and performing asymmetric reduction reaction in the presence of ketoreductase, coenzyme and coenzyme circulating system to obtain (R)-5,7-difluorochroman-4-ol.", CN202210486605.0. 2022.

(R)-5,7-difluorochroman-4-ol Preparation Products And Raw materials

Raw materials

1-Bromo-4-chloro-1,1,2,2-tetrafluorobutane 5,7-difluorochroman-4-one

Preparation Products

(R)-5,7-difluorochroman-4-ol Suppliers

Global Suppliers ( 171)
Supplier Tel Email Country ProdList Advantage
Sichuan Dingke Pharmaceutical Co Ltd +86-13658330453; 13658330453 sale@dingkepharma.com China 32 58
CE Pharm Co.,Ltd 15317222985 xin.yu@cepharm.cn China 160 58
Anhui Jianzhu Biotechnology Co., Ltd. 15855184105 3150278607@qq.com China 64 58
Shandong Winner Biotechnology Co., Ltd. 15315319889 15315319889 wannaswsw@163.com China 388 58
Hangzhou WDJBIO Co., Ltd. 0571-86706360 18158111080 3168409019@qq.com China 579 58
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9409 55
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD. 21-33585366 13311639313 sales@shyrchem.com China 818 55
Shanghai Arbor Chemical Co., Ltd. 021-60451683 15021268886 sales@arborchemical.com China 859 55
Hunan Furui Biopharma Technology Co., Ltd. 15901640172，19275032510 15901640172 sales03@hn-furui.com China 380 55
Hunan HuaTeng Pharmaceutical Co., Ltd., 400-8592883 15367835770 sales@huatengsci.com China 5869 58
Supplier Advantage
Sichuan Dingke Pharmaceutical Co Ltd 58
CE Pharm Co.,Ltd 58
Anhui Jianzhu Biotechnology Co., Ltd. 58
Shandong Winner Biotechnology Co., Ltd. 58
Hangzhou WDJBIO Co., Ltd. 58
Beijing HwrkChemical Technology Co., Ltd 55
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD. 55
Shanghai Arbor Chemical Co., Ltd. 55
Hunan Furui Biopharma Technology Co., Ltd. 55
Hunan HuaTeng Pharmaceutical Co., Ltd., 58

View Latest Price from (R)-5,7-difluorochroman-4-ol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R)-5,7-difluorochroman-4-ol pictures 2026-10-21 (R)-5,7-difluorochroman-4-ol
1270294-05-7
 99.99% 20 tons Zibo Hangyu Biotechnology Development Co., Ltd
(R)-5,7-difluorochroman-4-ol pictures 2026-08-25 (R)-5,7-difluorochroman-4-ol
1270294-05-7
 $2.00-5.00 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
(R)-5,7-difluorochroman-4-ol pictures 2026-08-08 (R)-5,7-difluorochroman-4-ol
1270294-05-7
 99.0%min 2000kg Hangzhou ICH Biofarm Co., Ltd

(R)-5,7-difluorochroman-4-ol Spectrum

(R)-5,7-difluorochroman-4-ol(1270294-05-7)1HNMR

1270294-05-7 ((R)-5,7-difluorochroman-4-ol) Related Search:

1-benzyl-4-hydroxy-2-methyl-1H-benzo[d]imidazole-6-carboxylic acid Dimethoxymethane 1-benzyl-2-methyl-1H-imidazole-carbaldehyde 1H-Benzimidazole-6-carboxylic acid, 4-hydroxy-2-methyl-1-(phenylmethyl)-, ethyl ester 5,7-difluorochroman-4-one
(Dimethylamino)acetaldehyde Dimethyl Acetal 2-Aminobiphenyl 1-(piperidine-4-carbonyl)piperidine-4-carboxylic acid hydrochloride Butanedioic acid, 2-[[2-methyl-1-(phenylmethyl)-1H-imidazol-5-yl]methylene]-, 1-ethyl ester, (2E)- 1H-Benzimidazole-6-carboxamide, 4-hydroxy-N,N,2-trimethyl-1-(phenylmethyl)-
Benzoic acid, 4-[[4-(aminocarbonyl)-1-piperidinyl]methyl]- Revefenacin Impurity 16 Dibenzofuran

1of3

2H-1-Benzopyran-4-ol, 5,7-difluoro-3,4-dihydro-, (4R)- R-5,7-difluorobenzo dihydropyran-4-ol Tegoprazan Impurity 11 [2-(2-chlorophenyl)ethanamine, 1-Amino-2-(2-chlorophenyl)ethane, 2-(2-Chlorophenyl)ethylamine] (R)-5, 7-difluorobenzopyrane-4-ol Tegoprazan side chain Tegoprazan ImpuritiesC Tigora produced impurity 11 (4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol - [D82158] (R)-5,7-Difluorochroman-4-ol ，Tegoprazan intermdiate (4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol Tegoprazan Impurity 1270294-05-7 API