ODVWZAKKCNHATB-UHFFFAOYSA-N
- CAS No.
- 2108899-91-6
- Chemical Name:
- ODVWZAKKCNHATB-UHFFFAOYSA-N
- Synonyms
- ODVWZAKKCNHATB-UHFFFAOYSA-N;CPTH2 hydrochloride , CPTH2 HCl;CPTH2 (hydrochloride) (357649-93-5 free base);2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone-cyclopentanone,monohydrochloride
- CBNumber:
- CB23402948
- Molecular Formula:
- C14H15Cl2N3S
- Molecular Weight:
- 328.26
- MDL Number:
- MOL File:
- 2108899-91-6.mol
ODVWZAKKCNHATB-UHFFFAOYSA-N price More Price(2)
ODVWZAKKCNHATB-UHFFFAOYSA-N Chemical Properties,Uses,Production
Description
Gcn5 is a chromatin modifying factor whose HAT activity is required to acetylate histone H3 lysine 9 (K9) and K14, which facilitates transcription elongation by relaxing nucleosomes. CPTH2 inhibits the HAT activity of Gcn5 both in vitro and in vivo, reducing histone H3K14 acetylation at a concentration of 0.8 mM. It is a useful tool to study the impact of Gcn5-
Uses
CPTH2 hydrochloride is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 hydrochloride selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 hydrochloride induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B)[1][2].
IC 50
GCN5
References
[1] Cocco E, et al. KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumoraggressiveness and target of KAT inhibitor CPTH2. Clin Epigenetics. 2018 Apr 4;10:44. DOI:10.1186/s13148-018-0473-4
[2] Chimenti F, et al. A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. J Med Chem. 2009 Jan 22;52(2):530-6. DOI:10.1021/jm800885d
ODVWZAKKCNHATB-UHFFFAOYSA-N Preparation Products And Raw materials
Raw materials
Preparation Products
ODVWZAKKCNHATB-UHFFFAOYSA-N Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4922 | 55 |
| Angel Pharmatech, Ltd. | 17317130613 | 3358272972@qq.com | China | 3271 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24989 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Shaoguan Qicheng Biotechnology Co., Ltd | 18122215013 | 780229652@qq.com | China | 1286 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
View Lastest Price from ODVWZAKKCNHATB-UHFFFAOYSA-N manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-07-27 | CPTH2 (hydrochloride) (357649-93-5 free base)
2108899-91-6
|
US $0.00-0.00 / mg | 10g | TargetMol Chemicals Inc. |
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- CPTH2 (hydrochloride) (357649-93-5 free base)
2108899-91-6
- US $0.00-0.00 / mg
- TargetMol Chemicals Inc.
