3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE
- CAS No.
- 80288-49-9
- Chemical Name:
- 3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE
- Synonyms
- Furafilina;FURAFYLLINE;Furafyllinum;Furatheophylline;Furafylline, PDE inhibitor;Furafylline, 10 mM in DMSO;FURAFYLLINE INHIBITOR OF CYTOCHRO;Cytochrome P450,inhibit,Inhibitor,CYPs,Furafylline;3-(Furan-2-ylmethyl)-1,8-dimethyl-1H-purine-2,6(3H,7H)-dione;3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE
- CBNumber:
- CB2360403
- Molecular Formula:
- C12H12N4O3
- Molecular Weight:
- 260.25
- MDL Number:
- MFCD00153799
- MOL File:
- 80288-49-9.mol
- MSDS File:
- SDS
| Melting point | >162°C (dec.) |
|---|---|
| Boiling point | 543.6±60.0 °C(Predicted) |
| Density | 1.443±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | ethanol: 0.33 mg/mL |
| form | solid |
| pka | 8.62±0.70(Predicted) |
| color | white |
| InChIKey | KGQZGCIVHYLPBH-UHFFFAOYSA-N |
| FDA UNII | C2087G0XX3 |
| UNSPSC Code | 41106305 |
| NACRES | NA.77 |
3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | F124 | Furafylline ≥98% (HPLC) | 80288-49-9 | 5mg | $414 | 2024-03-01 | Buy |
| Cayman Chemical | 9000058 | Furafylline ≥95% | 80288-49-9 | 500μg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 9000058 | Furafylline ≥95% | 80288-49-9 | 1mg | $129 | 2024-03-01 | Buy |
| Cayman Chemical | 9000058 | Furafylline ≥95% | 80288-49-9 | 5mg | $317 | 2024-03-01 | Buy |
| ChemScene | CS-0027630 | Furafylline 99.86% | 80288-49-9 | 1mg | $180 | 2021-12-16 | Buy |
3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE Chemical Properties,Uses,Production
Uses
Furafylline is a selective inhibitor of human cytochrome P450. It is also reported to inhibit the oxidation of caffeine.
Definition
ChEBI: Furafylline is an oxopurine.
Biochem/physiol Actions
Furafylline (1,8-dimethyl-3-(2′ -furfuryl)methylxanthine) is a xanthine derivative. It is preferred in treating asthma. It serves as a N3-demethylation inhibitor of caffeine. Furafylline does not show much effect on human monooxygenase activities. It is considered as an efficient bronchodilator and as an inhibitor of anaphylactic reactions, when compared to theophylline.
in vivo
Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 μM in kinase experiment. Furafylline is a methylxanthine derivative that is introduced as a long-acting replacement for theophylline in the treatment of asthma. Administration of Furafylline is associated with an elevation in plasma levels of caffeine, due to inhibition of caffeine oxidation, a reaction catalysed by one or more hydrocarbon-inducible isoenzymes of P450. Furafylline has either very little or no effect on human monooxygenase activities catalysed by other isoenzymes of P450, including P4501ID1, P4501IC, P450IIIA[1].
3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29807 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 12272 | 58 |
| Young Lively PharminBlock Co.,Ltd | +undefined18600731423 | jason_gao@yl-pharminblock.com | China | 1944 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
View Lastest Price from 3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-29 | Furafylline
80288-49-9
|
US $122.00-367.00 / mg | 99.61% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-12-31 | 3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE
80288-49-9
|
US $1.00 / KG | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
-
- Furafylline
80288-49-9
- US $122.00-367.00 / mg
- 99.61%
- TargetMol Chemicals Inc.
-
- 3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE
80288-49-9
- US $1.00 / KG
- 95-99%
- Career Henan Chemical Co