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4-Methoxy-2,5-dimethyl-3(2H)-furanone

4-Methoxy-2,5-dimethyl-3(2H)-furanone Structure
4-Methoxy-2,5-dimethyl-3(2H)-furanone structure
CAS No.
4077-47-8
Chemical Name:
4-Methoxy-2,5-dimethyl-3(2H)-furanone
Synonyms
FEMA 3664;mesifuran;Mesifurane;FURANEOL METHYL ETHER;3(2H)-Furanone, 4-methoxy-2,5-dimethyl-;Methoxyfuraneol;UNII:3241BIM975;FRAISION METHYL ETHER;Furfuran ketone methyl ether;2,5-Dimethyl-4-Methoxy-2,3-Dih
CBNumber:
CB2350879
Molecular Formula:
C7H10O3
Molecular Weight:
142.15
MDL Number:
MFCD00209504
MOL File:
4077-47-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:21:13
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4-Methoxy-2,5-dimethyl-3(2H)-furanone Properties

Boiling point 63°C/0.3mmHg(lit.)
Density 1.097 g/mL at 25 °C(lit.)
refractive index n20/D 1.478(lit.)
FEMA 3664 | 2,5-DIMETHYL-4-METHOXY-3(2H)-FURANONE
FLAVIS Number 13.089 | 2,5-Dimethyl-4-methoxyfuran-3(2H)-one
Flash point 167 °F
storage temp. 2-8°C
form clear liquid
color Colorless to Yellow
Specific Gravity 1.097
Odor at 1.00 % in dipropylene glycol. sweet moldy mushroom vegetable potato burnt sugar nut skin wasabi caramellic fruity brandy
Odor Type moldy
biological source synthetic
JECFA Number 1451
Major Application flavors and fragrances
InChI 1S/C7H10O3/c1-4-6(8)7(9-3)5(2)10-4/h4H,1-3H3
InChIKey SIMKGHMLPVDSJE-UHFFFAOYSA-N
SMILES COC1=C(C)OC(C)C1=O
LogP 0.54
CAS DataBase Reference 4077-47-8(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) 2,5-DIMETHYL-4-METHOXY-3(2H)-FURANONE
EWG's Food Scores 1
FDA UNII 3241BIM975
NIST Chemistry Reference 3(2H)-furanone, 4-methoxy-2,5-dimethyl-(4077-47-8)
EPA Substance Registry System 3(2H)-Furanone, 4-methoxy-2,5-dimethyl- (4077-47-8)
UNSPSC Code 12164502
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  22
Safety Statements  24/25
WGK Germany  3
TSCA  TSCA listed
HS Code  29329990
Storage Class 10 - Combustible liquids
Hazard Classifications Acute Tox. 4 Oral
NFPA 704
2
1 0

4-Methoxy-2,5-dimethyl-3(2H)-furanone price More Price(63)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W366412 2,5-Dimethyl-4-methoxy-3(2H)-furanone natural, ≥98%, FG 4077-47-8 1 each $66 2026-04-30 Buy
Sigma-Aldrich W366412 2,5-Dimethyl-4-methoxy-3(2H)-furanone natural, ≥98%, FG 4077-47-8 100g $205 2026-04-30 Buy
Sigma-Aldrich W366412 2,5-Dimethyl-4-methoxy-3(2H)-furanone natural, ≥98%, FG 4077-47-8 1kg $1480 2026-04-30 Buy
Sigma-Aldrich W366404 2,5-Dimethyl-4-methoxy-3(2H)-furanone ≥97%, FG 4077-47-8 1 each $55.9 2026-04-30 Buy
Sigma-Aldrich W366404 2,5-Dimethyl-4-methoxy-3(2H)-furanone ≥97%, FG 4077-47-8 100g $209 2026-04-30 Buy
Product number Packaging Price Buy
W366412 1 each $66 Buy
W366412 100g $205 Buy
W366412 1kg $1480 Buy
W366404 1 each $55.9 Buy
W366404 100g $209 Buy

4-Methoxy-2,5-dimethyl-3(2H)-furanone Chemical Properties, Uses, Production

Synthesis

Synthesis of 4077-47-8

In a 1000 mL three-necked flask, 300 g of tetrahydrofuran and 26 g of sodium hydride were added. While stirring and cooling to 0–5 °C, 120 g of natural ethyl lactate was added dropwise. After reacting for 30 minutes, the reaction solution was heated to 60 °C, and 74 g of natural crotonitrile was added dropwise. After the addition was completed over two hours, the mixture was refluxed to obtain nitrile furanone with a yield of 96%. The nitrile furanone was then oxidized with potassium persulfate, and refluxed with water as the solvent. The mixture was then subjected to pyrolysis of the nitrile using a strong-base anion exchange resin, Dowex 2, to obtain furanone with a yield of 28%.

Take 60 g of the natural equivalent furanone obtained by the above method, 480 g of natural methanol, and 3 g of p-toluenesulfonic acid, add them to a 1000 mL three-necked flask, and reflux for 8 hours. Cool the reaction solution to room temperature, add 90 g of sodium bicarbonate, stir for 30 minutes, and then filter off the sodium bicarbonate. Distill methanol under normal pressure until no more distillate is obtained, then distill 4-Methoxy-2,5-dimethyl-3(2H)-furanone under reduced pressure, yielding a purity of 97% and a molar yield of 65%.

Chemical Properties

2,5-Dimethyl-4-methoxy-3(2H)-furanone has a sweet, cooked caramellic, burnt sugar odor

Occurrence

Taste characteristics at 1.0–5.0 ppm:musty, vegetative,savorymeaty with a brown jamy fullnessin the aftertaste. Natural occurrence: Reported found in grape, mango, pineapple, wild raspberry, wild strawberry, (Fragaria vesca), cultivated strawberry, strawberry wine, strawberry jam, blackberries, kiwifruit and Cape gooseberry.

Uses

flavors and fragrances

Definition

ChEBI: Mesifurane is a member of oxolanes.

General Description

2,5-Dimethyl-4-methoxy-3(2H)-furanone is one of the key volatile aroma compounds that contribute to the characteristic aroma of strawberries.

Biochem/physiol Actions

Odor at 1.0% PG

4-Methoxy-2,5-dimethyl-3(2H)-furanone synthesis

67-56-1
3658-77-3
4077-47-8
Synthesis of 4-Methoxy-2,5-dimethyl-3(2H)-furanone from Methanol and Furaneol

4-Methoxy-2,5-dimethyl-3(2H)-furanone Preparation Products And Raw materials

Raw materials

Furaneol Methanol

Preparation Products

4-Methoxy-2,5-dimethyl-3(2H)-furanone Suppliers

Global Suppliers ( 222)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
jiliang chemicals 21-62165282 bidingchem@163.com China 1395 60
Maya High Purity Chemicals +86 (573) 82222445 (0)18006601000 452520369 sales@maya-r.com China 11693 57
Qingdao Free Trade Zone United International Co.,Ltd. 0532-83893697 18561902820 sissili@unitedint.com China 352 58
Shanghai civi chemical technology co.,Ltd 86-21-34053660 sale@labgogo.com China 9853 52
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Adamas Reagent, Ltd. 59
Nanjing Chemlin Chemical Co., Ltd 64
jiliang chemicals 60
Maya High Purity Chemicals 57
Qingdao Free Trade Zone United International Co.,Ltd. 58
Shanghai civi chemical technology co.,Ltd 52

View Latest Price from 4-Methoxy-2,5-dimethyl-3(2H)-furanone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Methoxy-2,5-dimethyl-3(2H)-furanone pictures 2026-09-02 4-Methoxy-2,5-dimethyl-3(2H)-furanone
4077-47-8
 $1.10-35.00 1kg 99% Henan Fengda Chemical Co., Ltd
4-Methoxy-2,5-dimethyl-3(2H)-furanone pictures 2026-06-30 4-Methoxy-2,5-dimethyl-3(2H)-furanone
4077-47-8
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
4-Methoxy-2,5-dimethyl-3(2H)-furanone pictures 2026-03-20 4-Methoxy-2,5-dimethyl-3(2H)-furanone
4077-47-8
 $10.00 1kg 99% 100 mt Hebei Chuanghai Biotechnology Co., Ltd

4-Methoxy-2,5-dimethyl-3(2H)-furanone Spectrum

4-Methoxy-2,5-dimethyl-3(2H)-furanone(4077-47-8)1HNMR4-Methoxy-2,5-dimethyl-3(2H)-furanone(4077-47-8)FT-IR4-Methoxy-2,5-dimethyl-3(2H)-furanone(4077-47-8)IR

4077-47-8 (4-Methoxy-2,5-dimethyl-3(2H)-furanone) Related Search:

Dimethyl carbonate Dimethyl sulfate Dimethyl phthalate Dimethyl ether Dacthal
Acetone oxime Furazolidone Dimethyl fumarate N,N-Dimethylformamide Dimethyl sulfoxide
Ethane Dimethylglyoxime disodium salt 2,5-Dimethyl-3(2H)-furanone Fraision butyrate 4-Hydroxy-5-methyl-3-furanone
4,5-Dihydro-2-methylfuran 2,3-Dihydrofuran 2,5-Dimethyl-3(2H)furanone

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FRAISION METHYL ETHER 4-Methoxy-2,5-dimethyl-3(2H)-furfuran ketone Furfuran ketone methyl ether 4-METHOXY-2,5-DIMETHYL-3(2H)-FURANONE FEMA NO.3664 97+% 4-METHOXY-2,5-DIMETHYL-3(2H)-FURANONE 2,5-dimethyl-4-methoxy-2,3-dihydro-3-furanone 2,5-DIMETHYL-4-METHOXY-3(2H)-FURANONE 2,5-dimethyl 4-methoxy furan-3-one 3(2H)-Furanone, 2,5-dimethyl-4-methoxy 4-methoxy-2,5-dimethyl-3(2h)-furanon 4-methoxy-2,5-dimethylfuran-3(2H)-one dimethylmethoxyfuranone,2,5-dimethyl-4-methoxy-2,3-dihydro-3-furanone 2,5-Dimethyl-4-Methoxy-2,3-Dih 2,5-Dimethyl-4-methoxy-2,3-dihydro-furan-3-one Methoxyfuraneol 4-methoxy-2,5-dimethyl-3-furanone 4-methoxy-2,5-dimethyl-furan-3-one 4-methoxy-2,5-dimethylfuran-3-one 4-Methoxy-2,5-diMethyl-2,3-dihydrofuran-3-one 4-Methoxy-2,5-diMethyl-3(2H)-furanone Mesifurane 2,5-DIMETHYL-4-METHOXY-3(2H)-FURANONE, 9 2,5-Dimethyl-4-methoxy-3(2H)-furanone> 4-Methoxy-2,5-dimethyl-3(2H)-furanone USP/EP/BP strawberry furanone methyl ether TIANFU CHEM-- 4-Methoxy-2,5-dimethyl-3(2H)-furanone 13C,2H3]-2,5-Dimethyl-4-methoxy-3(2H)-furanone UNII:3241BIM975 2,5-Dimethyl-4-methoxy-3(2H)-furanone 3(2H)-Furanone, 4-methoxy-2,5-dimethyl- FEMA 3664 FURANEOL METHYL ETHER Mesifurane mesifuran 2,5-Dimethyl-4-methoxyfuran-3(2H)-one 4077-47-8 Alphabetical Listings C-D Flavors and Fragrances