Nipecotic acid
- CAS No.
- 498-95-3
- Chemical Name:
- Nipecotic acid
- Synonyms
- PIPERIDINE-3-CARBOXYLIC ACID;3-PIPERIDINECARBOXYLIC ACID;H-NIP-OH;DL-Nip-OH;H-D-NIPC-OH;H-DL-Nip-OH;H-DL-NIPC-OH;nipecoticaci;H-DL-PIC(3)-OH;NIPECOTIC ACID
- CBNumber:
- CB2357287
- Molecular Formula:
- C6H11NO2
- Molecular Weight:
- 129.16
- MDL Number:
- MFCD00005992
- MOL File:
- 498-95-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Nipecotic acid 98% | 211672 | 1g | $35.5 |
| Nipecotic acid 98% | 211672 | 5g | $38.9 |
| 3-Piperidinecarboxylic Acid >98.0%(T) | N0420 | 25g | $63 |
| 3-Piperidinecarboxylic Acid >98.0%(T) | N0420 | 500g | $561 |
| Nipecotic acid 98% | 211672 | 25g | $94.6 |
| More product size | |||
| Melting point | 261 °C (dec.) (lit.) |
|---|---|
| Boiling point | 239.22°C (rough estimate) |
| Density | 1.1426 (rough estimate) |
| refractive index | 1.4587 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | water: soluble50mg/mL, clear, colorless to faintly yellow |
| pka | pK1:3.35(+1);pK2:10.64(0) (25°C) |
| form | Solid |
| color | White |
| Water Solubility | Soluble in water |
| Merck | 14,6560 |
| BRN | 81096 |
| InChI | InChI=1S/C6H11NO2/c8-6(9)5-2-1-3-7-4-5/h5,7H,1-4H2,(H,8,9) |
| InChIKey | XJLSEXAGTJCILF-UHFFFAOYSA-N |
| SMILES | N1CCCC(C(O)=O)C1 |
| CAS DataBase Reference | 498-95-3(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 1U1QTN40SY |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TM6125380 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Nipecotic acid price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 211672 | Nipecotic acid 98% | 498-95-3 | 1g | $35.5 | 2023-01-07 | Buy |
| Sigma-Aldrich | 211672 | Nipecotic acid 98% | 498-95-3 | 5g | $38.9 | 2023-01-07 | Buy |
| TCI Chemical | N0420 | 3-Piperidinecarboxylic Acid >98.0%(T) | 498-95-3 | 25g | $63 | 2026-03-19 | Buy |
| TCI Chemical | N0420 | 3-Piperidinecarboxylic Acid >98.0%(T) | 498-95-3 | 500g | $561 | 2026-03-19 | Buy |
| Sigma-Aldrich | 211672 | Nipecotic acid 98% | 498-95-3 | 25g | $94.6 | 2023-01-07 | Buy |
Nipecotic acid Chemical Properties,Uses,Production
Chemical Properties
off-white to pale yellow-beige powder
Uses
(+/-)-Nipecotic Acid (cas# 498-95-3) is a compound useful in organic synthesis.
Definition
ChEBI: A piperidinemonocarboxylic acid that is piperidine in which one of the hydrogens at position 3 is substituted by a carboxylic acid group.
Synthesis Reference(s)
The Journal of Organic Chemistry, 28, p. 602, 1963 DOI: 10.1021/jo01037a531
General Description
R()-Nipecotic acid is a potential inhibitor of uptake of γ-aminobutyric acid (GABA) in rat brain slices. Lipophilic derivatives of nipecotic acid are used as drugs for the treatment of epilepsy.
Synthesis
93-60-7
498-95-3
The general procedure for the synthesis of 3-piperidinecarboxylic acid from methyl nicotinate was as follows: 0.25 g of methyl nicotinate with HRO/Na-β catalyst (50 mg) in 40 mL of deionized water was added to the reactor. Subsequently, the reactor was subjected to hydrogen pressure of 15 bar and heated at 120 °C for 1 h of reaction. Upon completion of the reaction, the catalyst was separated by centrifugation and the resulting mixture of clarified products was analyzed using GC-MS. The reaction achieved 100% conversion of methyl nicotinate and gave 3-piperidinecarboxylic acid in 100% yield.
References
[1] Patent: WO2017/60922, 2017, A1. Location in patent: Page/Page column 15; 22
Nipecotic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Bojing Chemical Co.,Ltd. | +86-86-02137122233 +8613795318958 | bj1@bj-chem.com | China | 299 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21592 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
View Lastest Price from Nipecotic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | Nipecotic acid
498-95-3
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-11-18 | Nipecotic acid
498-95-3
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2024-04-24 | Nipecotic acid
498-95-3
|
US $50.00 / kg | 1kg | 99.10% | 50000kg | Ouhuang Engineering Materials (Hubei) Co., Ltd |
-
- Nipecotic acid
498-95-3
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Nipecotic acid
498-95-3
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- Nipecotic acid
498-95-3
- US $50.00 / kg
- 99.10%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
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