2,2-DIMETHYL-3-PHENYLPROPANOIC ACID
- CAS No.
- 5669-14-7
- Chemical Name:
- 2,2-DIMETHYL-3-PHENYLPROPANOIC ACID
- Synonyms
- Benzyldimethylacetic acid;α,α-Dimethylhydrocinnamic acid;2-Benzyl-2-methylpropanoic acid;2,2-DIMETHYL-3-PHENYLPROPANOIC ACID;a, a-DiMethyl-benzenepropanoic acid;Benzenepropanoic acid, α,α-dimethyl-;2,2-dimethyl-3-phenyl-propionic acid;alpha,alpha-Dimethylhydrocinnamic acid;alpha,alpha-Dimethylbenzenepropanoic acid;HYDROCINNAMIC ACID, alpha,alpha-DIMETHYL-
- CBNumber:
- CB2397537
- Molecular Formula:
- C11H14O2
- Molecular Weight:
- 178.23
- MDL Number:
- MFCD01722147
- MOL File:
- 5669-14-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2,2-Dimethyl-3-phenylpropanoic acid | FD136559 | 50mg | $150 |
| 2,2-Dimethyl-3-phenylpropanoic acid | FD136559 | 25mg | $150 |
| 2,2-Dimethyl-3-phenylpropanoic acid | FD136559 | 100mg | $150 |
| 2,2-Dimethyl-3-phenylpropanoic acid 97% | AS41250 | 1g | $222 |
| 2,2-Dimethyl-3-phenylpropanoic acid 97% | AS41250 | 5g | $784 |
| Melting point | 59-60 °C(Solv: ligroine (8032-32-4)) |
|---|---|
| Boiling point | 200 °C(Press: 1.5 Torr) |
| Density | 1.070±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 4.73±0.11(Predicted) |
| Appearance | White to off-white Solid |
| EWG's Food Scores | 1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H302-H335-H319 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
2,2-DIMETHYL-3-PHENYLPROPANOIC ACID price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FD136559 | 2,2-Dimethyl-3-phenylpropanoic acid | 5669-14-7 | 50mg | $150 | 2026-06-04 | Buy |
| Biosynth | FD136559 | 2,2-Dimethyl-3-phenylpropanoic acid | 5669-14-7 | 25mg | $150 | 2026-06-04 | Buy |
| Biosynth | FD136559 | 2,2-Dimethyl-3-phenylpropanoic acid | 5669-14-7 | 100mg | $150 | 2026-06-04 | Buy |
| Activate Scientific | AS41250 | 2,2-Dimethyl-3-phenylpropanoic acid 97% | 5669-14-7 | 1g | $222 | 2026-06-04 | Buy |
| Activate Scientific | AS41250 | 2,2-Dimethyl-3-phenylpropanoic acid 97% | 5669-14-7 | 5g | $784 | 2026-06-04 | Buy |
2,2-DIMETHYL-3-PHENYLPROPANOIC ACID Chemical Properties,Uses,Production
Synthesis
103-28-6
5669-14-7
The general procedure for the synthesis of 2,2-dimethyl-3-phenylpropionic acid from benzyl isobutyrate was as follows: hexamethyldisilazane (34 g, 0.21 mol) was dissolved in tetrahydrofuran (280 mL) at -78 °C, and a hexane solution of 1.67 M n-butyllithium (127 mL, 0.21 mol) was slowly added dropwise. The reaction solution was warmed to 0 °C within 1 h and subsequently cooled again to -78 °C. A solution of tetrahydrofuran (70 mL) of benzyl isobutyrate (25 g, 0.14 mol) was added dropwise and kept stirring at -78 °C for 1 hour. At the same temperature, chlorotrimethylsilane (36 mL, 0.12 mol) was continued to be added dropwise with stirring for 1 h. The reaction was warmed up to room temperature and stirred continuously for 19 h. The reaction was completed by adding a solution of benzyl isobutyrate (25 g, 0.14 mol) in tetrahydrofuran (70 mL). Upon completion of the reaction, some of the solvent was concentrated under reduced pressure and the resulting white suspension was diluted with hexane (200 mL) and the white solid was removed by filtration through diatomaceous earth under nitrogen protection. The filtrate was distilled under reduced pressure to yield a light yellow oil, which was converted to a brown oil by heating at 100 °C for 2 hours. The oily substance was mixed with 10 mL of 1 M hydrochloric acid, stirred at 60 °C for 4 h. After neutralization with saturated aqueous sodium bicarbonate solution, it was extracted with ethyl acetate (100 mL x 2) and chloroform (100 mL x 2), respectively. The organic layers were combined, concentrated and purified by medium-pressure silica gel column chromatography (80 g of silica gel, 100% ethyl acetate) to afford 8.41 g of the target product, 2,2-dimethyl-3-phenylpropionic acid, as white crystals.1H NMR (CDCl3, Me4Si, 300 MHz) δ 7.20-7.30 (m, 3H), 7.16 (d, J = 7.1 Hz, 2H). 2.89 (s, 2H), 1.21 (s, 6H).
References
[1] Tetrahedron Letters, 2002, vol. 43, # 33, p. 5837 - 5840
[2] Journal of Organic Chemistry, 1980, vol. 45, # 5, p. 891 - 894
[3] Patent: US2013/253204, 2013, A1. Location in patent: Paragraph 0217; 0218
[4] Patent: US9212348, 2015, B2. Location in patent: Page/Page column 173; 174
2,2-DIMETHYL-3-PHENYLPROPANOIC ACID Preparation Products And Raw materials
2,2-DIMETHYL-3-PHENYLPROPANOIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
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| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Nanjing Bicbiotechnology Co., Ltd | +86-2552131256 +86-18251840740 | sales@bicbiotech.com | China | 5994 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Xiannuo Biotechnology Co., Ltd. | 021-50718719 13918719472 | China | 979 | 58 | |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9340 | 55 |
| Shanghai Witofly Chemical Co.,Ltd | sales@witofly.com | China | 2864 | 52 |
