ChemicalBook >> CAS DataBase List >>4-Hydroxybenzyl cyanide

4-Hydroxybenzyl cyanide

4-Hydroxybenzyl cyanide structure

CAS No.: 14191-95-8

Chemical Name:: 4-Hydroxybenzyl cyanide

Synonyms: 2-(4-HYDROXYPHENYL)ACETONITRILE;4-HYDROXYPHENYLACETONITRILE;4-Hydroxybenzyl;4-cyanomethylphenol;4-Hydroxybenzyl cyan;4-Hydroxybenzylnitrile;4-HYDROXY BENZYLCYARIDE;4-HYDROXYBENZYL CYANIDE;P-HYDROXYBENZYL CYANIDE;p-Hydroxybenzacetonitrile

CBNumber:: CB2411323

Molecular Formula:: C8H7NO

Molecular Weight:: 133.15

MDL Number:: MFCD00002383

MOL File:: 14191-95-8.mol

MSDS File:: SDS

Last updated:2025-08-22 22:33:46

Request For Quotation

4-Hydroxybenzyl cyanide Properties

Melting point	67-70 °C (lit.)
Boiling point	330 °C/756 mmHg (lit.)
Density	1.1475 (rough estimate)
refractive index	1.5260 (estimate)
Flash point	178 °C
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform, DMSO, Methanol (Slightly)
pka	9.63±0.13(Predicted)
form	Solid
color	Light Brown to Beige
Water Solubility	slightly soluble
BRN	1934470
Exposure limits	NIOSH: IDLH 25 mg/m3
InChIKey	AYKYOOPFBCOXSL-UHFFFAOYSA-N
LogP	0.591 (est)
CAS DataBase Reference	14191-95-8(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	18Q5J224RM
NIST Chemistry Reference	4-Hydroxyphenylacetic acid nitrile(14191-95-8)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

Hazard Codes

Risk Statements

Safety Statements

RIDADR

3439

WGK Germany

RTECS

AM0530000

Hazard Note

Irritant

HazardClass

6.1

PackingGroup

III

HS Code

29269095

NFPA 704

	1
2		0

4-Hydroxybenzyl cyanide price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H21101	4-Hydroxyphenylacetonitrile 98%	14191-95-8	5g	$25.46	2025-07-31	Buy
Sigma-Aldrich	H21101	4-Hydroxyphenylacetonitrile 98%	14191-95-8	25g	$38.28	2025-07-31	Buy
TCI Chemical	H0657	4-Hydroxybenzyl Cyanide >99.0%(GC)	14191-95-8	25g	$75	2025-07-31	Buy
TCI Chemical	H0657	4-Hydroxybenzyl Cyanide >99.0%(GC)	14191-95-8	500g	$453	2023-01-07	Buy
TCI Chemical	H0657	4-Hydroxybenzyl Cyanide >99.0%(GC)	14191-95-8	5g	$30	2025-07-31	Buy

Product number	Packaging	Price	Buy
H21101	5g	$25.46	Buy
H21101	25g	$38.28	Buy
H0657	25g	$75	Buy
H0657	500g	$453	Buy
H0657	5g	$30	Buy

4-Hydroxybenzyl cyanide Chemical Properties,Uses,Production

Chemical Properties

Light Brown Solid

Uses

4-Hydroxyphenylacetonitrile (cas# 14191-95-8) is a compound useful in organic synthesis.

Definition

ChEBI: A hydroxynitrile that is phenylacetonitrile substituted by a hydroxy group at position 4.

Synthesis

104-47-2

14191-95-8

General procedure for the synthesis of 2-(4-hydroxyphenyl)acetonitrile from 2-(4-methoxyphenyl)acetonitrile: 2-(4-methoxyphenyl)acetonitrile (500 g, 3.397 mol) was slowly added to a stirred suspension of aluminum chloride (1358.86 g, 10.19 mol) in toluene (2100 ml) over a period of 20-30 min at room temperature. The reaction mixture was gradually warmed up to 70°C and maintained at this temperature for 4-6 hours. The reaction progress was monitored by TLC (unfolding agent: 5% ethyl acetate/hexane). Upon completion of the reaction, the mixture was slowly poured into pre-cooled aqueous hydrochloric acid solution (3000 ml of water; 667 ml of concentrated hydrochloric acid), keeping the temperature below 20°C. The organic layer was separated and the aqueous layer was extracted with ethyl acetate (3 x 500 ml). The organic layers were combined, washed with water (2 x 500 ml) and dried over anhydrous sodium sulfate (50 g). The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was stirred with a mixture of hexane (800 ml) and ethyl acetate (40 ml) for 1 h. The solid product was collected by filtration and washed with hexane (300 ml). The resulting light brown product was dried under vacuum at 35-40°C. Yield: 431.6 g (95.41% yield); HPLC purity: 99.56%; Melting point: 70-71.6 °C (DMSO-d6).1H NMR (DMSO-d6, δ ppm): 9.55 (s, 1H, ArOH), 7.15 (d, 2H, ArH), 6.80 (d, 2H, ArH), 3.84 (s, 2H , CH2).13C NMR (DMSO-d6, δ ppm): 156.99, 129.40, 121.21, 119.80, 115.85, 21.73. IR (KBr, cm-1): 3340.71, 2268.29, 1614.42, 1516.05, 1446.61, 1408.04, 1263.37, 1222.37, 1222.04. 1263.37, 1222.87, 1105.21, 943.19, 819.75, 759.95, 707.88, 578.64. GC-MS (m/z): 133 (base peak), 106, 90, 78.

References

[1] Patent: WO2009/84037, 2009, A2. Location in patent: Page/Page column 7; 8; 18-19
[2] European Journal of Organic Chemistry, 2007, # 21, p. 3449 - 3462
[3] Letters in Organic Chemistry, 2011, vol. 8, # 1, p. 48 - 52
[4] Journal of Chemical Research, 2004, # 10, p. 693 - 694
[5] Journal fuer Praktische Chemie (Leipzig), 1987, vol. 329, # 6, p. 963 - 974

4-Hydroxybenzyl cyanide synthesis

Synthesis of 4-Hydroxybenzyl cyanide from 4-Hydroxybenzyl alcohol and Ethyl formate

4-Hydroxybenzyl cyanide Preparation Products And Raw materials

Raw materials

N-(4-HYDROXYPHENYL)GLYCINE 4-Methoxybenzyl cyanide Methyl formate 4-Hydroxybenzyl alcohol Hydrochloric acid

Aluminum chloride

1of2

Preparation Products

4-Hydroxyphenylacetamide 4-HYDROXY-3-NITROPHENYLACETIC ACID 4-(Cyanomethyl)benzeneboronic acid pinacol ester tert-Butyl 2-[4-(cyanoMethyl)phenoxy]acetate α-(4’-Hydroxyphenyl)phloroacetophenone

4-(2-OxiranylMethoxy)benzeneacetonitrile

1of2

4-Hydroxybenzyl cyanide Suppliers

Global( 486)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8617732866630	abby@chuanghaibio.com	China	8773	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5251	58
Hebei Junhua Import and Export Co., LTD	+86-18503288844	junhua1@hb-junhua.com	China	957	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29733	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21622	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49732	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Junhua Import and Export Co., LTD	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Xiamen AmoyChem Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from 4-Hydroxybenzyl cyanide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-05	4-Hydroxybenzyl cyanide 14191-95-8	US $0.00 / kg	1kg	98%	1000	Hebei Junhua Import and Export Co., LTD
2025-08-22	4-Hydroxybenzyl cyanide 14191-95-8	US $29.00 / g		97.01%	10g	TargetMol Chemicals Inc.
2025-08-22	4-Hydroxybenzyl cyanide 14191-95-8	US $29.00 / g		97.01%	10g	TargetMol Chemicals Inc.

4-Hydroxybenzyl cyanide
14191-95-8
US $0.00 / kg
98%
Hebei Junhua Import and Export Co., LTD

4-Hydroxybenzyl cyanide
14191-95-8
US $29.00 / g
97.01%
TargetMol Chemicals Inc.

4-Hydroxybenzyl cyanide
14191-95-8
US $29.00 / g
97.01%
TargetMol Chemicals Inc.

4-Hydroxybenzyl cyanide Spectrum

4-Hydroxybenzyl cyanide(14191-95-8)MS 4-Hydroxybenzyl cyanide(14191-95-8)¹HNMR 4-Hydroxybenzyl cyanide(14191-95-8)¹³CNMR 4-Hydroxybenzyl cyanide(14191-95-8)IR1 4-Hydroxybenzyl cyanide(14191-95-8)IR2 4-Hydroxybenzyl cyanide(14191-95-8)Raman

14191-95-8(4-Hydroxybenzyl cyanide)Related Search:

4-Hydroxy-D-(-)-2-phenylglycine 4-Hydroxybenzoic acid 4'-Hydroxyacetophenone 4-Methoxybenzyl cyanide 4-Hydroxybenzaldehyde

Tyramine Diphenylacetonitrile 4-Hydroxyphenylacetic acid Methylparaben p-(2-Methoxyethyl) phenol

4-Methoxyphenol Copper(I) Cyanide 2-(4-HYDROXYPHENYL)ACETALDEHYDE 3-(4-Hydroxyphenyl)propionic acid 4-Hydroxybenzyl alcohol

4-Hydroxyphenethyl alcohol 4-Hydroxyphenylacetamide Benzeneacetonitrile

1of4

(p-hydroxyphenyl)-acetonitril 4-hydroxy-benzeneacetonitril 4-hydroxybenzeneacetonitrile 4-cyanomethylphenol Acetonitrile, (p-hydroxyphenyl)- Benzeneacetonitrile, 4-hydroxy- p-Hydroxyphenylacetonitrile p-Hydroxybenzacetonitrile 4-HydroxybenzylCyanide98+% 4-HYDROXYPHENYLACETONITRILE 99+% 55) PARA HYDROXY BENZYL CYANIDE 4-Hydroxybenzyl 4-HYDROXY BENZYLCYARIDE PARA-HYDROXYPHENYLACETONITRILE 4-Hydroxybenzyl cyan 2-(4-Hydroxyphenyl)acetonitrile , 97+% 4-(Cyanomethyl)phenol, 4-Hydroxybenzyl cyanide 4-Hydroxyphenylacetonitrile, 97+% The hydroxy benzene acetonitrile 4-Hydroxyphenylacetonitrile 98% 4-HYDROXYBENZYL CYANIDE 4-HYDROXYPHENYLACETONITRILE 2-(4-HYDROXYPHENYL)ACETONITRILE P-HYDROXYBENZYL CYANIDE 4-HydroxybenzylCyanide> Para Hydroxy Phenyl Acetonitrile (PHPAcn) 4-Hydroxybenzylnitrile 4-Hydroxyphenyl acetonitrile (4-Hydroxybenzylcyanide) > 98% puriss for synthesis 4-Hydroxybenzyl cyanide, 10 mM in DMSO 4-Hydroxyphenylacetonitrile, 95% 14191-95-8 14191-91-8 14191-98-8 HOC6H4CH2CN Nitrogen Compounds Organic Building Blocks Cyanides/Nitriles C8 to C9 Building Blocks Aromatics Inhibitors Aromatic Nitriles john's OLED