3-AMINO-ISONICOTINIC ACID METHYL ESTER
- CAS No.
- 55279-30-6
- Chemical Name:
- 3-AMINO-ISONICOTINIC ACID METHYL ESTER
- Synonyms
- Tpc-py003;AKOS 93360;METHYL 3-AMINOISONICOTINATE;Methyl 3-Aminoisonicotina...;Methyl3-Aminoisonicotinate>METHYL 3-AMINOPYRIDINE-4-CARBOXYLATE;3-Amino-Isonitinic Acid Methyl Ester;3-AMINO-ISONICOTINIC ACID METHYL ESTER;3-Amino-iosnicotinic acid methyl ester;Methyl3-aminopyridine-4-carboxylate,97%
- CBNumber:
- CB2406062
- Molecular Formula:
- C7H8N2O2
- Molecular Weight:
- 152.15
- MDL Number:
- MFCD02082535
- MOL File:
- 55279-30-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Methyl 3-aminopyridine-4-carboxylate AldrichCPR | ANV00027 | 1 g | $197 |
| Methyl 3-Aminoisonicotinate >98.0%(GC) | M2653 | 1g | $58 |
| 3-AminoisonicotinicAcidMethylEster | A604785 | 1g | $85 |
| 3-Amino-isonicotinicacidmethylester 98% | JK172895 | 5g | $298 |
| Methyl 3-Aminoisonicotinate | OR14139 | 100g | $537 |
| More product size | |||
| Melting point | 84-86 |
|---|---|
| Boiling point | 292.5±20.0 °C(Predicted) |
| Density | 1.238±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 4.05±0.18(Predicted) |
| form | powder to crystal |
| color | White to Yellow to Green |
| InChI | InChI=1S/C7H8N2O2/c1-11-7(10)5-2-3-9-4-6(5)8/h2-4H,8H2,1H3 |
| InChIKey | XLQIGLBALJNHKR-UHFFFAOYSA-N |
| SMILES | C1=NC=CC(C(OC)=O)=C1N |
| CAS DataBase Reference | 55279-30-6(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-36/38 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
3-AMINO-ISONICOTINIC ACID METHYL ESTER price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ANV00027 | Methyl 3-aminopyridine-4-carboxylate AldrichCPR | 1 g | $197 | 2026-03-19 | Buy | |
| TCI Chemical | M2653 | Methyl 3-Aminoisonicotinate >98.0%(GC) | 55279-30-6 | 1g | $58 | 2026-03-19 | Buy |
| TRC | A604785 | 3-AminoisonicotinicAcidMethylEster | 55279-30-6 | 1g | $85 | 2021-12-16 | Buy |
| Frontier Specialty Chemicals | JK172895 | 3-Amino-isonicotinicacidmethylester 98% | 55279-30-6 | 5g | $298 | 2021-12-16 | Buy |
| Apolloscientific | OR14139 | Methyl 3-Aminoisonicotinate | 55279-30-6 | 100g | $537 | 2021-12-16 | Buy |
3-AMINO-ISONICOTINIC ACID METHYL ESTER Chemical Properties,Uses,Production
Chemical Properties
Yellow powder
Uses
3-Aminoisonicotinic Acid Methyl Ester is a useful synthetic intermediate. It is used in the synthesis of morpholinophenylquinazolines and related derivatives as PI3 kinase p110α inhibitors. It is also used to synthesize aryl tetrahydropyridine inhibitors of farnesyltransferase as antitumor agents.
Synthesis
67-56-1
7579-20-6
55279-30-6
3-Aminoisonicotinic acid (3.55 g, 25.7 mmol) was added with concentrated sulfuric acid (2.5 ml) and methanol (50 ml), and the reaction was heated to reflux at 80°C for 3 days. After completion of the reaction, methanol was removed by evaporation and the residue was diluted with deionized water (75 ml) and heated to 80 °C. Solid sodium carbonate was added slowly until no gas was produced. The reaction mixture was cooled to room temperature and extracted with dichloromethane (2 x 100 ml). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to give methyl 3-aminoisonicotinate as a beige solid (2.36 g, 60% yield). The product was characterized by 1H NMR (500 MHz, DMSO-d6): δ 8.24 (1H, s), 7.74 (1H, d, J=5.3 Hz), 7.46 (1H, d, J=5.2 Hz), 6.67 (2H, brs), 3.83 (3H, s). The mass spectrum (ES+) showed the molecular ion peak m/z 153 ([M+H]+).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 7, p. 1359 - 1362
[2] Patent: WO2005/49613, 2005, A1. Location in patent: Page/Page column 38
[3] Patent: WO2008/74749, 2008, A1. Location in patent: Page/Page column 62-63
[4] Chemical Communications, 2016, vol. 52, # 59, p. 9283 - 9286
3-AMINO-ISONICOTINIC ACID METHYL ESTER Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
| Win-Win Chemical CO., Limited | 0086-577-64498589 | sales@win-winchemical.com | CHINA | 998 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10404 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
View Lastest Price from 3-AMINO-ISONICOTINIC ACID METHYL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 3-AMINO-ISONICOTINIC ACID METHYL ESTER
55279-30-6
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2019-07-06 | 3-AMINO-ISONICOTINIC ACID METHYL ESTER
55279-30-6
|
US $1.00 / kg | 1kg | 98% | 500KG | Career Henan Chemical Co |
-
- 3-AMINO-ISONICOTINIC ACID METHYL ESTER
55279-30-6
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 3-AMINO-ISONICOTINIC ACID METHYL ESTER
55279-30-6
- US $1.00 / kg
- 98%
- Career Henan Chemical Co
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