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(R)-5,7-difluorochroman-4-ol

(R)-5,7-difluorochroman-4-ol structure

CAS No.: 1270294-05-7

Chemical Name:: (R)-5,7-difluorochroman-4-ol

Synonyms: (4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol;Tegoprazan Impurity;Tegoprazan Impurity 11;R-5,7-difluorobenzo dihydropyran-4-ol;Tegoprazan side chain;Tegoprazan ImpuritiesC;Tigora produced impurity 11;(R)-5, 7-difluorobenzopyrane-4-ol;(R)-5,7-Difluorochroman-4-ol ，Tegoprazan intermdiate;2H-1-Benzopyran-4-ol, 5,7-difluoro-3,4-dihydro-, (4R)-

CBNumber:: CB23354564

Molecular Formula:: C9H8F2O2

Molecular Weight:: 186.16

MDL Number:: MFCD09763634

MOL File:: 1270294-05-7.mol

MSDS File:: SDS

Last updated:2026-05-28 00:19:40

Product description	Number	Pack Size	Price
(4R)-5,7-Difluoro-3,4-dihydro-2H-1-benzopyran-4-ol	VAC29405	5g	$437.5
(4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol 97%	D82158	250mg	$51
(4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol 97%	D82158	500mg	$57
(4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol 97%	D82158	1g	$60
(4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol 97%	D82158	5g	$160

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(R)-5,7-difluorochroman-4-ol Properties

Boiling point	228.4±40.0 °C(Predicted)
Density	1.402±0.06 g/cm3(Predicted)
storage temp.	Storage temp. 2-8°C
pka	13.09±0.20(Predicted)
Appearance	White to off-white Solid
InChI	InChI=1S/C9H8F2O2/c10-5-3-6(11)9-7(12)1-2-13-8(9)4-5/h3-4,7,12H,1-2H2/t7-/m1/s1
InChIKey	HGTYMLFMXKYIQW-SSDOTTSWSA-N
SMILES	C1OC2=CC(F)=CC(F)=C2[C@H](O)C1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

(R)-5,7-difluorochroman-4-ol price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	VAC29405	(4R)-5,7-Difluoro-3,4-dihydro-2H-1-benzopyran-4-ol	1270294-05-7	5g	$437.5	2026-06-05	Buy
Synthonix	D82158	(4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol 97%	1270294-05-7	250mg	$51	2026-05-06	Buy
Synthonix	D82158	(4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol 97%	1270294-05-7	500mg	$57	2026-05-06	Buy
Synthonix	D82158	(4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol 97%	1270294-05-7	1g	$60	2026-05-06	Buy
Synthonix	D82158	(4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol 97%	1270294-05-7	5g	$160	2026-05-06	Buy

Product number	Packaging	Price	Buy
VAC29405	5g	$437.5	Buy
D82158	250mg	$51	Buy
D82158	500mg	$57	Buy
D82158	1g	$60	Buy
D82158	5g	$160	Buy

(R)-5,7-difluorochroman-4-ol Chemical Properties,Uses,Production

Uses

(R)-5,7-difluorochroman-4-ol is an important intermediate in the synthesis of tegoprazan[1].

Production Methods

Preparing (R)-5,7-difluorochroman-4-ol involves taking 5, 7-difluorochroman-4-one as substrate and performing asymmetric reduction reaction in the presence of ketoreductase, coenzyme and coenzyme circulating system to obtain (R)-5,7-difluorochroman-4-ol, where ketoreductase is one or combination of two or more of short-chain dehydrogenases/reductases family (SDR), medium-chain dehydrogenases/reductase (MDR) or aldo-Keto reductase (AKR)[1].

References

[1]PAN X, et al. "Preparing (R)-5,7-difluorochroman-4-ol involves taking 5, 7-difluorochroman-4-one as substrate, and performing asymmetric reduction reaction in the presence of ketoreductase, coenzyme and coenzyme circulating system to obtain (R)-5,7-difluorochroman-4-ol.", CN202210486605.0. 2022.

(R)-5,7-difluorochroman-4-ol Preparation Products And Raw materials

Raw materials

1-BROMO-4-CHLORO-1,1,2,2-TETRAFLUOROBUTANE 5,7-difluorochroman-4-one

Preparation Products

(R)-5,7-difluorochroman-4-ol Suppliers

Global( 170)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1002	58
Joyochem Co.,Ltd	+86-0531-82687998 +8615153169511	sales01@joyochem.com	China	30	58
ChemExpress	+86-19370970350 +86-021-58950125	info@chemexpress.com	China	790	58
Zhengzhou Anbu Chem Co.,Ltd	+86-0371-88006763; +86-15988602810	sales@anbuchem.com	China	3108	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-15225627621 +86-13213167925	jiuyitime@fdachem.com	China	16505	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14034	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10399	58
Shanghai Worldyang Chemical Co.,Ltd.	+86-021-56795779 +86-13651600618	sales@worldyachem.com	China	963	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413	contact@trustwe.com	China	5742	58

Supplier	Advantage
Hangzhou ICH Biofarm Co., Ltd	58
Joyochem Co.,Ltd	58
ChemExpress	58
Zhengzhou Anbu Chem Co.,Ltd	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Shenzhen Nexconn Pharmatechs Ltd	58
Shanghai Worldyang Chemical Co.,Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58

View Lastest Price from (R)-5,7-difluorochroman-4-ol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-16	(R)-5,7-difluorochroman-4-ol 1270294-05-7			99.99%	20 tons	Zibo Hangyu Biotechnology Development Co., Ltd
2026-08-08	(R)-5,7-difluorochroman-4-ol 1270294-05-7			99.0%min	2000kg	Hangzhou ICH Biofarm Co., Ltd
2026-07-02	(R)-5,7-difluorochroman-4-ol 1270294-05-7	$2.00-5.00	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

(R)-5,7-difluorochroman-4-ol
1270294-05-7
$0.10
99.99%
Zibo Hangyu Biotechnology Development Co., Ltd

(R)-5,7-difluorochroman-4-ol
1270294-05-7
99.0%min
Hangzhou ICH Biofarm Co., Ltd

(R)-5,7-difluorochroman-4-ol
1270294-05-7
$2.00-5.00
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

(R)-5,7-difluorochroman-4-ol Spectrum

(R)-5,7-difluorochroman-4-ol(1270294-05-7)¹HNMR

1270294-05-7((R)-5,7-difluorochroman-4-ol)Related Search:

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(Dimethylamino)acetaldehyde Dimethyl Acetal 2-Aminobiphenyl 1-(piperidine-4-carbonyl)piperidine-4-carboxylic acid hydrochloride Butanedioic acid, 2-[[2-methyl-1-(phenylmethyl)-1H-imidazol-5-yl]methylene]-, 1-ethyl ester, (2E)- 1H-Benzimidazole-6-carboxamide, 4-hydroxy-N,N,2-trimethyl-1-(phenylmethyl)-

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2H-1-Benzopyran-4-ol, 5,7-difluoro-3,4-dihydro-, (4R)- R-5,7-difluorobenzo dihydropyran-4-ol Tegoprazan Impurity 11 [2-(2-chlorophenyl)ethanamine, 1-Amino-2-(2-chlorophenyl)ethane, 2-(2-Chlorophenyl)ethylamine] (R)-5, 7-difluorobenzopyrane-4-ol Tegoprazan side chain Tegoprazan ImpuritiesC Tigora produced impurity 11 (4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol - [D82158] (R)-5,7-Difluorochroman-4-ol ，Tegoprazan intermdiate (4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol Tegoprazan Impurity 1270294-05-7 API