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D(-)-Arginine

D(-)-Arginine structure

CAS No.: 157-06-2

Chemical Name:: D(-)-Arginine

Synonyms: D-ARGININE;H-D-ARG-OH;D-ARG;D-Arg-OH;D-Arginin;H-D-Arginine;ARGININE, D-;D-(-)-ARGININE;R-(-)-ARGININE;D-Arginine，98%

CBNumber:: CB2408147

Molecular Formula:: C6H14N4O2

Molecular Weight:: 174.2

MDL Number:: MFCD00063116

MOL File:: 157-06-2.mol

MSDS File:: SDS

Last updated:2026-01-13 11:16:57

Product description	Number	Pack Size	Price
D-Arginine ≥98% (TLC)	A2646	1g	$114
D-Arginine ≥98% (TLC)	A2646	5g	$355.02
D-(-)-Arginine >98.0%(T)	A1029	1g	$57
D-(-)-Arginine >98.0%(T)	A1029	5g	$196
D-Arginine ≥98% (TLC)	A2646	250mg	$38.67
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D(-)-Arginine Properties

Melting point	226 °C (dec.) (lit.)
alpha	-28.5 º (c=8, 6 N HCl)
Boiling point	305.18°C (rough estimate)
Density	1.2297 (rough estimate)
refractive index	-23 ° (C=8, 6mol/L HCl)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Aqueous Acid (Slightly), Water (Slightly)
pka	2.49±0.24(Predicted)
form	Solid
color	White to Off-White
Water Solubility	SOLUBLE
Sensitive	Air Sensitive
BRN	1725412
Major Application	peptide synthesis
InChI	1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m1/s1
InChIKey	ODKSFYDXXFIFQN-SCSAIBSYSA-N
SMILES	N[C@H](CCCNC(N)=N)C(O)=O
LogP	-0.999 (est)
CAS DataBase Reference	157-06-2(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	R54Z304Z7C
EPA Substance Registry System	D-Arginine (157-06-2)
UNSPSC Code	12352209
NACRES	NA.32

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319

Precautionary statements

P264-P280i-P337+P313-P305+P351+P338

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xi,Xn

Risk Statements

36-36/37/38-20/21/22

Safety Statements

26-36

WGK Germany

RTECS

CF1934220

TSCA

TSCA listed

HazardClass

IRRITANT

HS Code

29252000

Storage Class

11 - Combustible Solids

NFPA 704

	1
2		0

D(-)-Arginine price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A2646	D-Arginine ≥98% (TLC)	157-06-2	1g	$114	2025-07-31	Buy
Sigma-Aldrich	A2646	D-Arginine ≥98% (TLC)	157-06-2	5g	$355.02	2025-07-31	Buy
TCI Chemical	A1029	D-(-)-Arginine >98.0%(T)	157-06-2	1g	$57	2025-07-31	Buy
TCI Chemical	A1029	D-(-)-Arginine >98.0%(T)	157-06-2	5g	$196	2025-07-31	Buy
Sigma-Aldrich	A2646	D-Arginine ≥98% (TLC)	157-06-2	250mg	$38.67	2025-07-31	Buy

Product number	Packaging	Price	Buy
A2646	1g	$114	Buy
A2646	5g	$355.02	Buy
A1029	1g	$57	Buy
A1029	5g	$196	Buy
A2646	250mg	$38.67	Buy

D(-)-Arginine Chemical Properties,Uses,Production

Description

D-arginine is the D-form of arginine, which is a kind of amino acids. It can be reacted with hydrogen peroxide for non-enzymatic synthesis of nitric oxide. It has certain pharmacological activities. For example, its derivative, 1-deamino-8-D-arginine vasopressin is useful for the management of haemophilia and von Willebrand’s disease. It also has the potential to inhibit the proliferation of certain cancer cells. In biological research, D-arginine is frequently used in the studies of L-arginine/nitric oxide pathway as an inactive form of L-arginine.

Chemical Properties

white to light yellow crystal powde

Uses

Arginine is an essential amino acid found in food and plant sources, and many biological systems.
D-Arginine is extensively used in studies on L-arginine/nitric oxide pathway as an inactive form of L-arginine, even in man.
D-Arginine is slightly soluble (in water) and a moderately acidic compound (based on its pKa). D-Arginine can be found in human epidermis and platelet tissues. Within the cell, D-arginine is primarily located in the peroxisome. D-Arginine specifically can inhibit arginine decarboxylase enzymes and also functions as a metabolite.

Uses

1-Deamino-8-D-arginine vasopressin makes a new pharmacological approach to the management of haemophilia and von Willebrand's disease. A novel nonenzymatic pathway for the generation of nitric oxide is by the reaction of hydrogen peroxide and d- or l-arginine.

Definition

ChEBI: D-arginine is a D-alpha-amino acid that is the D-isomer of arginine. It has a role as an EC 4.1.1.19 (arginine decarboxylase) inhibitor and a mouse metabolite. It is a D-alpha-amino acid and an arginine. It is a conjugate base of a D-argininium(1+). It is a conjugate acid of a D-argininate. It is an enantiomer of a L-arginine.

in vivo

D-arginine (1 mg/kg, i.v., caudal veins, every two days) sensitize osteosarcoma to radiotherapy in a mouse model of subcutaneous osteosarcoma^[3].
The number of D-arginine residues in cell-penetrating peptides (i.v.) significantly affects their cellular uptake behavior and systemic toxicity in mice^[4].
D-Arginine (700 mg/kg, i.p.) displays central stimulant properties and increases spontaneous motor activity in mice^[5].
D-arginine (i.p.) shows a light toxicity order (LD50: 2800 mg/kg) in mice^[5].
D-arginine (1400 mg/kg, i.p.) protects against Pentylenetetrazole-induced convulsions in mice^[5].
D-arginine (1000 mg/kg, p.o., 16 weeks) significantly alters various enzymes and metabolites in the arginine metabolic pathways in male SD rats^[6].
D-arginine (1000 mg/kg, s.c., coadministered with L-arginine) blocks antinociception elicited by L-arginine (HY-N0455) in mice with Carrageenin-induced hyperalgesia^[7].
D-arginine (20 mg/kg, s.c.) does not significantly alter the percentage of antinociception in mice^[8].

Animal Model:	Female BALB/c mice (anesthetized by intraperitoneal injection of 3% pentobarbital sodium; K7M2 cells were injected subcutaneously; X-ray irradiation)^[2]
Dosage:	1 mg/kg
Administration:	Intravenous injection (i.v.), caudal veins, every two days
Result:	Inhibited tumor volume (20 days).

IC 50

Human Endogenous Metabolite

References

https://www.alfa.com/zh-cn/catalog/A16137/
Iannucci, N. B., et al. "Antiproliferative effect of 1-deamino-8-D-arginine vasopressin analogs on human breast cancer cells." Future Medicinal Chemistry 3.16(2011):1987-1993.
Ripoll, Giselle, et al. "Angiostatic activity of 1-Deamino-8-D-Arginine vasopressin and novel peptide analogues in breast cancer cells." Cancer Research 68(2008).
Navarro, Eduardo, et al. "Toxicological and Pharmacological Effects of D-Arginine." Basic & Clinical Pharmacology & Toxicology97.3(2005):149-154.

D(-)-Arginine synthesis

Synthesis of D(-)-Arginine from DL-Arginine

D(-)-Arginine Preparation Products And Raw materials

Raw materials

O-methylisourea D-Ornithine monohydrochloride

Preparation Products

D(-)-Arginine Suppliers

Global( 562)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8753	58
Wuhan Fortuna Chemical Co., Ltd	+86-027-59207850 +86-13986145403;	info@fortunachem.com	China	6010	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	+86-15350851019; +8615350851019	admin@86-ss.com	China	999	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Taizhou Tianhong Biochemistry Technology Co., Ltd.	0523-86132544	sales@thbiochem.com	CHINA	305	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21599	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29833	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2161	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Wuhan Fortuna Chemical Co., Ltd	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	58
Capot Chemical Co.,Ltd.	60
Taizhou Tianhong Biochemistry Technology Co., Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58

View Lastest Price from D(-)-Arginine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-01-27	D(-)-Arginine 157-06-2	US $0.00-0.00 / kg	1kg	98%min	500kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-01-21	D(-)-Arginine 157-06-2	US $999.00-800.00 / kg	1kg	99%	5000	HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
2026-01-21	D(-)-Arginine 157-06-2	US $100.00-75.00 / kg	1kg	99%	5000	HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

D(-)-Arginine
157-06-2
US $0.00-0.00 / kg
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

D(-)-Arginine
157-06-2
US $999.00-800.00 / kg
99%
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

D(-)-Arginine
157-06-2
US $100.00-75.00 / kg
99%
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

D(-)-Arginine Spectrum

D(-)-Arginine(157-06-2)¹HNMR D(-)-Arginine(157-06-2)¹³CNMR D(-)-Arginine(157-06-2)IR1 D(-)-Arginine(157-06-2)IR2 D(-)-Arginine(157-06-2)Raman

157-06-2(D(-)-Arginine)Related Search:

L(+)-Arginine EPA Guanidineacetic acid Glycine 3-Guanidinopropionic acid

ARGINASE 6-Aminocaproic acid ALTRENOGEST 5-Amino-2-methylpyridine D-Lysine

H-D-CIT-OH D-Ornithine monohydrochloride D-Ribose Arginine arginine aspirin

BOC-D-Arg(Tos)-OH D-(-)-Arginine hydrochloride N-Fmoc-N'-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-D-arginine

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(2R)-2-ammonio-5-(diaminomethylideneammonio)pentanoate R-(-)-ARGININE (R)-2-AMINO-5-GUANIDINOPENTANOIC ACID RARECHEM AB PP 1748 D-ARG D-(-)-ARGININE D-ARGININE D-2-AMINO-5-GUANIDINOVALERIC ACID H-D-Arginine (-)-D-arginine hydrate D-ARGININE FREE BASE d-2-amino-5-guanidinopentanoic acid (2R)-2-amino-5-(diaminomethylideneamino)pentanoic acid ARGININE, D-(RG) ARGININE, D- H-D-ARG-OH D-ARG.FREE BASE D-ARGININE BASE (2R)-2-Amino-5-(diaminomethylideneamino)pentanoic acid hydrate D-Arginine ,99% D-Arginine,(R)-2-Amino-5-guanidinopentanoic acid D-GuanidineaMinovaleric acid D-α-AMino-δ-guanidovaleric acid D-Arg-OH H-D-Arg-OH (R)-2-Amino-5-guanidinopentanoic acid D-2-Amino-5-guanidinovaleric acid D-Arginine,99%e.e. (2R)-2-amino-5-carbamimidamidopentanoic acid D-Arginin Arginine Impurity 5（D-Arginine） D-(-)-Arginine > D-Arginine, 99%, reagent grade D-Arginine，98% D(-)-Arginine USP/EP/BP D- arginine base USP/EP/BP dextro-arginine TIANFU-CHEM D(-)-Arginine D-Arginine (free base) extrapure CHR, 99% (2R)-2-amino-5-guanidino-pentanoic acid D-Arginine 157-06-2 C6H14N4O2 for Resolution of Acids Optical Resolution Amino Acid Derivatives Specialty Synthesis Peptide Synthesis amino Amino Acids Arginine [Arg, R] Amino Acids and Derivatives alpha-Amino Acids Amino Acids Biochemistry for Resolution of Acids Optical Resolution Synthetic Organic Chemistry PROTECTED AMINO ACID & PEPTIDES Amino Acids Derivatives