1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
- CAS No.
- 67469-81-2
- Chemical Name:
- 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
- Synonyms
- CS-1078;GBR 12935 HCl;GBR-12935 2HCL;GBR-2935(dihydrochloride);GBR 12935 DIHYDROCHLORIDE;GBR 12935 (hydrochloride);GBR 12935 dihydrochloride, >=98%;1-(2-(BENZHYDRYLOXY)ETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE.2HCL;1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride;1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
- CBNumber:
- CB2351371
- Molecular Formula:
- C28H35ClN2O
- Molecular Weight:
- 451.05
- MDL Number:
- MFCD00083175
- MOL File:
- 67469-81-2.mol
- MSDS File:
- SDS
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| solubility | H2O: 20 mg/mL with warming |
| form | powder |
| color | white |
| Water Solubility | H2O: 20mg/mL (with warming) |
| InChI | InChI=1S/C28H34N2O.ClH/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27;/h1-9,11-12,14-17,28H,10,13,18-24H2;1H |
| InChIKey | YMGXBGVMAOTRFZ-UHFFFAOYSA-N |
| SMILES | C(C1C=CC=CC=1)(C1C=CC=CC=1)OCCN1CCN(CCCC2C=CC=CC=2)CC1.Cl |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G9659 | GBR 12935 dihydrochloride ≥98% (TLC), powder | 67469-81-2 | 25mg | $195 | 2023-01-07 | Buy |
| Sigma-Aldrich | G9659 | GBR 12935 dihydrochloride ≥98% (TLC), powder | 67469-81-2 | 100mg | $629 | 2022-05-15 | Buy |
| Cayman Chemical | 17700 | GBR 12935 (hydrochloride) ≥98% | 67469-81-2 | 10mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 17700 | GBR 12935 (hydrochloride) ≥98% | 67469-81-2 | 25mg | $135 | 2024-03-01 | Buy |
| Cayman Chemical | 17700 | GBR 12935 (hydrochloride) ≥98% | 67469-81-2 | 50mg | $253 | 2024-03-01 | Buy |
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Chemical Properties,Uses,Production
Uses
A very potent and selective inhibitor of dopamine uptake
Definition
ChEBI: A hydrochloride salt that is obtained by reaction of 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine with two equivalents of hydrogen chloride. Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal memb anes).
Biochem/physiol Actions
GBR 12935 inhibits the dopamine and norepinephrine transporters with Kis of 21.5 nM and 225 nM, respectively. It does not inhibit the serotonin transporter (Ki = 6.5 mM). GBR 12935 binds to a nondopaminergic piperazine site in blood platelets and brain that has been identified as cytochrome P450.
in vivo
GBR 12935 dihydrochloride (1-32 mg/kg; repeat injection; 7 d) elevates locomotion activity to a greater extent in C57BL/6J mice than DBA/2J mice, and (10 mg/kg; injection; 7 d) results few mice sensitized to cocaine-induced stereotypy with repeated injections[3].
| Animal Model: | Adult male DBA/2J and C57BL/6J mice (22-30 g)[3] |
| Dosage: | 1.0, 3.2, 10, 32 mg/kg |
| Administration: | Repeat injection; for 7 days |
| Result: | Elevated locomotion activity to a greater extent in C57BL/6J mice than DBA/2J mice. No stereotypy was induced by an eighth day challenge of 10 mg/kg GBR 12935 dihydrochloride in mice pretreated with seven dally injections of either 32 mg/kg cocaine or saline. |
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32431 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Hebei Miaoyin Technology Co.,Ltd | +852-852-95427495 +85295427495 | kathy@hbyinsheng.com | China | 3512 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43339 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
View Lastest Price from 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-18 | GBR 12935 dihydrochloride
67469-81-2
|
US $50.00-108.00 / mg | 99.09% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-09-04 | 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
67469-81-2
|
US $1.00 / KG | 1KG | 98% | 20kg | Career Henan Chemical Co |
-
- GBR 12935 dihydrochloride
67469-81-2
- US $50.00-108.00 / mg
- 99.09%
- TargetMol Chemicals Inc.
-
- 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
67469-81-2
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
